Laura Marsh
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View article: 0892 Prodromal Parkinsonism in post-9/11 Veterans with Probable REM Sleep Behavior Disorder: A Pilot Study
0892 Prodromal Parkinsonism in post-9/11 Veterans with Probable REM Sleep Behavior Disorder: A Pilot Study Open
Introduction Rapid eye movement (REM) sleep behavior disorder (RBD) is the single strongest predictor of Parkinson’s disease (PD) risk. Given neurotrauma and psychiatric morbidity, the aging post-9/11 Veteran cohort is a target population …
View article: Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool
Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool Open
Importance: Test accuracy studies often use small datasets to simultaneously select an optimal cutoff score that maximizes test accuracy and generate accuracy estimates. Objective: To evaluate the degree to which using data-driven methods …
View article: Prefrontally mediated inhibition of memory systems in dissociative amnesia
Prefrontally mediated inhibition of memory systems in dissociative amnesia Open
Background The mechanisms underlying generalized forms of dissociative (‘psychogenic’) amnesia are poorly understood. One theory suggests that memory retrieval is inhibited via prefrontal control. Findings from cognitive neuroscience offer…
View article: Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool
Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool Open
Importance Test accuracy studies often use small datasets to simultaneously select an optimal cutoff score that maximizes test accuracy and generate accuracy estimates. Objective To evaluate the degree to which using data-driven methods to…
View article: Probability of major depression diagnostic classification using semi-structured versus fully structured diagnostic interviews
Probability of major depression diagnostic classification using semi-structured versus fully structured diagnostic interviews Open
Background: Different diagnostic interviews are used as reference standards for major depression classification in research. Semi-structured interviews involve clinical judgement, whereas fully structured interviews are completely scripted…
View article: The Accuracy of the Patient Health Questionnaire-9 Algorithm for Screening to Detect Major Depression: An Individual Participant Data Meta-Analysis
The Accuracy of the Patient Health Questionnaire-9 Algorithm for Screening to Detect Major Depression: An Individual Participant Data Meta-Analysis Open
Background: Screening for major depression with the Patient Health Questionnaire-9 (PHQ-9) can be done using a cutoff or the PHQ-9 diagnostic algorithm. Many primary studies publish results for only one approach, and previous meta-analyses…
View article: 1720 Frailty and the impact of Electronic Advance Care Planning records on readmission rates and location of end of life care
1720 Frailty and the impact of Electronic Advance Care Planning records on readmission rates and location of end of life care Open
Introduction Older people with severe frailty are 5 times more likely to die in the next 12 months than older non-frail people however prognosis and disease trajectory in frailty remains difficult to predict. Advance care planning (ACP) is…
View article: Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19
Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19 Open
Background While inflammatory and immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in peripheral blood are extensively described, responses at the upper respiratory mucosal site of initial infectio…
View article: Assessing the Severity of Cervical Dystonia: Ask the Doctor or Ask the Patient?
Assessing the Severity of Cervical Dystonia: Ask the Doctor or Ask the Patient? Open
Background Assessing disease severity can be performed using either clinician‐rated scales (CRS) or patient‐rated outcome (PRO) tools. These two measures frequently demonstrate poor correlations. Objectives To determine if the correlation …
View article: From basic science to clinical practice: Can cognitive behavioural therapy tasks be augmented with enhanced episodic specificity?
From basic science to clinical practice: Can cognitive behavioural therapy tasks be augmented with enhanced episodic specificity? Open
Individuals with depression typically remember their past in a generalised manner, at the cost of retrieving specific event memories. This may impair engagement with cognitive behavioural therapy (CBT) tasks that use concrete episodic info…
View article: 0357 Pimavanserin 34mg at Bedtime for Insomnia in Veterans with Post-traumatic Stress Disorder: Open-label Case Series
0357 Pimavanserin 34mg at Bedtime for Insomnia in Veterans with Post-traumatic Stress Disorder: Open-label Case Series Open
Introduction There is a critical need for effective and feasible interventions to address insomnia associated with post-traumatic stress disorder (PTSD). Several lines of evidence suggest that pimavanserin, a 5-HT2A inverse agonist approve…
View article: Threat Analysis of Forest Fragmentation and Degradation for Peruvian Primates
Threat Analysis of Forest Fragmentation and Degradation for Peruvian Primates Open
Peru has 55 primate taxa (including all species and subspecies), a third of which are threatened. The major drivers of habitat loss, degradation and fragmentation are grazing, forestry, agriculture and transport infrastructure. Other activ…
View article: From basic science to clinical practice: Do Cognitive Behavioural Therapy tasks benefit from enhanced episodic specificity?
From basic science to clinical practice: Do Cognitive Behavioural Therapy tasks benefit from enhanced episodic specificity? Open
Individuals with depression typically remember their past in a generalised manner, at the cost of retrieving specific event memories. This may impair engagement with cognitive behavioural therapy (CBT) tasks that use concrete episodic info…
View article: Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study
Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study Open
Background We conducted this study to assess the prevalence of viral coinfection in a well characterized cohort of hospitalized coronavirus disease 2019 (COVID-19) patients and to investigate the impact of coinfection on disease severity. …
View article: Inhibition as a cause of forgetting
Inhibition as a cause of forgetting Open
Inhibitory control is a fundamental process that enables suppression of representations or processes that interfere with ongoing cognition and behavior. This chapter reviews the role of such control processes in causing forgetting from lon…
View article: Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission Open
Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium …
View article: Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study
Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study Open
COVID-19 is clinically characterised by fever, cough, and dyspnoea. Symptoms affecting other organ systems have been reported. However, it is the clinical associations of different patterns of symptoms which influence diagnostic and therap…
View article: Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study
Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study Open
Background Acute kidney injury (AKI) is common in coronavirus disease 2019 (COVID-19). This study investigated adults hospitalized with COVID-19 and hypothesized that risk factors for AKI would include comorbidities and non-White race. Met…
View article: Non‐motor phenotypic subgroups in adult‐onset idiopathic, isolated, focal cervical dystonia
Non‐motor phenotypic subgroups in adult‐onset idiopathic, isolated, focal cervical dystonia Open
Background : Non‐motor symptoms are well established phenotypic components of adult‐onset idiopathic, isolated, focal cervical dystonia (AOIFCD). However, improved understanding of their clinical heterogeneity is needed to better target th…