Explanipedia

External validation of PreOpNet to predict 30-day mortality after major non-cardiac surgery using digital electrocardiogram Open

A. Champetier, Pedro López‐Ayala, Christian Puelacher, Koray Durak, E. Kaplan , et al. · 2025

PreOpNet is a novel deep-learning algorithm using 12-lead digital electrocardiogram (ECG) for preoperative risk assessment of all-cause death and major adverse cardiac events (MACE) within 30 days. Its performance in European high-risk pat…

Comparison of Propofol and Dexmedetomidine Infused Overnight to Treat Hyperactive and Mixed ICU Delirium: A Prospective Randomised Controlled Clinical Trial Open

Stefan Zimmermann, Alexa Hollinger, Rita Achermann, Stefanie von Felten, Raoul Sutter , et al. · 2025

Background: Delirium is a frequent yet pathophysiologically still poorly understood complication in the intensive care unit (ICU) and is associated with adverse outcomes for the patients. Currently, guidelines give several recommendations …

Protocol for implementation of intraoperative adverse event recording during WHO checklist sign-out Open

Katrin Burri‐Winkler, Anne C Auderset, Dieter Hahnloser, Christoph Burkhart, Valentin Neuhaus , et al. · 2025

Introduction & aim Intraoperative adverse events (iAEs) increase postoperative complications, which are devastating to patients and costly to healthcare systems. To optimise patient outcomes, the WHO Surgical Safety Checklist (WHO SSC) was…

When and what patients need to know about AI in clinical care Open

David Shaw, Giorgia Lorenzini, Laura Arbelaez Ossa, Jens Eckstein, Luzius A. Steiner , et al. · 2025

In this article, we describe and analyse when and what patients need to be told about the use of artificial intelligence in clinical care. In many circumstances, patients do not need to be told about the use of AI, but in cases in which AI…

Like milk on the stove: Healthcare professionals navigating uncertainty when caring for families with 22q11DS Open

Sophie Ayoub, Eva De Clercq, Cheryl Cytrynbaum, Luzius A. Steiner, Bernice S. Elger · 2025

Introduction 22q11 deletion syndrome (22q11DS) results from a microdeletion on chromosome 22 and is the most common microdeletion disorder in humans, affecting 1 in 2148 live births. Clinical manifestations vary widely among individuals an…

Multicentre External Validation of the Machine Learning-Based PIPRA Predictive Model for Postoperative Delirium in Elderly Patients Open

Nayeli Schmutz, Kelly Reeve, John G. Gaudet, Bernhard Walder, Thomas Saller , et al. · 2025

Transition services in 22q11 deletion syndrome: Hit or miss Open

Sophie Ayoub, Sandra Meier, Cheryl Cytrynbaum, Ann Swillen, Luzius A. Steiner , et al. · 2025

Validation of the American College of Surgeons surgical risk calculator for thoracic surgery Open

Nikolay Tsvetkov, Makhmudbek Mallaev, Brigitta Gahl, Aljaž Hojski, Michael Tamm , et al. · 2024

The ACS NSQIP surgical risk calculator exhibited low sensitivity, specificity, and low AUROC for postoperative 30-day morbidity and mortality in our study cohort. Therefore, we think it cannot be considered as valid risk estimation tool fo…

The number of comorbidities as an important cofactor to <span>ASA</span> class in predicting postoperative outcome: An international multicentre cohort study Open

Christian A. Grob, Luzius W. Angehrn, Mark Kaufmann, Dieter Hahnloser, Michaël Winiker , et al. · 2024

Background Multimorbidity is a growing burden in our ageing society and is associated with perioperative morbidity and mortality. Despite several modifications to the ASA physical status classification, multimorbidity as such is still not …

Targeted temperature control following traumatic brain injury: ESICM/NACCS best practice consensus recommendations Open

Andrea Lavinio, Jonathan Coles, Chiara Robba, Marcel Aries, Pierre Bouzat , et al. · 2024

Aims and scope The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and require admissio…

