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View article: Primary Cell Cultures in Neurobiology: Optimized Protocol for Culture of Mouse Fetal Hindbrain Neurons
Primary Cell Cultures in Neurobiology: Optimized Protocol for Culture of Mouse Fetal Hindbrain Neurons Open
Primary cultures of neural cells are important key tools for basic and translational neuroscience research. These primary cell cultures are classically generated from the rodent brain hippocampus or cortex and optimized for enrichment in n…
View article: Insights into the bioluminescence systems of three sea pens (Cnidaria: Anthozoa): from de novo transcriptome analyses to biochemical assays
Insights into the bioluminescence systems of three sea pens (Cnidaria: Anthozoa): from de novo transcriptome analyses to biochemical assays Open
Bioluminescence is the production of visible light by living organisms. It occurs through the oxidation of luciferin substrates catalysed by luciferase enzymes. Auxiliary proteins, such as fluorescent proteins and luciferin-binding protein…
View article: Ubiquitous MEIS transcription factors actuate lineage-specific transcription to establish cell fate
Ubiquitous MEIS transcription factors actuate lineage-specific transcription to establish cell fate Open
Control of gene expression is commonly mediated by distinct combinations of transcription factors (TFs). This cooperative action allows the integration of multiple biological signals at regulatory elements, resulting in highly specific gen…
View article: Homeodomain Involvement in Nuclear HOX Protein Homo- and Heterodimerization
Homeodomain Involvement in Nuclear HOX Protein Homo- and Heterodimerization Open
HOX genes play essential roles in patterning the anteroposterior axis of animal embryos and in the formation of various organs. In mammals, there are 39 HOX genes organized into four clusters (HOXA–D) located on different chromosomes. In r…
View article: A poly-histidine motif of HOXA1 is involved in regulatory interactions with cysteine-rich proteins
A poly-histidine motif of HOXA1 is involved in regulatory interactions with cysteine-rich proteins Open
View article: HOX Protein Activity Regulation by Cellular Localization
HOX Protein Activity Regulation by Cellular Localization Open
While the functions of HOX genes have been and remain extensively studied in distinct model organisms from flies to mice, the molecular biology of HOX proteins remains poorly documented. In particular, the mechanisms involved in regulating…
View article: Molecular Characterization of HOXA2 and HOXA3 Binding Properties
Molecular Characterization of HOXA2 and HOXA3 Binding Properties Open
The highly conserved HOX homeodomain (HD) transcription factors (TFs) establish the identity of different body parts along the antero–posterior axis of bilaterian animals. Segment diversification and the morphogenesis of different structur…
View article: HOXA1 Is an Antagonist of ERα in Breast Cancer
HOXA1 Is an Antagonist of ERα in Breast Cancer Open
Breast cancer is a heterogeneous disease and the leading cause of female cancer mortality worldwide. About 70% of breast cancers express ERα. HOX proteins are master regulators of embryo development which have emerged as being important pl…
View article: HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation
HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation Open
Gene expression programs determine cell fate in embryonic development and their dysregulation results in disease. Transcription factors (TFs) control gene expression by binding to enhancers, but how TFs select and activate their target enh…
View article: Uncovering tissue-specific binding features from differential deep learning
Uncovering tissue-specific binding features from differential deep learning Open
Transcription factors (TFs) can bind DNA in a cooperative manner, enabling a mutual increase in occupancy. Through this type of interaction, alternative binding sites can be preferentially bound in different tissues to regulate tissue-spec…
View article: HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation
HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation Open
Summary Gene expression programs determine cell fate in embryonic development and their dysregulation results in disease. Transcription factors (TFs) control gene expression by binding to enhancers, but how TFs select and activate their ta…
View article: Uncovering tissue-specific binding features from differential deep learning
Uncovering tissue-specific binding features from differential deep learning Open
Deep learning models of MEIS differential binding in mouse branchial arches, and MEF2D differential binding in three mouse tissues (cortical neurons, retina, myotubes). You can use the code in 'main' alone to train architectures described …
View article: Uncovering tissue-specific binding features from differential deep learning
Uncovering tissue-specific binding features from differential deep learning Open
Deep learning models of MEIS differential binding in mouse branchial arches, and MEF2D differential binding in three mouse tissues (cortical neurons, retina, myotubes). You can use the code in 'main' alone to train architectures described …
View article: HOXA2 activity regulation by cytoplasmic relocation, protein stabilization and post-translational modification
HOXA2 activity regulation by cytoplasmic relocation, protein stabilization and post-translational modification Open
View article: Uncovering tissue-specific binding features from differential deep learning
Uncovering tissue-specific binding features from differential deep learning Open
Deep learning models of MEIS differential binding in mouse branchial arches. Zips contain source code, datasets, and trained models. To replicate the results in the paper, download all files and unpack 'models' and 'data' into the root fol…
View article: Uncovering tissue-specific binding features from differential deep learning
Uncovering tissue-specific binding features from differential deep learning Open
Motivation Transcription factors (TFs) can bind DNA in a cooperative manner, enabling a mutual increase in occupancy. Through this type of interaction, alternative binding sites can be preferentially bound in different tissues to regulate …
View article: Uncovering tissue-specific binding features from differential deep learning
Uncovering tissue-specific binding features from differential deep learning Open
Deep learning models of MEIS differential binding in mouse branchial arches. Zips contain source code, datasets, and trained models. To replicate the results in the paper, download all files and unpack 'models' and 'data' into the root fol…
View article: Uncovering tissue-specific binding features from differential deep learning
Uncovering tissue-specific binding features from differential deep learning Open
Deep learning models of MEIS differential binding in mouse branchial arches. Zips contain source code, datasets, and trained models. To replicate the results in the paper, download all files and unpack 'models' and 'data' into the root fol…
View article: The O‐GlcNAc transferase <scp>OGT</scp> interacts with and post‐translationally modifies the transcription factor <scp>HOXA</scp>1
The O‐GlcNAc transferase <span>OGT</span> interacts with and post‐translationally modifies the transcription factor <span>HOXA</span>1 Open
HOXA 1 belongs to the HOX family of transcription factors which are key regulators of animal development. Little is known about the molecular pathways controlling HOXA 1. Recent data from our group revealed distinct partner proteins intera…
View article: Post-translational modifications of HOX proteins, an underestimated issue
Post-translational modifications of HOX proteins, an underestimated issue Open
Post-translational modifications (PTMs) are important determinants which contribute to modulating the turn-over, intracellular localisation, molecular interactions and activity of most eukaryotic proteins. Such modifications and their cons…
View article: A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree
A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree Open
Connection of the heart to the systemic circulation is a critical developmental event that requires selective preservation of embryonic vessels (aortic arches). However, why some aortic arches regress while others are incorporated into the…
View article: Author response: A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree
Author response: A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree Open
View article: Dynamic Pattern of HOXB9 Protein Localization during Oocyte Maturation and Early Embryonic Development in Mammals
Dynamic Pattern of HOXB9 Protein Localization during Oocyte Maturation and Early Embryonic Development in Mammals Open
Together, these results could suggest the existence of unsuspected functions for HOXB9 during early embryonic development in mammals.
View article: Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1
Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1 Open
The homeodomain transcription factor Hoxa2 interacts with the RING-finger type E3 ubiquitin ligase RCHY1 and induces its proteasomal degradation. In this work, we dissected this non-transcriptional activity of Hoxa2 at the molecular level.…
View article: KPC2 relocalizes HOXA2 to the cytoplasm and decreases its transcriptional activity
KPC2 relocalizes HOXA2 to the cytoplasm and decreases its transcriptional activity Open