Laura Matarazzo
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View article: Neutrophil subsets enhance the efficacy of host-directed therapy in pneumococcal pneumonia
Neutrophil subsets enhance the efficacy of host-directed therapy in pneumococcal pneumonia Open
Host-directed therapy, using nasal administration of the Toll-like receptor 5 agonist flagellin in combination with antibiotics, has proven effective against pneumococcal pneumonia. In this study, we investigated the immune mechanisms unde…
View article: A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection
A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection Open
Several vaccines targeting bacterial pathogens show reduced efficacy upon concurrent viral infection, indicating that a new vaccinology approach is required. To identify antigens for the human pathogen Streptococcus pneumoniae that are eff…
View article: A conserved antigen induces respiratory Th17-mediated serotype-independent protection against pneumococcal superinfection
A conserved antigen induces respiratory Th17-mediated serotype-independent protection against pneumococcal superinfection Open
Summary Several vaccines targeting bacterial pathogens show reduced efficacy in the context of intercurrent viral infection indicating a new vaccinology approach is required to protect against such superinfections. To find antigens for the…
View article: Retinoic Acid–Related Orphan Receptor α Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation
Retinoic Acid–Related Orphan Receptor α Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation Open
The transcription factor retinoic acid–related orphan receptor α (RORα) is important in regulating several physiological functions, such as cellular development, circadian rhythm, metabolism, and immunity. In two in vivo animal models of t…
View article: mRNA vaccines: a new opportunity for malaria, tuberculosis and HIV
mRNA vaccines: a new opportunity for malaria, tuberculosis and HIV Open
The success of the first licensed mRNA-based vaccines against COVID-19 has created a widespread interest on mRNA technology for vaccinology. As expected, the number of mRNA vaccines in preclinical and clinical development increased exponen…
View article: The IL-1 cytokine family as custodians of barrier immunity
The IL-1 cytokine family as custodians of barrier immunity Open
The interleukin-1 (IL-1) family of cytokines and receptors are implicated in the functioning of innate and adaptive immunity and the genesis of inflammation. They are widely expressed in structural and immune cells with marked expression w…
View article: Exploration of Bacterial Bottlenecks and Streptococcus pneumoniae Pathogenesis by CRISPRi-Seq
Exploration of Bacterial Bottlenecks and Streptococcus pneumoniae Pathogenesis by CRISPRi-Seq Open
View article: Boosting Toll-like receptor 4 signaling enhances the therapeutic outcome of antibiotic therapy in pneumococcal pneumonia
Boosting Toll-like receptor 4 signaling enhances the therapeutic outcome of antibiotic therapy in pneumococcal pneumonia Open
The emergence and spread of antibiotic resistance emphasize the need for alternative treatment strategies against bacterial infections. Boosting the host innate immunity is not only readily deployable in most individuals but can also mobil…
View article: Anti-infectious properties of Toll-like receptor agonists in association with antibiotics in the treatment of lung infections
Anti-infectious properties of Toll-like receptor agonists in association with antibiotics in the treatment of lung infections Open
Les pneumonies bactériennes, notamment à Streptococcus pneumoniae,représentent la troisième cause de mortalité au niveau mondiale et la progression constantede la résistance aux antibiotiques complique la prise en charge des patients. La s…
View article: Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia
Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia Open
Bacterial infections of the respiratory tract constitute a major cause of death worldwide. Given the constant rise in bacterial resistance to antibiotics, treatment failure is increasingly frequent. In this context, innovative therapeutic …