Liang Xie
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View article: 8276833 A quantitative algorithm to estimate endotoxin exposure for the spouses in the Agricultural Health Study
8276833 A quantitative algorithm to estimate endotoxin exposure for the spouses in the Agricultural Health Study Open
View article: Cryo-EM structures of Nipah virus polymerases and high-throughput biochemical RdRp assay development enable anti-NiV drug discovery
Cryo-EM structures of Nipah virus polymerases and high-throughput biochemical RdRp assay development enable anti-NiV drug discovery Open
The transcription and replication of Nipah virus (NiV) is driven by the large protein (L) and its essential co-factor phosphoprotein (P). L encodes all the viral enzymatic functions including RNA-dependent RNA polymerase (RdRp) activity wh…
View article: Author Correction: RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix
Author Correction: RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix Open
View article: The research progress on periodontitis by the National Natural Science Foundation of China
The research progress on periodontitis by the National Natural Science Foundation of China Open
Periodontitis has emerged as one of the most critical oral diseases, and research on this condition holds great importance for the advancement of stomatology. As the most authoritative national scientific research funding institution in Ch…
View article: Characterizing hub biomarkers for metabolic-induced endothelial dysfunction and unveiling their regulatory roles in EndMT through RNA sequencing and machine learning approaches
Characterizing hub biomarkers for metabolic-induced endothelial dysfunction and unveiling their regulatory roles in EndMT through RNA sequencing and machine learning approaches Open
Background Metabolic disorder and endothelial dysfunction (ED) are key events in the development and pathophysiology of atherosclerosis and are associated with an elevated risk of Cardiovascular disease (CVD). The pathophysiology remains i…
View article: MicroRNA-195-5p suppresses metastasis by targeting VEGFA in nasopharyngeal carcinoma
MicroRNA-195-5p suppresses metastasis by targeting VEGFA in nasopharyngeal carcinoma Open
Background MicroRNA (miRNA) plays an important role in nasopharyngeal carcinoma (NPC). We aimed to identify a microRNA that can help us understand the molecular mechanism and develop target therapy for NPC. Methods: MiRNA expression levels…
View article: Developing a machine learning model for accurate nucleoside hydrogels prediction based on descriptors
Developing a machine learning model for accurate nucleoside hydrogels prediction based on descriptors Open
Supramolecular hydrogels derived from nucleosides have been gaining significant attention in the biomedical field due to their unique properties and excellent biocompatibility. However, a major challenge in this field is that there is no m…
View article: Loss of PA28γ exacerbates imbalanced differentiation of bone marrow stromal cells during bone formation and bone healing in mice
Loss of PA28γ exacerbates imbalanced differentiation of bone marrow stromal cells during bone formation and bone healing in mice Open
Proteasome activator subunit 3 (PA28γ) is a member of the proteasome activator family, which mainly regulates the degradation and stability of proteins. Studies have shown that it plays crucial roles in lipid formation, stemness maintenanc…
View article: Late diagnosis of X‐linked hyper‐IgM syndrome presenting as community‐acquired <i>Pseudomonas aeruginosa</i> pneumonia‐related septic shock
Late diagnosis of X‐linked hyper‐IgM syndrome presenting as community‐acquired <i>Pseudomonas aeruginosa</i> pneumonia‐related septic shock Open
Pseudomonas aeruginosa, a gram-negative aerobic bacterium, is an uncommon but fatal causative pathogen for community-acquired pneumonia (CAP).1 X-linked hyper-IgM syndrome (XHIGM; HIGM1; OMIM:308230) is one type of inborn errors of immunit…
View article: Association between human herpes simplex virus and periodontitis: results from the continuous National Health and Nutrition Examination Survey 2009–2014
Association between human herpes simplex virus and periodontitis: results from the continuous National Health and Nutrition Examination Survey 2009–2014 Open
View article: Visible Light–Near-Infrared Photodetection on Cys-MoO3−x Nanoparticles for Photothermal Therapy against Papillary Thyroid Carcinoma
Visible Light–Near-Infrared Photodetection on Cys-MoO3−x Nanoparticles for Photothermal Therapy against Papillary Thyroid Carcinoma Open
