Laura Uva
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View article: Bestrophin1-mediated GABA release activates large chloride currents to generate epileptiform events in the entorhinal cortex
Bestrophin1-mediated GABA release activates large chloride currents to generate epileptiform events in the entorhinal cortex Open
The mechanisms that lead to the onset of a focal seizure are still not understood. We used the well-established 4-aminopyridine (4AP) ictogenesis model to analyze epileptiform discharges in the entorhinal cortex of rodents maintained in vi…
View article: Ultrasound guided blood brain barrier opening using a diagnostic probe in a whole brain model
Ultrasound guided blood brain barrier opening using a diagnostic probe in a whole brain model Open
The blood-brain barrier (BBB) poses a significant challenge to drug delivery to the brain. A promising approach involves low-frequency, low-intensity pulsed ultrasound (US) waves combined with intravenously injected microbubbles (MB) to te…
View article: Fast activity <i>chirp</i> patterns in focal seizures from patients and animal models
Fast activity <i>chirp</i> patterns in focal seizures from patients and animal models Open
Time–frequency analysis of focal seizure electroencephalographic signals performed with depth electrodes in human temporal lobe structures has revealed the occurrence at onset of oscillations at approximately 30–100 Hz that feature a monot…
View article: Ligand-gated mechanisms leading to ictogenesis in focal epileptic disorders
Ligand-gated mechanisms leading to ictogenesis in focal epileptic disorders Open
We review here the neuronal mechanisms that cause seizures in focal epileptic disorders and, specifically, those involving limbic structures that are known to be implicated in human mesial temporal lobe epilepsy. In both epileptic patients…
View article: Limbic and olfactory cortical circuits in focal seizures
Limbic and olfactory cortical circuits in focal seizures Open
Epilepsies affecting the limbic regions are common and generate seizures often resistant to pharmacological treatment. Clinical evidence demonstrates that diverse regions of the mesial portion of the temporal lobe participate in limbic sei…
View article: GABAA signaling, focal epileptiform synchronization and epileptogenesis
GABAA signaling, focal epileptiform synchronization and epileptogenesis Open
Under physiological conditions, neuronal network synchronization leads to different oscillatory EEG patterns that are associated with specific behavioral and cognitive functions. Excessive synchronization can, however, lead to focal or gen…
View article: dataset relate to article "A hypothesis for the role of axon demyelination in seizure generation"
dataset relate to article "A hypothesis for the role of axon demyelination in seizure generation" Open
Dataset contains raw data underlying figures 1,2 and 3 included in the publication mentioned at title
View article: dataset relate to article "A hypothesis for the role of axon demyelination in seizure generation"
dataset relate to article "A hypothesis for the role of axon demyelination in seizure generation" Open
Dataset contains raw data underlying figures 1,2 and 3 included in the publication mentioned at title
View article: Ultrasounds induce blood–brain barrier opening across a sonolucent polyolefin plate in an in vitro isolated brain preparation
Ultrasounds induce blood–brain barrier opening across a sonolucent polyolefin plate in an in vitro isolated brain preparation Open
The blood–brain barrier (BBB) represents a major obstacle to the delivery of drugs to the central nervous system. The combined use of low-intensity pulsed ultrasound waves and intravascular microbubbles (MB) represents a promising solution…
View article: Dataset related to article " Mapping region-specific seizure-like patterns in the in vitro isolated guinea pig brain"
Dataset related to article " Mapping region-specific seizure-like patterns in the in vitro isolated guinea pig brain" Open
Raw data and statistical analysis of the experiments of the paper. they describe the typical and specific seizure-like activity recorded in the isolated guinea pig brains after application of the two proconvulsant bicuculline and 4-aminopy…
View article: Dataset related to article " Mapping region-specific seizure-like patterns in the in vitro isolated guinea pig brain"
Dataset related to article " Mapping region-specific seizure-like patterns in the in vitro isolated guinea pig brain" Open
Raw data and statistical analysis of the experiments of the paper. they describe the typical and specific seizure-like activity recorded in the isolated guinea pig brains after application of the two proconvulsant bicuculline and 4-aminopy…
View article: Data related article "Activity- and pH-dependent adenosine shifts at the end of a focal seizure in the entorhinal cortex "
Data related article "Activity- and pH-dependent adenosine shifts at the end of a focal seizure in the entorhinal cortex " Open
Recording of seizures and assessment of extracellular pH and adenosine changes in the medial entorhinal cortex of isolated guinea pig brains maintained in vitro. Seizures were induced acutely by arterial perfusion of bicuculline or 4-amino…
View article: Data related article "Activity- and pH-dependent adenosine shifts at the end of a focal seizure in the entorhinal cortex "
Data related article "Activity- and pH-dependent adenosine shifts at the end of a focal seizure in the entorhinal cortex " Open
Recording of seizures and assessment of extracellular pH and adenosine changes in the medial entorhinal cortex of isolated guinea pig brains maintained in vitro. Seizures were induced acutely by arterial perfusion of bicuculline or 4-amino…
View article: Recording Electrical Brain Activity with Novel Stretchable Electrodes Based on Supersonic Cluster Beam Implantation Nanotechnology on Conformable Polymers
Recording Electrical Brain Activity with Novel Stretchable Electrodes Based on Supersonic Cluster Beam Implantation Nanotechnology on Conformable Polymers Open
Vadym Gnatkovsky,1 Alessandro Cattalini,1 Alessandro Antonini,2 Laura Spreafico,2 Matteo Saini,2 Francesco Noè,1 Camilla Alessi,1 Laura Librizzi,1 Laura Uva,1 Carlo Efisio Marras,3 Marco de Curtis,1 Sandro Ferrari2 1Unit of Epileptology, F…
View article: <p>Recording Electrical Brain Activity with Novel Stretchable Electrodes Based on Supersonic Cluster Beam Implantation Nanotechnology on Conformable Polymers</p>
Recording Electrical Brain Activity with Novel Stretchable Electrodes Based on Supersonic Cluster Beam Implantation Nanotechnology on Conformable Polymers Open
We confirm the biocompatibility of novel SCBI-based stretchable electrode devices and demonstrate their suitability for recording electrical brain activity in pre-clinical settings.
View article: Enhanced thalamo‐hippocampal synchronization during focal limbic seizures
Enhanced thalamo‐hippocampal synchronization during focal limbic seizures Open
Summary Objective The key factors that promote the termination of focal seizures have not been fully clarified. The buildup of neuronal synchronization during seizures has been proposed as one of the possible activity‐dependent, self‐limit…
View article: A Novel Focal Seizure Pattern Generated in Superficial Layers of the Olfactory Cortex
A Novel Focal Seizure Pattern Generated in Superficial Layers of the Olfactory Cortex Open
Seizure patterns identified in focal epilepsies caused by diverse etiologies are likely due to different pathogenic mechanisms. We describe here a novel, region-specific focal seizure pattern that mimics seizure activity observed in a subp…