Explanipedia

Design, Synthesis and Evaluation of the First 2-Alkynyl(aza)indole 18F Probe Targeting α-Synuclein Aggregates Open

Liliana Boiaryna, Laura Pieri, Sylvie Chalon, Sophie Sérrière, Sylvie Bodard , et al. · 2025

Background/Objectives: The role of α-synuclein (α-syn) in the pathogenesis of Parkinson’s disease (PD) or neurodegenerative diseases such as Lewy body dementia (LBD) and multiple system atrophy (MSA) is commonly accepted. Through different…

Genome Sequences of Microbacterium foliorum Phages BouleyBill and Carostasia, isolated in France Open

Christophe Regeard, Florence Constantinesco‐Becker, Anne Lopes, Ana‐Andreea Arteni, Malika Ouldali , et al. · 2025

Bacteriophages BouleyBill and Carostasia, exhibiting siphovirus morphology, were isolated in France. Both infected Microbacterium foliorum strain NRRL B-24224. Their 39,215-bp and 40,393-bp genomes were assigned to subclusters EA4 a…

Design, Synthesis and Evaluation of the First 2-Alkynyl(Aza)Indole 18f Probe Targeting Alpha Synuclein Aggregates Open

Liliana Boiaryna, Laura Pieri, Sylvie Chalon, Sophie Sérrière, Sylvie Bodard , et al. · 2025

High‐powered 675‐nm laser: Safety and efficacy in clinical evaluation and in vitro evidence for different skin disorders Open

Massimo DF Vitale, Francesca Madeddu, Irene Fusco, Laura Pieri, Paolo Bonan , et al. · 2024

Background Laser technology is a viable therapeutic option for treating a number of skin pathologic conditions, including pigmented lesions, vascular lesions and acne scars. Aim In this work, through in vitro and clinical investigations we…

Nonstructural protein 4 of human norovirus self-assembles into various membrane-bridging multimers Open

Adrien Royet, Rémi Ruedas, Laetitia Gargowitsch, Virginie Gervais, Johann Habersetzer , et al. · 2024

Single-stranded, positive-sense RNA ((+)RNA) viruses replicate their genomes in virus-induced intracellular membrane compartments. (+)RNA viruses dedicate a significant part of their small genomes (a few thousands to a few tens of thousand…

Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex Open

Rémi Ruedas, Rémi Vuillemot, Thibault Tubiana, Jean-Marie Winter, Laura Pieri , et al. · 2024

Oligomeric assembly of the C-terminal and transmembrane region of SARS-CoV-2 nsp3 Open

Marion Babot, Yves Boulard, Samira Agouda, Laura Pieri, Sonia Fieulaine , et al. · 2024

As for all single-stranded, positive-sense RNA (+RNA) viruses, intracellular RNA synthesis relies on extensive remodeling of host cell membranes that leads to the formation of specialized structures. In the case of severe acute respiratory…

Genome sequence of PSonyx, a singleton bacteriophage infecting Corynebacterium glutamicum Open

Ombeline Rossier, C Labarre, Anne Lopes, Monique Auberdiac, Kevin Tambosco , et al. · 2024

PSonyx is a newly isolated phage that infects Corynebacterium glutamicum. This siphovirus was isolated from a French pond in the south of Paris by students from Paris-Saclay University. Its 80,277-bp singleton genome carries 136 pro…

Q‐Switched 785 nm laser in the treatment of labial melanotic macules Open

Giustino Gallo, Shady M. Ibrahim, Beatrice Marina Pennati, Laura Pieri, Tiziano Zingoni , et al. · 2024

Physiological lip melanosis is a disorder with a multifactorial aetiology. It varies with ethnicity and is typical of people with darker skin tones. Benign conditions (ephelides, lentigines, labial melanotic macule), malignant instances (p…

Atomic structure and conformational variability of the HER2-trastuzumab-pertuzumab complex Open

Rémi Ruedas, Rémi Vuillemot, Thibault Tubiana, Winter JM, Laura Pieri , et al. · 2023

Laser emission at 675 nm: In vitro study evidence of a promising role in skin rejuvenation Open