The excellent performance of semiconductor nanocrystals as sensitizers for photothermal therapy (PTT) has attracted the attention of many researchers; however, they are hindered by limited bandwidth and complex synthesis. To overcome these…
View article: Identification of unique α4 chain structure and conserved antiangiogenic activity of <scp>α3NC1</scp> type <scp>IV</scp> collagen in zebrafish
Identification of unique α4 chain structure and conserved antiangiogenic activity of <span>α3NC1</span> type <span>IV</span> collagen in zebrafish Open
Background Type IV collagen is an abundant component of basement membranes in all multicellular species and is essential for the extracellular scaffold supporting tissue architecture and function. Lower organisms typically have two type IV…
View article: Genetic mapping and molecular mechanism behind color variation in the Asian vine snake
Genetic mapping and molecular mechanism behind color variation in the Asian vine snake Open
Background Reptiles exhibit a wide variety of skin colors, which serve essential roles in survival and reproduction. However, the molecular basis of these conspicuous colors remains unresolved. Results We investigate color morph-enriched A…
View article: Advancements of molecular imaging and radiomics in pancreatic carcinoma
Advancements of molecular imaging and radiomics in pancreatic carcinoma Open
Despite the recent progress of medical technology in the diagnosis and treatment of tumors, pancreatic carcinoma remains one of the most malignant tumors, with extremely poor prognosis partly due to the difficulty in early and accurate ima…
View article: The Protective Role of Interleukin 17A in Acinetobacter baumannii Pneumonia Is Associated with Candida albicans in the Airway
The Protective Role of Interleukin 17A in Acinetobacter baumannii Pneumonia Is Associated with Candida albicans in the Airway Open
Recent studies have found that the coexistence of fungi and bacteria in the airway may increase the risk of infection, contribute to the development of pneumonia, and increase the severity of disease. Interleukin 17A (IL-17A) plays importa…
View article: Additional file 2 of Genetic mapping and molecular mechanism behind color variation in the Asian vine snake
Additional file 2 of Genetic mapping and molecular mechanism behind color variation in the Asian vine snake Open
Additional file 2: Table S9. Significant SNPs in the chromosomal region of GWAS signals.
View article: Supplementary Materials of Large chromosomal inversion contributes to speciation in the treefrog
Supplementary Materials of Large chromosomal inversion contributes to speciation in the treefrog Open
FISH figures, calls records and figures and whole-genome NJ tree
View article: Multiomics Analysis of a DNAH5-Mutated PCD Organoid Model Revealed the Key Role of the TGF-β/BMP and Notch Pathways in Epithelial Differentiation and the Immune Response in DNAH5-Mutated Patients
Multiomics Analysis of a DNAH5-Mutated PCD Organoid Model Revealed the Key Role of the TGF-β/BMP and Notch Pathways in Epithelial Differentiation and the Immune Response in DNAH5-Mutated Patients Open
Dynein axonemal heavy chain 5 (DNAH5) is the most mutated gene in primary ciliary dyskinesia (PCD), leading to abnormal cilia ultrastructure and function. Few studies have revealed the genetic characteristics and pathogenetic mechanisms of…
View article: Dynamic alteration in SULmax predicts early pathological tumor response and short-term prognosis in non-small cell lung cancer treated with neoadjuvant immunochemotherapy
Dynamic alteration in SULmax predicts early pathological tumor response and short-term prognosis in non-small cell lung cancer treated with neoadjuvant immunochemotherapy Open
Introduction: Biomarkers predicting tumor response to neoadjuvant immunochemotherapy in non-small cell lung cancer (NSCLC) are still lacking despite great efforts. We aimed to assess the effectiveness of the immune PET Response Criteria in…
View article: m6A-binding protein IGF2BP1 promotes the malignant phenotypes of lung adenocarcinoma
m6A-binding protein IGF2BP1 promotes the malignant phenotypes of lung adenocarcinoma Open
Background Lung adenocarcinoma (LUAD), the most common type of lung cancer, poses a significant threat to the life of patients. N6-methyladenosine modification is the most abundant epigenetic modification and may play an important role in …
View article: Association between maternal smoke exposure and congenital heart defects from a case–control study in China
Association between maternal smoke exposure and congenital heart defects from a case–control study in China Open
View article: [Pulmonary Vascular Remodeling Characteristics of Pulmonary Arterial Hypertension Mouse Model Induced by Left Pneumonectomy and Jugular Vein Injection of Monocrotaline Pyrrole].
