Laura R. Loehr
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View article: Associations Between Cancer and Atrial Fibrillation: The Atherosclerosis Risk in Communities Study
Associations Between Cancer and Atrial Fibrillation: The Atherosclerosis Risk in Communities Study Open
In adult cancer patients, AF risk is the highest within 3 months after diagnosis and remains significantly elevated throughout survivorship but could be due to detection bias. Cancer risk is strongest within 3 months of AF diagnosis but si…
View article: Whole Genome Sequence Analysis of Pulmonary Function and COPD in 44,287 Multi-ancestry Participants
Whole Genome Sequence Analysis of Pulmonary Function and COPD in 44,287 Multi-ancestry Participants Open
Background Whole genome sequence (WGS) data in multi-ancestry samples provide the opportunity to identify low-frequency or population-specific genetic variants associated with chronic obstructive pulmonary disease (COPD) and lung function.…
View article: DNA methylation near <i>MAD1L1, KDM2B</i>, and <i>SOCS3</i> mediates the effect of socioeconomic status on elevated body mass index in African American adults
DNA methylation near <i>MAD1L1, KDM2B</i>, and <i>SOCS3</i> mediates the effect of socioeconomic status on elevated body mass index in African American adults Open
Obesity and poverty disproportionally affect African American persons. Epigenetic mechanisms could partially explain the association between socioeconomic disadvantage and body mass index (BMI). We examined the extent to which epigenetic m…
View article: Bundle branch blocks and the risk of mortality in the Atherosclerosis Risk in Communities study
Bundle branch blocks and the risk of mortality in the Atherosclerosis Risk in Communities study Open
Aims The main objective of our study was to evaluate the associations between different categories of bundle branch blocks (BBBs) and mortality and to consider possible impact of QRS prolongation in these associations. Methods This analysi…
View article: Metabolomic Association and Risk Prediction With Heart Failure in Older Adults
Metabolomic Association and Risk Prediction With Heart Failure in Older Adults Open
BACKGROUND: Older adults have markedly increased risks of heart failure (HF), specifically HF with preserved ejection fraction (HFpEF). Identifying novel biomarkers can help in understanding HF pathogenesis and improve at-risk population i…
View article: Prevalence of infertility and pregnancy loss among individuals with kidney disease in the Hispanic Community Health Study/Study of Latinos
Prevalence of infertility and pregnancy loss among individuals with kidney disease in the Hispanic Community Health Study/Study of Latinos Open
Background: Hispanic/Latino individuals are less likely to receive optimal treatment for chronic kidney disease than non-Hispanic whites. This may be particularly detrimental for women of reproductive age as chronic kidney disease increase…
View article: Cumulative socioeconomic status and incident type 2 diabetes among African American adults from the Jackson heart study
Cumulative socioeconomic status and incident type 2 diabetes among African American adults from the Jackson heart study Open
The association of low cumulative SES and incident T2D differed by age, which may suggest interventionist should consider impacts of SES on T2D by age.
View article: Cumulative socioeconomic status and incident type 2 diabetes among African American adults from the Jackson heart study
Cumulative socioeconomic status and incident type 2 diabetes among African American adults from the Jackson heart study Open
Background: The cumulative socioeconomic status (SES) model posits that childhood and adult experiences accumulate to influence disease risk. While individual SES indicators such as education and income are independently associated with in…
View article: Sex differences in progression of kidney disease in sickle cell disease
Sex differences in progression of kidney disease in sickle cell disease Open
Not available.
View article: Longitudinal study of glomerular hyperfiltration in adults with sickle cell anemia: a multicenter pooled analysis
Longitudinal study of glomerular hyperfiltration in adults with sickle cell anemia: a multicenter pooled analysis Open
Glomerular hyperfiltration is common in young sickle cell anemia patients and precedes development of overt kidney disease. In this multicenter pooled cohort, we characterized hyperfiltration and its decline to normal range in adult patien…
View article: Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study
Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study Open
Aims The aim is to evaluate associations of lung function impairment with risk of incident heart failure (HF). Methods and results Data were pooled across eight US population-based cohorts that enrolled participants from 1987 to 2004. Part…
View article: Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program
Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program Open
View article: Heart Failure Risk Associated With Severity of Modifiable Heart Failure Risk Factors: The ARIC Study
Heart Failure Risk Associated With Severity of Modifiable Heart Failure Risk Factors: The ARIC Study Open
There is an urgent need to improve heart failure (HF) prevention. Global cardiovascular health, as reflected by Life’s Simple 7, is linked to incident HF. However, the extent to which HF incidence might be mitigated by simultaneously optim…
View article: Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study
Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study Open
Aims: The aim is to evaluate associations of lung function impairment with risk of incident heart failure (HF). Methods and results: Data were pooled across eight US population-based cohorts that enrolled participants from 1987 to 2004. Pa…