Giada Magni, Laura Pieri, Irene Fusco, Francesca Madeddu, Tiziano Zingoni , et al. · 2023

A proteome scale study reveals how plastic surfaces and agitation promote protein aggregation Open

Marion Schvartz, Florent Saudrais, Stéphanie Devineau, Jean-Christophe Aude, Stéphane Chédin , et al. · 2023

Structure and Conformational Variability of the Her2-Trastuzumab-Pertuzumab Complex Open

Rémi Ruedas, Rémi Vuillemot, Thibault Tubiana, Jean-Marie Winter, Laura Pieri , et al. · 2023

1540-nm fractional laser treatment modulates proliferation and neocollagenesis in cultured human dermal fibroblasts Open

Giada Magni, Domenico Piccolo, Paolo Bonan, Claudio Conforti, Giuliana Crisman , et al. · 2022

OPINION article Front. Med., 18 October 2022Sec. Dermatology Volume 9 - 2022 | https://doi.org/10.3389/fmed.2022.1010878

Increased Immune Activation by Pathologic α‐Synuclein in Parkinson's Disease Open

Veselin Grozdanov, Luc Bousset, Michael Hoffmeister, Corinna Bliederhaeuser, Christoph A. Meier , et al. · 2019

Objective Excessive inflammation in the central nervous system (CNS) and the periphery can result in neurodegeneration and parkinsonism. Recent evidence suggests that immune responses in Parkinson disease patients are dysregulated, leading…

Clustering of Tau fibrils impairs the synaptic composition of α3‐Na + /K + ‐ ATP ase and AMPA receptors Open

Amulya Nidhi Shrivastava, Virginie Redeker, Laura Pieri, Luc Bousset, Marianne Renner , et al. · 2019

Tau assemblies have prion-like properties: they propagate from one neuron to another and amplify by seeding the aggregation of endogenous Tau. Although key in prion-like propagation, the binding of exogenous Tau assemblies to the plasma me…

Ridge Preservation Using an Innovative Enzyme-deantigenic Equine Bone Paste: A Case Report with 36-month Follow-up Open

Danilo Alessio Di Stefano, Lorenzo Cinci, Laura Pieri, Paolo Arosio · 2019

Alveolar ridge preservation using bone grafts is a well-known approach, yet there is still no agreement about which bone graft might be considered the most suitable for this indication. The novel equine-derived bone paste used in the prese…

Dendritic cells: a candidate cell in injury response to myocardial infarction and a possible diagnostic tool for sudden death Open

Stefano Bacci, Martina Focardi, Laura Pieri, Beatrice Defraia, Vilma Pinchi , et al. · 2017

Dendritic cells and mast cells are involved in the organization of inflammatory cell infiltrates in general, and in vascular wall in particular. The behaviour of these cells in myocardial infarction is still to be studied in detail. Myocar…

Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes Open

Saïda Abounit, Luc Bousset, Frida Loría, Seng Zhu, Fabrice de Chaumont , et al. · 2016

Structural and functional properties of prefibrillar α-synuclein oligomers Open

Laura Pieri, Karine Madiona, Ronald Melki · 2016

Data in support of the identification of neuronal and astrocyte proteins interacting with extracellularly applied oligomeric and fibrillar α-synuclein assemblies by mass spectrometry Open

Amulya Nidhi Shrivastava, Virginie Redeker, Nicolas Fritz, Laura Pieri, Leandro G. Almeida , et al. · 2016

α‐synuclein assemblies sequester neuronal α3‐Na + /K + ‐ ATP ase and impair Na + gradient Open

Amulya Nidhi Shrivastava, Virginie Redeker, Nicolas Fritz, Laura Pieri, Leandro G. Almeida , et al. · 2015

Dendritic cells infiltrate the cardiac muscle fibers during myocardial infarction Open

Stefano Bacci, Giulia Gonfiantini, Laura Pieri, Beatrice De Fraia, Paolo Romagnoli , et al. · 2015

Myocardial infarction (MI) consists in myocardial cell death due to prolonged ischemia. Partial ischemia at the periphery at the necrotic area may lead to “hibernating” myocardium, which may eventually recover. Upon necrosis an inflammator…

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