Laura Pak
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View article: THE FREQUENCY AND EFFICACY ASSESSMENT OF RADIOIODINE THERAPY FOR DISTANT METASTASES OF THYROID CANCER
THE FREQUENCY AND EFFICACY ASSESSMENT OF RADIOIODINE THERAPY FOR DISTANT METASTASES OF THYROID CANCER Open
Introduction. In Kazakhstan, as well as globally, the incidence of thyroid cancer is increasing. In 2023 the incidence rate rose by 13.1% compared to the previous year. Radioactive iodine therapy (I-131) is the primary treatment method for…
View article: THE IMPACT OF GENE MUTATIONS IN THYROID CANCER: A REVIEW
THE IMPACT OF GENE MUTATIONS IN THYROID CANCER: A REVIEW Open
Introduction: Thyroid cancer is a common endocrine malignancy, with DICER1 mutations emerging as significant contributors to its development and progression. The identification of these mutations through molecular genetic analysis, particu…
View article: GENETIC ANALYSIS OF TP53 AND CTNNB1 MUTATIONS IN PEDIATRIC MEDULLOBLASTOMA: A STUDY FROM KAZAKHSTAN
GENETIC ANALYSIS OF TP53 AND CTNNB1 MUTATIONS IN PEDIATRIC MEDULLOBLASTOMA: A STUDY FROM KAZAKHSTAN Open
Background: Medulloblastoma is the most common malignant pediatric brain tumor, exhibiting significant genetic heterogeneity. Mutations in TP53 and CTNNB1 have been implicated in tumorigenesis, prognosis, and treatment response. However, t…
View article: THE CLINICAL FEATURES OF RADIOIODINE-RESISTANT DIFFERENTIATED THYROID CANCER: PRELIMINARY RESULTS
THE CLINICAL FEATURES OF RADIOIODINE-RESISTANT DIFFERENTIATED THYROID CANCER: PRELIMINARY RESULTS Open
Introduction. According to global statistics, thyroid cancer is the seventh most common cancer among all types of cancer. Thyroid cancer treatment using radioactive iodine effectively eliminates the remnants of thyroid tissue that accumula…
View article: RADIOIODINE-RESISTANT DIFFERENTIATED THYROID CANCER: CLINICOPATHOLOGICAL CHARACTERISTICS, MOLECULAR GENETIC ALTERATIONS. REVIEW.
RADIOIODINE-RESISTANT DIFFERENTIATED THYROID CANCER: CLINICOPATHOLOGICAL CHARACTERISTICS, MOLECULAR GENETIC ALTERATIONS. REVIEW. Open
Introduction. Thyroid cancer is one of the most common endocrine malignancies. Radioactive iodine I131 is the baseline drug in the therapy of patients with differentiated thyroid cancer (DTC); however, 5% to 15% of DTC and 50% of metastati…
View article: VALIDATION OF THE KAZAKH VERSION OF THE DEPRESSION ANXIETY STRESS SCALE (DASS-21) IN MEDICAL FACULTY STAFF SAMPLE: THE PILOT STUDY
VALIDATION OF THE KAZAKH VERSION OF THE DEPRESSION ANXIETY STRESS SCALE (DASS-21) IN MEDICAL FACULTY STAFF SAMPLE: THE PILOT STUDY Open
Background. According to the IHME data, 1 in 10 people in Kazakhstan suffer from mental disorders, predominantly depression and anxiety. Numerous studies of academic medicine have shown that faculty experience higher rates of psychological…
View article: Prevalence and Associated Factors of Depression, Anxiety, and Stress Among Academic Medicine Faculty in Kazakhstan: A Cross-sectional Study
Prevalence and Associated Factors of Depression, Anxiety, and Stress Among Academic Medicine Faculty in Kazakhstan: A Cross-sectional Study Open
Introduction: Psychological distress refers to a set of painful mental and physical symptoms of anxiety and depression, which often coexist and coincide with common somatic complaints and chronic conditions. In Kazakhstan, mental disorders…
View article: Validation of the Kazakh version of the Brief Index of Affective Job Satisfaction in medical universities faculty staff sample
Validation of the Kazakh version of the Brief Index of Affective Job Satisfaction in medical universities faculty staff sample Open
Aim: The present study aimed to perform validation and assessment of psychometric indicators of the Kazakh version of the Brief Index of Affective Job Satisfaction on the academic faculty staff. Material and methods: The translation of the…
View article: Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series
Restenosis of Coronary Arteries in Patients with Coronavirus Infection: Case Series Open
Introduction. Coronavirus infection is a risk factor for vascular thrombosis. This is of particular importance for patients undergoing myocardial revascularization since this infection can be a trigger for the formation of restenosis in th…
View article: Gene polymorphisms and serum levels of BDNF and CRH in vitiligo patients
Gene polymorphisms and serum levels of BDNF and CRH in vitiligo patients Open
Background Vitiligo is one of the most common hypomelanoses, in which the destruction of functioning melanocytes causes depigmentation of the skin, hair and mucous membranes. The genes encrypting brain-derived neurotrophic factor (BDNF) an…
View article: Associations between serum levels of brain-derived neurotrophic factor, corticotropin releasing hormone and mental distress in vitiligo patients
Associations between serum levels of brain-derived neurotrophic factor, corticotropin releasing hormone and mental distress in vitiligo patients Open
Vitiligo is clinically characterized by the appearance of non-symptomatic depigmented macules, but the disorder is highly correlated with a wide range of psychiatric disorders and psychological problems. The aim of our study was to investi…
View article: MODERN APPROACHES OF CERVICAL CANCERRADIATION TREATMENT. LITERATURE REVIEW.
MODERN APPROACHES OF CERVICAL CANCERRADIATION TREATMENT. LITERATURE REVIEW. Open
Introduction: Cervical cancer is one of the most common oncological diseases in the world, as well as one of the causes of death in the female population worldwide. The study and development of new areas of modern oncogynecology in locally…
View article: Structure of therapy and compliance of patients with severe arterial hypertension
Structure of therapy and compliance of patients with severe arterial hypertension Open
The purpose of the study was to determine the structure, compliance to antihypertensive pharmacotherapy in patients with arterial hypertension of the third degree in the conditions of Semey and the frequency of achieving target BP. The stu…
View article: Disorder of Endothelia Vessels' Functional State with Malignant Tumors in Patients Exposed Anthropogenic Radiation
Disorder of Endothelia Vessels' Functional State with Malignant Tumors in Patients Exposed Anthropogenic Radiation Open
The aim of this research is to determine the characteristics of endothelial factors and the hemostatic system conditions with malignant neoplasms patients, which were exposed to ionizing radiation. Total number of examined people is 223, 1…