Laura Silvestri
YOU?
Author Swipe
View article: When TNFα is out, IFN-γ drives anemia of inflammation
When TNFα is out, IFN-γ drives anemia of inflammation Open
View article: Targeting the Liver Serine Protease <scp>TMPRSS6</scp> Ameliorates Steatosis and Attenuates Fibrosis in Experimental <scp>MASLD</scp>
Targeting the Liver Serine Protease <span>TMPRSS6</span> Ameliorates Steatosis and Attenuates Fibrosis in Experimental <span>MASLD</span> Open
Background and Aims Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common cause of liver disease and a leading contributor to liver‐related morbidity and mortality. Currently, no pharmacological approach has d…
View article: Welcome to Blood Red Cells & Iron
Welcome to Blood Red Cells & Iron Open
View article: Bone phenotyping of murine hemochromatosis models with deficiencies of Hjv, Alk2, or Alk3: The influence of sex and the bone compartment
Bone phenotyping of murine hemochromatosis models with deficiencies of Hjv, Alk2, or Alk3: The influence of sex and the bone compartment Open
Osteopenia is frequently observed in patients with iron overload, especially in those with HFE ‐dependent hereditary hemochromatosis (HH). Interestingly, not all mouse models of HH show bone loss, suggesting that iron overload alone may no…
View article: Bone marrow <i>Tfr2</i> deletion improves the therapeutic efficacy of the activin‐receptor ligand trap RAP‐536 in β‐thalassemic mice
Bone marrow <i>Tfr2</i> deletion improves the therapeutic efficacy of the activin‐receptor ligand trap RAP‐536 in β‐thalassemic mice Open
β‐thalassemia is a disorder characterized by anemia, ineffective erythropoiesis (IE), and iron overload, whose treatment still requires improvement. The activin receptor‐ligand trap Luspatercept, a novel therapeutic option for β‐thalassemi…
View article: Ironing erythroid cells takes FLG1 and ERFE to tango
Ironing erythroid cells takes FLG1 and ERFE to tango Open
In this issue of Blood, Sardo et al expand our understanding of the interplay between erythropoiesis and iron metabolism. 1 They have identified fibrinogen-like protein 1 (FGL1) as a novel erythroid regulator produced by hepatocytes in res…
View article: Author Correction: Consensus Statement on the definition and classification of metabolic hyperferritinaemia
Author Correction: Consensus Statement on the definition and classification of metabolic hyperferritinaemia Open
View article: FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy
FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy Open
View article: Flavor of Iron at EHA2023: Novel Regulatory Mechanisms and Therapeutic Options for the Correction of Anemia
Flavor of Iron at EHA2023: Novel Regulatory Mechanisms and Therapeutic Options for the Correction of Anemia Open
At the Congress of the European Hematology Association (EHA) 2023 held in June in Frankfurt, Germany, 2 oral sessions were dedicated to iron metabolism and altered iron homeostasis in pathologic conditions. This HemaTopic will provide a ta…
View article: S285: DISSECTING THE ROLE OF THE IMMUNOPHILIN FKBP12 IN HEPCIDIN REGULATION
S285: DISSECTING THE ROLE OF THE IMMUNOPHILIN FKBP12 IN HEPCIDIN REGULATION Open
Background: The liver hormone hepcidin is the main regulator of iron metabolism. It controls body iron levels by blocking the cellular iron exporter ferroportin in response to increased serum and liver iron, and its deficiency is a common …
View article: S282: ERYTHROPOIESIS INDUCTION THROUGH BONE MARROW TFR2 DELETION REDUCES BLOOD GLUCOSE LEVELS IN WILD-TYPE AND Β-THALASSEMIC MICE
S282: ERYTHROPOIESIS INDUCTION THROUGH BONE MARROW TFR2 DELETION REDUCES BLOOD GLUCOSE LEVELS IN WILD-TYPE AND Β-THALASSEMIC MICE Open
Background: Β-Thalassemia is a genetic disease due to mutations in the β-globin gene characterized by anemia, ineffective erythropoiesis (IE), splenomegaly and iron-overload. Glucose intolerance and diabetes are common complications, usual…
View article: P1491: THE DYNAMIC INTERACTION BETWEEN INFLAMMATION AND THE IRON SENSOR HFE, IN SEVERE MALARIA-INDUCED ANEMIA
P1491: THE DYNAMIC INTERACTION BETWEEN INFLAMMATION AND THE IRON SENSOR HFE, IN SEVERE MALARIA-INDUCED ANEMIA Open
Topic: 29. Iron metabolism, deficiency and overload Background: Severe malarial anemia (SMA) is a complication developed during Plasmodium infection. It is often associated with increased rates of malaria-related morbidity and mortality, e…
View article: Table of Contents
Table of Contents Open
View article: Cellular and animal models for the investigation of β-thalassemia
Cellular and animal models for the investigation of β-thalassemia Open
β-Thalassemia is a genetic form of anemia due to mutations in the β-globin gene, that leads to ineffective and extramedullary erythropoiesis, abnormal red blood cells and secondary iron-overload. The severity of the disease ranges from mil…
View article: <scp>FKBP12</scp> inhibits hepcidin expression by modulating <scp>BMP</scp> receptors interaction and ligand responsiveness in hepatocytes