View article: Frequent Premature Atrial Contractions Are Associated With Poorer Cognitive Function in the Atherosclerosis Risk in Communities (ARIC) Study
Frequent Premature Atrial Contractions Are Associated With Poorer Cognitive Function in the Atherosclerosis Risk in Communities (ARIC) Study Open
View article: Low Liver Enzymes and Risk of Dementia: The Atherosclerosis Risk in Communities (ARIC) Study
Low Liver Enzymes and Risk of Dementia: The Atherosclerosis Risk in Communities (ARIC) Study Open
Background: Low levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the low physiologic range, surrogate markers for reduced liver metabolic function, are associated with cerebral hypometabolism, impairment in …
View article: Low Liver Enzymes and Risk of Dementia: The Atherosclerosis Risk in Communities (ARIC) Study
Low Liver Enzymes and Risk of Dementia: The Atherosclerosis Risk in Communities (ARIC) Study Open
Background: Low levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the low physiologic range, surrogate markers for reduced liver metabolic function, are associated with cerebral hypometabolism, impairment in …
View article: Age-Dependent Associations Between 25-Hydroxy Vitamin D Levels and COPD Symptoms: Analysis of SPIROMICS
Age-Dependent Associations Between 25-Hydroxy Vitamin D Levels and COPD Symptoms: Analysis of SPIROMICS Open
When controlled for clinically relevant covariates, higher 25-OH-vitamin D levels are associated with more favorable respiratory-specific symptoms and quality-of-life assessments in middle-age but not older COPD individuals. Study of the r…
View article: Infertility and Pregnancy Loss in Hispanic/Latino Women with Chronic Kidney Disease: Results from the Hispanic Community Health Study/ Study of Latinos (HCHS/SOL)
Infertility and Pregnancy Loss in Hispanic/Latino Women with Chronic Kidney Disease: Results from the Hispanic Community Health Study/ Study of Latinos (HCHS/SOL) Open
Background: Hispanic/Latino individuals are less likely to receive optimal treatment for chronic kidney disease (CKD) than non-Hispanic whites. This may be particularly detrimental for women of reproductive age as CKD may increase risk for…
View article: Rapid decline in estimated glomerular filtration rate in sickle cell anemia: results of a multicenter pooled analysis
Rapid decline in estimated glomerular filtration rate in sickle cell anemia: results of a multicenter pooled analysis Open
Not available.
View article: Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function
Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function Open
Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV1), and its ratio to forced vital capacity (FEV1/FVC). Given that cigarette smo…
View article: High-sensitivity cardiac troponin T and the risk of incident atrial fibrillation: The Atherosclerosis Risk in Communities (ARIC) study
High-sensitivity cardiac troponin T and the risk of incident atrial fibrillation: The Atherosclerosis Risk in Communities (ARIC) study Open
Structural changes in the heart are known risk factors for atrial fibrillation (AF). An association between cardiac troponin T (hs-cTnT), a marker of myocardial cell damage measured with a high sensitivity assay, and the risk of AF could h…
View article: Association of Ventricular Arrhythmias With Dementia
Association of Ventricular Arrhythmias With Dementia Open
Presence of NSVT and a higher burden of NSVT and PVCs are associated with dementia in elderly Black people. Further research to confirm this novel finding and to elucidate the underlying mechanisms is warranted.
View article: Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants
Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants Open
View article: Predictors of Mortality by Sex and Race in Heart Failure With Preserved Ejection Fraction: ARIC Community Surveillance Study
Predictors of Mortality by Sex and Race in Heart Failure With Preserved Ejection Fraction: ARIC Community Surveillance Study Open
Background Heart failure with preserved ejection fraction (HFpEF) accounts for half of heart failure hospitalizations, with limited data on predictors of mortality by sex and race. We evaluated for differences in predictors of all‐cause mo…
View article: Infertility and Pregnancy Loss in Hispanic/Latino Women with Chronic Kidney Disease: Results from the Hispanic Community Health Study/ Study of Latinos (HCHS/SOL)
Infertility and Pregnancy Loss in Hispanic/Latino Women with Chronic Kidney Disease: Results from the Hispanic Community Health Study/ Study of Latinos (HCHS/SOL) Open
Background: Hispanic/Latino individuals are less likely to receive optimal treatment for chronic kidney disease (CKD) than non-Hispanic whites. This may be particularly detrimental for women of reproductive age as CKD may increase risk for…
View article: Mitochondrial DNA Copy Number and Incident Heart Failure
Mitochondrial DNA Copy Number and Incident Heart Failure Open
View article: Insulin resistance and reduced cardiac autonomic function in older adults: the Atherosclerosis Risk in Communities study
Insulin resistance and reduced cardiac autonomic function in older adults: the Atherosclerosis Risk in Communities study Open
View article: Associations Between Metabolic Syndrome and Longitudinal Respiratory Outcomes: The NHLBI Pooled Cohorts Study
Associations Between Metabolic Syndrome and Longitudinal Respiratory Outcomes: The NHLBI Pooled Cohorts Study Open
View article: Smoking Reduction Among Current Smokers and Cause-Specific Mortality: The NHLBI Pooled Cohorts Study
Smoking Reduction Among Current Smokers and Cause-Specific Mortality: The NHLBI Pooled Cohorts Study Open