Laura Ormesher
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View article: Maternal and fetal outcomes in subsequent pregnancies after peripartum cardiomyopathy: A systematic review and meta‐analysis
Maternal and fetal outcomes in subsequent pregnancies after peripartum cardiomyopathy: A systematic review and meta‐analysis Open
Introduction We aim to determine the pregnancy and cardiovascular outcomes of subsequent pregnancies following a previous diagnosis of peripartum cardiomyopathy. Material and Methods Medline, Embase, CINAHL, and Web of Science were searche…
View article: Pre-eclampsia and future cardiovascular disease risk: Assessing British clinicians’ knowledge and practice
Pre-eclampsia and future cardiovascular disease risk: Assessing British clinicians’ knowledge and practice Open
This study presents the first assessment of cardiovascular risk awareness after pre-eclampsia amongst UK-based clinicians. Although most knew pre-eclampsia increases CVD risk, patient counselling was limited. Targeted educational initiativ…
View article: The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester–A primary cohort study with a scoping review
The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester–A primary cohort study with a scoping review Open
Introduction Supine sleep position is associated with stillbirth, likely secondary to inferior vena cava compression, and a reduction in cardiac output (CO) and uteroplacental perfusion. Evidence for the effects of prone position in pregna…
View article: CHronic hypERtension and L-citRulline studY (CHERRY): an Early-Phase Randomised Controlled Trial in Pregnancy
CHronic hypERtension and L-citRulline studY (CHERRY): an Early-Phase Randomised Controlled Trial in Pregnancy Open
Oral supplementation with L-citrulline, which is sequentially converted to L-arginine then nitric oxide, improves vascular biomarkers and reduces blood pressure in non-pregnant, hypertensive human cohorts and pregnant mice with a pre-eclam…
View article: Altered Oral Nitrate Reduction and Bacterial Profiles in Hypertensive Women Predict Blood Pressure Lowering Following Acute Dietary Nitrate Supplementation
Altered Oral Nitrate Reduction and Bacterial Profiles in Hypertensive Women Predict Blood Pressure Lowering Following Acute Dietary Nitrate Supplementation Open
BACKGROUND: The efficacy of dietary nitrate supplementation to lower blood pressure (BP) in pregnant women is highly variable. We aimed to investigate whether differences in oral microbiota profiles and oral nitrate-reducing capacity may e…
View article: The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester – A primary cohort study with a scoping review
The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester – A primary cohort study with a scoping review Open
Introduction Supine sleep position is associated with stillbirth, likely secondary to inferior vena cava compression, and a reduction in cardiac output (CO) and uteroplacental perfusion. Evidence for the effects of prone position in pregna…
View article: Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study
Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study Open
Pre-eclampsia is associated with postnatal cardiac dysfunction; however, the nature of this relationship remains uncertain. This multicentre retrospective cohort study aimed to determine the prevalence of pre-eclampsia in women with pre-ex…
View article: Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study.
Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study. Open
Objective: To determine the prevalence of pre-eclampsia and fetal growth restriction (FGR; <3rd centile) in women with pre-existing cardiac dysfunction. Design: Retrospective cohort study. Setting: Maternity units in UK and Australia. Popu…
View article: Postnatal Enalapril to Improve Cardiovascular Function Following Preterm Preeclampsia (PICk-UP):
Postnatal Enalapril to Improve Cardiovascular Function Following Preterm Preeclampsia (PICk-UP): Open
Hypertensive disease in pregnancy is associated with future cardiovascular disease and, therefore, provides an opportunity to identify women who could benefit from targeted interventions aimed at reducing cardiovascular morbidity. This stu…
View article: ‘To test or not to test’, the arguments for and against thrombophilia testing in obstetrics
‘To test or not to test’, the arguments for and against thrombophilia testing in obstetrics Open
Clinicians increasingly investigate women for thrombophilias due to their associations with venous thromboembolism and placenta-mediated pregnancy complication. These associations, however, are modest and based largely on retrospective dat…
View article: Dietary interventions for fetal growth restriction – therapeutic potential of dietary nitrate supplementation in pregnancy
Dietary interventions for fetal growth restriction – therapeutic potential of dietary nitrate supplementation in pregnancy Open
Fetal growth restriction (FGR) affects around 5% of pregnancies and is associated with significant short‐ and long‐term adverse outcomes. A number of factors can increase the risk of FGR, one of which is poor maternal diet. In terms of pat…
View article: Management of inherited thrombophilia in pregnancy
Management of inherited thrombophilia in pregnancy Open
Adverse pregnancy outcomes, such as pregnancy loss and pre-eclampsia, are associated with thrombotic mechanisms and thrombophilia. Antithrombotic interventions, particularly low-molecular-weight heparin, have been investigated in women ide…
View article: ANXA5: A Key to Unlock the Mystery of the Spectrum of Placental-Mediated Pregnancy Complications?
ANXA5: A Key to Unlock the Mystery of the Spectrum of Placental-Mediated Pregnancy Complications? Open
Background Placental-mediated pregnancy complications, miscarriage, fetal growth restriction and preeclampsia are a spectrum of disorders sharing overlapping clinical and pathological features. All are associated with thrombotic pathogenic…
View article: Endometriosis and irritable bowel syndrome: a dilemma for the gynaecologist and gastroenterologist
Endometriosis and irritable bowel syndrome: a dilemma for the gynaecologist and gastroenterologist Open
Key content Chronic pelvic pain has a significant impact on health services, accounting for 20% of gynaecological referrals. The overlap between irritable bowel syndrome and endometriosis, two of the leading causes of chronic pelvic pain, …