<span>FKBP12</span> inhibits hepcidin expression by modulating <span>BMP</span> receptors interaction and ligand responsiveness in hepatocytes Open
The expression of the iron regulatory hormone hepcidin in hepatocytes is regulated by the BMP‐SMAD pathway through the type I receptors ALK2 and ALK3, the type II receptors ACVR2A and BMPR2, and the ligands BMP2 and BMP6. We previously ide…
View article: Consensus Statement on the definition and classification of metabolic hyperferritinaemia
Consensus Statement on the definition and classification of metabolic hyperferritinaemia Open
View article: Managing the Dual Nature of Iron to Preserve Health
Managing the Dual Nature of Iron to Preserve Health Open
Because of its peculiar redox properties, iron is an essential element in living organisms, being involved in crucial biochemical processes such as oxygen transport, energy production, DNA metabolism, and many others. However, its propensi…
View article: <i>Transferrin receptor 2 (Tfr2)</i> genetic deletion makes transfusion‐independent a murine model of transfusion‐dependent β‐thalassemia
<i>Transferrin receptor 2 (Tfr2)</i> genetic deletion makes transfusion‐independent a murine model of transfusion‐dependent β‐thalassemia Open
β‐thalassemia is a genetic disorder caused by mutations in the β‐globin gene, and characterized by anemia, ineffective erythropoiesis and iron overload. Patients affected by the most severe transfusion‐dependent form of the disease (TDT) r…
View article: P1597: THE DYNAMIC INTERACTION BETWEEN INFLAMMATION AND IRON SENSORS IN MALARIA-INDUCED ANEMIA
P1597: THE DYNAMIC INTERACTION BETWEEN INFLAMMATION AND IRON SENSORS IN MALARIA-INDUCED ANEMIA Open
Background: Severe malarial anemia (SMA) is a complication developed during Plasmodium infection. It is often associated with increased rates of malaria-related morbidity and mortality, especially in children and pregnant women. Hence, it …
View article: P1509: BONE MARROW TFR2 GENETIC DELETION ABROGATES BLOOD TRANFUSION REQUIREMENT IN THE HBBTH1/TH2 Β-THALASSEMIC MURINE MODEL
P1509: BONE MARROW TFR2 GENETIC DELETION ABROGATES BLOOD TRANFUSION REQUIREMENT IN THE HBBTH1/TH2 Β-THALASSEMIC MURINE MODEL Open
Background: β-thalassemia is a genetic disorder caused by mutations in the β-globin gene, characterized by anemia, due to defective production of hemoglobin (Hb) and red blood cells (RBC), ineffective erythropoiesis (IE) and iron overload,…
View article: The mutual crosstalk between iron and erythropoiesis
The mutual crosstalk between iron and erythropoiesis Open
View article: CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study
CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study Open
View article: Hepcidin levels predict <scp>Covid‐19</scp> severity and mortality in a cohort of hospitalized Italian patients
Hepcidin levels predict <span>Covid‐19</span> severity and mortality in a cohort of hospitalized Italian patients Open
The hallmark of severe Covid-19, a recently described systemic disease caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), is the acute activation of the innate immune system associated with a prothrombotic state.1 The clinical …
View article: Cell‐type‐specific insights into iron regulatory processes
Cell‐type‐specific insights into iron regulatory processes Open
Despite its essential role in many biological processes, iron is toxic when in excess due to its propensity to generate reactive oxygen species. To prevent diseases associated with iron deficiency or iron loading, iron homeostasis must be …
View article: Targeted re-sequencing in malformations of cortical development: genotype-phenotype correlations
Targeted re-sequencing in malformations of cortical development: genotype-phenotype correlations Open
View article: NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice
NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice Open
The Nuclear Receptor Coactivator 4 (NCOA4) promotes ferritin degradation and Ncoa4-ko mice in C57BL/6 background show microcytosis and mild anemia, aggravated by iron deficiency. To understand tissue specific contribution of NCOA4-mediated…
View article: Hemochromatosis proteins are dispensable for the acute hepcidin response to BMP2
Hemochromatosis proteins are dispensable for the acute hepcidin response to BMP2 Open
View article: Iron metabolism and iron disorders revisited in the hepcidin era
Iron metabolism and iron disorders revisited in the hepcidin era Open
Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post-transcriptionally control genes encoding protei…
View article: Hepcidin and Anemia: A Tight Relationship
Hepcidin and Anemia: A Tight Relationship Open
Hepcidin, the master regulator of systemic iron homeostasis, tightly influences erythrocyte production. High hepcidin levels block intestinal iron absorption and macrophage iron recycling, causing iron restricted erythropoiesis and anemia.…
View article: Tamoxifen erythroid toxicity revealed by studying the role of nuclear receptor co-activator 4 in erythropoiesis
Tamoxifen erythroid toxicity revealed by studying the role of nuclear receptor co-activator 4 in erythropoiesis Open