Laura Morbiato
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View article: The OSCP Subunit of ATP Synthase is a Dimer in Solution: Strategy to Induce the Monomeric Protein as a New Tool for Drug Discovery
The OSCP Subunit of ATP Synthase is a Dimer in Solution: Strategy to Induce the Monomeric Protein as a New Tool for Drug Discovery Open
The F-ATP synthase subunit Oligomycin Sensitivity Conferral Protein (OSCP) contributes to the structural and functional coupling between the F1 catalytic and the FO transmembrane domains of the synthase. A body of lit…
View article: Structure Matters: Tailored Graphitization of Carbon Dots Enhances Photocatalytic Performance
Structure Matters: Tailored Graphitization of Carbon Dots Enhances Photocatalytic Performance Open
The chemical structure and photoredox properties of carbon dots (CDs) are not yet fully understood. However, it has been reported that, by carefully choosing the starting materials and tuning their synthesis conditions, it is possib…
View article: The Oscp Subunit of Atp Synthase is a Dimer in Solution: Implications for the Druggability of Mitochondrial Permeability Transition
The Oscp Subunit of Atp Synthase is a Dimer in Solution: Implications for the Druggability of Mitochondrial Permeability Transition Open
View article: COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic cells
COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic cells Open
View article: COQ4 is required for the oxidative decarboxylation of the C1 carbon of Coenzyme Q in eukaryotic cells
COQ4 is required for the oxidative decarboxylation of the C1 carbon of Coenzyme Q in eukaryotic cells Open
SUMMARY Coenzyme Q (CoQ) is a redox lipid that fulfills critical functions in cellular bioenergetics and homeostasis. CoQ is synthesized by a multi-step pathway that involves several COQ proteins. Two steps of the eukaryotic pathway, the d…
View article: Direct Comparison between Förster Resonance Energy Transfer and Light-Induced Triplet–Triplet Electron Resonance Spectroscopy
Direct Comparison between Förster Resonance Energy Transfer and Light-Induced Triplet–Triplet Electron Resonance Spectroscopy Open
To carry out reliable and comprehensive structural investigations, the exploitation of different complementary techniques is required. Here, we report that dual triplet-spin/fluorescent labels enable the first parallel distance measurement…
View article: Synthesis, Conformational Analysis and Antitumor Activity of the Naturally Occurring Antimicrobial Medium-Length Peptaibol Pentadecaibin and Spin-Labeled Analogs Thereof
Synthesis, Conformational Analysis and Antitumor Activity of the Naturally Occurring Antimicrobial Medium-Length Peptaibol Pentadecaibin and Spin-Labeled Analogs Thereof Open
Peptaibols are proteolysis-resistant, membrane-active peptides. Their remarkably stable helical 3D-structures are key for their bioactivity. They can insert themselves into the lipid bilayer as barrel staves, or lay on its surface like car…
View article: Protocell Communication through the Eyes of Synthetic Organic Chemists
Protocell Communication through the Eyes of Synthetic Organic Chemists Open
The bottom‐up fabrication of synthetic cells (protocells) from molecules and materials, is a major challenge of modern chemistry. A significant breakthrough has been the engineering of protocells capable of chemical communication using bio…
View article: Shining Light on Carbon Dots: New Opportunities in Photocatalysis
Shining Light on Carbon Dots: New Opportunities in Photocatalysis Open
Photocatalysis is an emerging field that exploits light‐absorbing catalysts to yield transformations not even achievable in the dark. Considering the drawbacks of metal‐based photocatalysts, Carbon Dots (CDs) recently emerged as suitable g…
View article: Peptide Analogs of a <i>Trichoderma</i> Peptaibol Effectively Control Downy Mildew in the Vineyard
Peptide Analogs of a <i>Trichoderma</i> Peptaibol Effectively Control Downy Mildew in the Vineyard Open
Plasmopara viticola, the agent of grapevine downy mildew, causes enormous economic damage, and its control is primarily based on the use of synthetic fungicides. The European Union policies promote reducing reliance on synthetic plant prot…
View article: Total synthesis of the natural, medium‐length, peptaibol pentadecaibin and study of the chemical features responsible for its membrane activity
Total synthesis of the natural, medium‐length, peptaibol pentadecaibin and study of the chemical features responsible for its membrane activity Open
Peptaibols are naturally occurring, antimicrobial peptides endowed with well‐defined helical conformations and resistance to proteolysis. Both features stem from the presence in their sequence of several, C α ‐tetrasubstituted, α‐aminoisob…
View article: Erythrosin B as a New Photoswitchable Spin Label for Light-Induced Pulsed EPR Dipolar Spectroscopy
Erythrosin B as a New Photoswitchable Spin Label for Light-Induced Pulsed EPR Dipolar Spectroscopy Open
We present a new photoswitchable spin label for light-induced pulsed electron paramagnetic resonance dipolar spectroscopy (LiPDS), the photoexcited triplet state of erythrosin B (EB), which is ideal for biological applications. With this l…
View article: Analogs of a Natural Peptaibol Exert Anticancer Activity in Both Cisplatin- and Doxorubicin-Resistant Cells and in Multicellular Tumor Spheroids
Analogs of a Natural Peptaibol Exert Anticancer Activity in Both Cisplatin- and Doxorubicin-Resistant Cells and in Multicellular Tumor Spheroids Open
Peptaibols, by disturbing the permeability of phospholipid membranes, can overcome anticancer drug resistance, but their natural hydrophobicity hampers their administration. By a green peptide synthesis protocol, we produced two water-solu…