Laura Power
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Harnessing human adipose-derived stromal cell chondrogenesis in vitro for enhanced endochondral ossification Open
Endochondral ossification (ECO), the major ossification process during embryogenesis and bone repair, involves the formation of a cartilaginous template remodelled into a functional bone organ. Adipose-derived stromal cells (ASC), non-skel…
View article: Enhanced gene transfection efficacy and safety through granular hydrogel mediated gene delivery process
Enhanced gene transfection efficacy and safety through granular hydrogel mediated gene delivery process Open
Although gene therapy has made great achievements in both laboratory research and clinical translation, there are still challenges such as limited control of drug pharmacokinetics, acute toxicity, poor tissue retention, insufficient effica…
Machine Learning-Based Scoring System to Predict the Risk and Severity of Ataxic Speech Using Different Speech Tasks Open
The assessment of speech in Cerebellar Ataxia (CA) is time-consuming and requires clinical interpretation. In this study, we introduce a fully automated objective algorithm that uses significant acoustic features from time, spectral, cepst…
Biomarker Signatures of Quality for Engineering Nasal Chondrocyte-Derived Cartilage Open
Data underlying the figures in the publication “Biomarker Signatures of Quality for Engineering Nasal Chondrocyte-Derived Cartilage”, published in Front Bioeng Biotechnol., 2020, 8: 283. (DOI: 10.3389/fbioe.2020.00283). Table of contents: …
Biomarker Signatures of Quality for Engineering Nasal Chondrocyte-Derived Cartilage Open
Data underlying the figures in the publication “Biomarker Signatures of Quality for Engineering Nasal Chondrocyte-Derived Cartilage”, published in Front Bioeng Biotechnol., 2020, 8: 283. (DOI: 10.3389/fbioe.2020.00283). Table of contents: …
Deep learning enables the automation of grading histological tissue engineered cartilage images for quality control standardization Open
Using supervised deep learning, we could automate the scoring of histological images of engineered cartilage and achieve results with errors comparable to inter-user error. Thus, the model could enable the automation and standardization of…
Modeling the Progression of Speech Deficits in Cerebellar Ataxia Using a Mixture Mixed-Effect Machine Learning Framework Open
Background: Accurate and reliable prediction of changes in the severity of cerebellar ataxia (CA) will be necessary for trials of disease-modifying therapies. Cerebellar dysarthria (CD) is a common feature of CA. This study demonstrated th…
A Comprehensive Scheme for the Objective Upper Body Assessments of Subjects with Cerebellar Ataxia Open
BackgroundCerebellar Ataxia refers to the disturbance in movement resulting from cerebellar dysfunction. It manifests as inaccurate movements with delayed onset and overshoot, especially when movements are repetitive or rhythmic. Identific…
A Comprehensive Scheme for the Objective Upper Body Assessments of Subjects with Cerebellar Ataxia Open
Background Cerebellar ataxia (CA) is a complex motor disorder that exhibits various symptoms such as lack of movement accuracy, delayed motion and ataxic movements associated with gait, extremity and eye. Accurate assessment of ataxic move…
View article: Sensing tissue engineered cartilage quality with Raman spectroscopy and statistical learning for the development of advanced characterization assays
Sensing tissue engineered cartilage quality with Raman spectroscopy and statistical learning for the development of advanced characterization assays Open
Nasal chondrocyte-derived engineered cartilage has been demonstrated to be safe and feasible for the treatment of focal cartilage lesions with promising preliminary evidences of efficacy. To ensure the quality of the products and processes…
Biomarker Signatures of Quality for Engineering Nasal Chondrocyte-Derived Cartilage Open
The definition of quality controls for cell therapy and engineered product manufacturing processes is critical for safe, effective, and standardized clinical implementation. Using the example context of cartilage grafts engineered from aut…
Biomarker signatures of quality for nasal chondrocyte-derived engineered cartilage Open
The definition of quality controls for cell therapy and engineered product manufacturing processes is critical for safe, effective, and standardized clinical implementation. Using the example context of cartilage grafts engineered from aut…
Novel quality controls for nasal chondrocyte-derived tissue engineered cartilage Open
Cartilage defects are caused by injury, can be painful if left untreated, and may lead to degenerative joint diseases. Currently available treatments have not shown long-term predictable and durable results. Nasal chondrocytes have been in…
Mastering bioactive coatings of metal oxide nanoparticles and surfaces through phosphonate dendrons Open
Dendritic phosphonates are versatile coatings of several nanomaterials for health applications ranging from implants to nanoparticles and microbubbles.
Characteristics of assessment and treatment in Benign Paroxysmal Positional Vertigo (BPPV) Open
QUESTION: Benign Paroxysmal Positional Vertigo (BPPV) is the most common cause of dizziness presenting to specialist vestibular centres and accounts for approximately 20–30% of referrals to these clinics. In spite of the amount of clinical…
Quantitative assessment of cerebella ataxia through automated upper limb functional tests Open
Neurological disorders typically exhibit movement disabilities and disorders such as cerebellar ataxia (CA) can cause coordination inaccuracies often manifested as disabilities associated with gait, balance and speech. Since the severity a…
Quantitative assessment of cerebellar ataxia, through automated limb functional tests Open
Human Research and Ethics Committee, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia (HREC Reference Number: 11/994H/16).
Additional file 1 of Quantitative assessment of cerebellar ataxia, through automated limb functional tests Open
Data Analysis using signal parameters in page 5, Section: Data Analysis. (XLSX 10 kb)
Additional file 3 of Quantitative assessment of cerebellar ataxia, through automated limb functional tests Open
Statistical Analysis of the LDA outcomes in page 9, Section: Results. (XLSX 10.3 kb)
Metronidazole-functionalized iron oxide nanoparticles for molecular detection of hypoxic tissues Open
Functionalization of dendronized iron oxide nanoparticles with the bioreductive compound metronidazole for magnetic resonance imaging of hypoxic tissues.
Additional file 2 of Quantitative assessment of cerebellar ataxia, through automated limb functional tests Open
Pearson correlation values and P-values of extracted features in page 5, Section: Data Analysis. (XLSX 13.5 kb)
MOESM3 of A perfusion bioreactor-based 3D model of the subarachnoid space based on a meningeal tissue construct Open
Additional file 3: Figure S3. Gene ontology (GO) analysis of RNA sequencing. GO analysis of 980 differentially regulated genes sorted according to Process (A), Component (B) and Function (C). q-value indicating GO-term enrichment.
Quantification of Axial Abnormality Due to Cerebellar Ataxia with Inertial Measurements Open
Cerebellar Ataxia (CA) leads to deficiencies in muscle movement and lack of coordination that is often manifested as gait and balance disabilities. Conventional CA clinical assessments are subjective, cumbersome and provide less insight in…
Fourth ventricle ependymoma mimicking benign paroxysmal positional vertigo Open
A 57-year-old woman presented with a 4-month history of positional vertigo provoked by rolling to the left in bed. The patient was treated unsuccessfully by 3 clinicians for benign paroxysmal positional vertigo. The Dix-Hallpike maneuvre t…