Laura Vinnenberg
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View article: Exercise facilitates post-stroke recovery through mitigation of neuronal hyperexcitability via interleukin-10 signaling
Exercise facilitates post-stroke recovery through mitigation of neuronal hyperexcitability via interleukin-10 signaling Open
Physical exercise is an effective therapy for improving stroke recovery. However, the exact underlying molecular mechanisms of exercise-enhanced neuronal repair remain unclear. As exercise affects the immune system in healthy individuals, …
View article: TREK1 Channels Shape Spindle-Like Oscillations, Neuronal Activity, and Short-Term Synaptic Plasticity in Thalamocortical Circuits
TREK1 Channels Shape Spindle-Like Oscillations, Neuronal Activity, and Short-Term Synaptic Plasticity in Thalamocortical Circuits Open
Although TREK1 channels are widely expressed in several thalamic nuclei, the role of this K 2P family member in modulating thalamic cell excitability and physiological thalamocortical oscillatory activity is not well studied. Here we explo…
View article: Cytoskeletal disruption-induced calcium dysregulation drives cell death in anti-IgLON5 disease
Cytoskeletal disruption-induced calcium dysregulation drives cell death in anti-IgLON5 disease Open
View article: Visualization of K<sub>Ca</sub>3.1 Channels in Tumor Cells by Optimized Senicapoc-Bodipy Conjugates
Visualization of K<sub>Ca</sub>3.1 Channels in Tumor Cells by Optimized Senicapoc-Bodipy Conjugates Open
Upregulation of KCa3.1 channels was observed in highly aggressive tumor cells, such as non small cell lung cancer cells of the A549 line. In order to visualize KCa3.1 channels in these cells, novel fluorescent probes …
View article: The potassium channel K2P2.1 shapes the morphology and function of brain endothelial cells via actin network remodeling
The potassium channel K2P2.1 shapes the morphology and function of brain endothelial cells via actin network remodeling Open
K 2P 2.1 (gene: Kcnk2 ), a two-pore-domain potassium channel, regulates leukocyte transmigration across the blood-brain barrier by a yet unknown mechanism. We demonstrate that Kcnk2 −/− mouse brain microvascular endothelial cells (MBMECs) …
View article: Fluorescent Probes to Image the KCa3.1 Channel in Tumor Cells
Fluorescent Probes to Image the KCa3.1 Channel in Tumor Cells Open
Background/Objectives: The Ca2+-activated K+ channel KCa3.1 is not only involved in physiological processes such as immune reactions and control of vascular tone, but is highly expressed in various tumor entities. Thus, imaging of KCa3.1 c…
View article: Fluorescent Probes to Image the KCa3.1 Channel in Tumor Cells
Fluorescent Probes to Image the KCa3.1 Channel in Tumor Cells Open
The Ca2+ activated K+ channel KCa3.1 is not only involved in physiological processes such as immune reactions and control of vascular tone, but is highly expressed in various tumor entities. Thus, imaging of KCa3.1 channels comes into focu…
View article: Exploring P2x Receptor Activity: A Journey from Cellular Impact to Electrophysiological Profiling
Exploring P2x Receptor Activity: A Journey from Cellular Impact to Electrophysiological Profiling Open
View article: Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18
Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18 Open
HCN4 channels are considered to be a promising target for cardiac pathologies, epilepsy, and multiple sclerosis. However, there are no subtype‐selective HCN channel blockers available, and only a few compounds are reported to display subty…
View article: Effects of Axonal Demyelination, Inflammatory Cytokines and Divalent Cation Chelators on Thalamic HCN Channels and Oscillatory Bursting
Effects of Axonal Demyelination, Inflammatory Cytokines and Divalent Cation Chelators on Thalamic HCN Channels and Oscillatory Bursting Open
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that is characterized by the progressive loss of oligodendrocytes and myelin and is associated with thalamic dysfunction. Cuprizone (CPZ)-induced general demy…
View article: Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists
Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists Open
View article: Impact of Diverse Ion Channels on Regulatory T Cell Functions
Impact of Diverse Ion Channels on Regulatory T Cell Functions Open
The population of regulatory T cells (Tregs) is critical for immunological self-tolerance and homeostasis. Proper ion regulation contributes to Treg lineage identity, regulation, and effector function. Identified ion channels include Ca2+ …
View article: Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells
Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells Open
Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy with abnormal progenitor self-renewal and defective white blood cell differentiation. Its pathogenesis comprises subversion of transcriptional regulation, through mutat…
View article: Author response: Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells
Author response: Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Acute Myeloid Leukemia (AML) …