[Pulmonary Vascular Remodeling Characteristics of Pulmonary Arterial Hypertension Mouse Model Induced by Left Pneumonectomy and Jugular Vein Injection of Monocrotaline Pyrrole]. Open
Left pneumonectomy combined with jugular intravenous injection of MCTP could induce severe PAH formation in mouse. The model provides a good simulation of neointima formation, the characteristic pathological change of clinical severe PAH.
View article: Identification of unique α4 chain structure and conserved anti-angiogenic activity of α3NC1 type IV collagen in zebrafish
Identification of unique α4 chain structure and conserved anti-angiogenic activity of α3NC1 type IV collagen in zebrafish Open
Type IV collagen is an abundant component of basement membranes in all multicellular species and is essential for the extracellular scaffold supporting tissue architecture and function. Lower organisms typically have two type IV collagen g…
View article: Ataxia telangiectasia mutated: The potential negative regulator in platelet-derived growth factor-BB promoted proliferation of pulmonary arterial smooth muscle cells
Ataxia telangiectasia mutated: The potential negative regulator in platelet-derived growth factor-BB promoted proliferation of pulmonary arterial smooth muscle cells Open
Objective To study the role of ataxia telangiectasia mutated (ATM) in the platelet-derived growth factor (PDGF)-BB-induced proliferation of pulmonary arterial smooth muscle cells (PASMCs) through reactive oxygen species (ROS) formation. Me…
View article: Pathological Responses of the Primary Tumor and Locoregional Lymph Nodes After Neoadjuvant Immunochemotherapy in Esophageal Squamous Cell Cancer
Pathological Responses of the Primary Tumor and Locoregional Lymph Nodes After Neoadjuvant Immunochemotherapy in Esophageal Squamous Cell Cancer Open
We conclusively noted that most patients receiving NAIC were tumor good-responders, whereas only one-third of patients were nodal good-responders. Furthermore, we identified that treatment cycle number and baseline platelet counts were ind…
View article: Conversion Surgery Following Immunochemotherapy in Initially Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma—A Real-World Multicenter Study (RICE-Retro)
Conversion Surgery Following Immunochemotherapy in Initially Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma—A Real-World Multicenter Study (RICE-Retro) Open
Purpose The present study sets out to evaluate the feasibility, safety, and effectiveness of conversion surgery following induction immunochemotherapy for patients with initially unresectable locally advanced esophageal squamous cell carci…
View article: Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening
Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening Open
View article: Maternal serum CFHR4 protein as a potential non-invasive marker of ventricular septal defects in offspring: evidence from a comparative proteomics study
Maternal serum CFHR4 protein as a potential non-invasive marker of ventricular septal defects in offspring: evidence from a comparative proteomics study Open
Background Despite advances in diagnosis of congenital heart defects, there is no non-invasive biomarker clinically available for the early detection of fetal ventricular septal defects (VSD). Methods This study was to profile differential…
View article: Cell-Free DNA Promotes Inflammation in Patients With Oral Lichen Planus via the STING Pathway
Cell-Free DNA Promotes Inflammation in Patients With Oral Lichen Planus via the STING Pathway Open
Background Damaged and dead cells release cell-free DNA (cfDNA) that activates cyclic GMP–AMP (cGAMP) synthase (cGAS), which leads to the activation of stimulator of interferon genes (STING) via the second messenger cGAMP. STING promotes t…
View article: A novel prognostic model: which group of esophageal squamous cell carcinoma patients could benefit from adjuvant chemotherapy
A novel prognostic model: which group of esophageal squamous cell carcinoma patients could benefit from adjuvant chemotherapy Open
Differentiating high- and low-risk patient groups via a novel mathematical prediction model allows physicians to identify patients in need of adjuvant chemotherapy accurately.