Targeted Temperature Management following Traumatic Brain Injury: ESICM / NACCS Consensus Recommendations Guidelines Open

Andrea Lavinio, Jonathan Coles, Chiara Robba, Marcel Aries, Pierre Bouzat , et al. · 2024

Background The aim of this panel was to develop consensus recommendations and guidance on targeted temperature management (TTM) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and requ…

Olanzapine for extended-release injectable suspension (TV-44749) for subcutaneous use demonstrated to be robust to extreme injection site manipulations in rats Open

David Bibi, Luzius A. Steiner, Hussein Hallak · 2024

Is crystalloid co-loading necessary to prevent spinal hypotension during elective cesarean delivery? A randomized double-blind trial Open

B Buddeberg, Esther Seeberger, Claudio Blasi, Gilles Dutilh, Luzius A. Steiner , et al. · 2023

Omission of crystalloid co-loading leads to a decrease in cardiac output which has a potentially unfavorable impact on neonatal acid base status. We conclude that crystalloid co-loading may be useful in the presence of phenylephrine infusi…

How to avoid intraoperative complications of active paragangliomas? Open

Edvin Zekaj, Marcella Callea, Christian Saleh, Guglielmo Iess, Phillip Jaszczuk , et al. · 2023

Background: Paragangliomas (PGs) are very rare neuroendocrine tumors that can be found in unusual locations such as the spinal canal. Some PGs may be endocrinologically active, containing neurotransmitters such as noradrenaline, adrenaline…

Hydroxyethyl starch and Ringer’s lactate for volume resuscitation in sepsis and septic shock – The BaSES Trial Open

Alexa Hollinger, Stefanie von Felten, G Balestra, Michael Dickenmann, Luzius A. Steiner , et al. · 2023

Study objective: Shock develops in one third of ICU patients. Uncertainty remains about the ideal amount and choice of resuscitation fluid to avoid consequences of fluid overload. Design: The BaSES (Ba sel S tarch E valuation in S epsis) T…

Inaugural State of the Union: Continuous Cerebral Autoregulation Monitoring in the Clinical Practice of Neurocritical Care and Anesthesia Open

Soojin Park, Erta Beqiri, Peter Smielewski, Marcel Aries, Francisco Abecasis , et al. · 2023

Prediction of perioperative myocardial infarction/injury in high-risk patients after noncardiac surgery Open

Rebecca Meister, Christian Puelacher, Noemi Glarner, Danielle Menosi Gualandro, Henrik Andersson , et al. · 2023

Aims Perioperative myocardial infarction/injury (PMI) is a surprisingly common yet difficult-to-predict cardiac complication in patients undergoing noncardiac surgery. We aimed to assess the incremental value of preoperative cardiac tropon…

Long-term outcomes of perioperative myocardial infarction/injury after non-cardiac surgery Open

Christian Puelacher, Danielle Menosi Gualandro, Noemi Glarner, Giovanna Lurati Buse, Andreas Lampart , et al. · 2023

Aims Perioperative myocardial infarction/injury (PMI) following non-cardiac surgery is a frequent cardiac complication. Better understanding of the underlying aetiologies and outcomes is urgently needed. Methods and results Aetiologies of …

Acute heart failure after non‐cardiac surgery: incidence, phenotypes, determinants and outcomes Open

Danielle Menosi Gualandro, Christian Puelacher, Michelle S. Chew, Henrik Andersson, Giovanna Lurati Buse , et al. · 2023

Aims Primary acute heart failure (AHF) is a common cause of hospitalization. AHF may also develop postoperatively (pAHF). The aim of this study was to assess the incidence, phenotypes, determinants and outcomes of pAHF following non‐cardia…

Reporting Essentials for DElirium bioMarker Studies (REDEEMS): Explanation and Elaboration Open

Ingrid Amgarth‐Duff, Annmarie Hosie, Gideon A. Caplan, Dimitrios Adamis, Leiv Otto Watne , et al. · 2022

Despite many studies of potential delirium biomarkers, delirium pathophysiology remains unclear. Evidence shows that the quality of reporting delirium biomarker studies is sub-optimal. Better reporting of delirium biomarker studies is need…

Independent External Validation of a Preoperative Prediction Model for Delirium After Cardiac Surgery: A Prospective Observational Cohort Study Open

Alexandra S. Wueest, Manfred Berres, Dominique Béttex, Luzius A. Steiner, Andreas U. Monsch , et al. · 2022

Conversion between the Montreal Cognitive Assessment and the <span>Mini‐Mental</span> Status Examination Open

Jael S. Fasnacht, Alexandra S. Wueest, Manfred Berres, Alessandra E. Thomann, Sabine Krumm , et al. · 2022

Background Early and accurate detection of cognitive changes using simple tools is essential for an appropriate referral to a more detailed neurocognitive assessment and for the implementation of therapeutic strategies. The Mini‐Mental Sta…

Renal failure: a non-cardiac source of high sensitivity cardiac troponin T Open

Androniki Papachristou, Christian Puelacher, Noemi Glarner, Ivo Strebel, Jürg Steiger , et al. · 2022

Background Circulating high sensitivity cardiac troponin T (hs-cTnT) levels are frequently elevated in patients with end-stage renal disease (ESRD). The underlying pathophysiology is largely unknown. Currently, accumulation of hs-cTnT due …

Comparing propofol anaesthesia guided by Bispectral Index monitoring and frontal EEG wave analysis with standard monitoring in laparoscopic surgery: protocol for the ‘EEG in General Anaesthesia - More Than Only a Bispectral Index’ Trial, a multicentre, double-blind, randomised controlled trial Open

Bettina Ursina Gruber, Valerie Girsberger, Lukas Kusstatscher, Simon Funk, Anita Luethy , et al. · 2022

Introduction The use of Bispectral Index (BIS) monitors for assessing depth of sedation has led to a reduction in both the incidence of awareness and anaesthetic consumption in total intravenous anaesthesia. However, these monitors are vul…

Number of comorbidities and their impact on perioperative outcome and costs – a single centre cohort study Open

Loris Cavalli, Luzius W. Angehrn, Christian Schindler, Niccolò Orsini, Christian A. Grob , et al. · 2022

AIMS OF THE STUDY: Multimorbidity is a growing global health problem, resulting in an increased perioperative risk for surgical patients. Data on both the prevalence of multimorbidity and its impact on perioperative outcome are limited. Th…

Cardiovascular imaging following perioperative myocardial infarction/injury Open

Ketina Arslani, Danielle Menosi Gualandro, Christian Puelacher, Giovanna Lurati Buse, Andreas Lampart , et al. · 2022

Wireless wearables for postoperative surveillance on surgical wards: a survey of 1158 anaesthesiologists in Western Europe and the USA Open

Frédèric Michard, Robert H. Thiele, Bernd Saugel, Alexandre Joosten, Moritz Flick , et al. · 2022

Continuous monitoring of vital signs with wireless sensors is wanted by most anaesthesiologists from university hospitals in Western Europe and in the USA. They believe it may improve patient safety and outcome, but may also be challenging…

Classification of intraoperative adverse events in visceral surgery Open

Larsa Gawria, Rachel Rosenthal, Harry van Goor, Salome Dell‐Kuster, Richard B ten Broek , et al. · 2022

Role of Transcranial Doppler in Cardiac Surgery Patients Open

Pranav Gupta, Luzius A. Steiner · 2021

Purpose of Review This review discusses applications of transcranial Doppler (TCD) in cardiac surgery, its efficacy in preventing adverse events such as postoperative cognitive decline and stroke, and its impact on clinical outcomes in the…

Cardiovascular Imaging Following Perioperative Myocardial Infarction/Injury Open

Ketina Arslani, Danielle Menosi Gualandro, Christian Puelacher, Giovanna Lurati Buse, Andreas Lampart , et al. · 2021

Background : Patients developing perioperative myocardial infarction/injury(PMI) have high mortality. PMI work-up and therapy remain poorly defined. Methods : In a prospective multicenter study enrolling high-risk patients undergoing major…

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