Laura Usselmann
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View article: TimeTeller: A tool to probe the circadian clock as a multigene dynamical system
TimeTeller: A tool to probe the circadian clock as a multigene dynamical system Open
Recent studies have established that the circadian clock influences onset, progression and therapeutic outcomes in a number of diseases including cancer and heart diseases. Therefore, there is a need for tools to measure the functional sta…
View article: Thermal unfolding methods in drug discovery
Thermal unfolding methods in drug discovery Open
Thermal unfolding methods, applied in both isolated protein and cell-based settings, are increasingly used to identify and characterize hits during early drug discovery. Technical developments over recent years have facilitated their appli…
View article: TimeTeller: a tool to probe the circadian clock as a multigene dynamical system
TimeTeller: a tool to probe the circadian clock as a multigene dynamical system Open
A bstract Recent studies have established that the circadian clock influences onset, progression and therapeutic outcomes in a number of diseases including cancer and heart diseases. Therefore, there is a need for tools to measure the func…
View article: Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection
Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection Open
Sleep and circadian rhythm disruption (SCRD), as encountered during shift work, increases the risk of respiratory viral infection including SARS-CoV-2. However, the mechanism(s) underpinning higher rates of respiratory viral infection foll…
View article: Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection
Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection Open
Sleep and circadian rhythm disruption (SCRD), as encountered during shift work, increases the risk of respiratory viral infection including SARS-CoV-2. However, the mechanism(s) underpinning higher rates of respiratory viral infection foll…
View article: Cancer clocks in tumourigenesis: the p53 pathway and beyond
Cancer clocks in tumourigenesis: the p53 pathway and beyond Open
Circadian rhythms regulate a vast array of physiological and cellular processes, as well as the hormonal milieu, to keep our cells synchronised to the light–darkness cycle. Epidemiologic studies have implicated circadian disruption in the …