Laura Steiger
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View article: Protocol for isolation and spectral flow cytometry analysis of immune cells from the murine exocrine and endocrine pancreas
Protocol for isolation and spectral flow cytometry analysis of immune cells from the murine exocrine and endocrine pancreas Open
Diabetes mellitus is a disease of the hormone-secreting endocrine pancreas. However, increasing evidence suggests that the exocrine pancreas is also involved in the pathogenesis of diabetes. In this protocol, we describe how to harvest bot…
View article: Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity
Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity Open
The obesity epidemic continues to worsen worldwide. However, the mechanisms initiating glucose dysregulation in obesity remain poorly understood. We assessed the role that colonic macrophage subpopulations play in glucose homeostasis in mi…
View article: β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion
β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion Open
Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet …