Laure C. Bouchez
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View article: Molecular characterization of chronic cutaneous wounds reveals subregion‐ and wound type‐specific differential gene expression
Molecular characterization of chronic cutaneous wounds reveals subregion‐ and wound type‐specific differential gene expression Open
A limited understanding of the pathology underlying chronic wounds has hindered the development of effective diagnostic markers and pharmaceutical interventions. This study aimed to elucidate the molecular composition of various common chr…
View article: Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma
Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma Open
Lysosomal sequestration of anti-cancer compounds reduces drug availability at intracellular target sites, thereby limiting drug-sensitivity and inducing chemoresistance. For hepatocellular carcinoma (HCC), sorafenib (SF) is the first line …
View article: Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin
Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin Open
Selective and specific inhibitors of Plasmodium falciparum lysyl‐tRNA synthetase represent promising therapeutic antimalarial avenues. Cladosporin was identified as a potent P. falciparum lysyl‐tRNA synthetase inhibitor, with an activity a…
View article: Hypoxia-Activated, Small-Molecule-Induced Gene Expression
Hypoxia-Activated, Small-Molecule-Induced Gene Expression Open
Hypoxia, a condition of reduced oxygen, occurs in a wide variety of biological contexts, including solid tumors and bacterial biofilms, which are relevant to human health. Consequently, the development of chemical tools to study hypoxia is…
View article: Hypoxia-Activated Small Molecule-Induced Gene Expression
Hypoxia-Activated Small Molecule-Induced Gene Expression Open
Hypoxia, conditions of reduced oxygen, occur in a wide variety of biological contexts, including solid tumours and bacterial biofilms, which are relevant to human health. Consequently, the development of chemical tools to study hypoxia is …
View article: Hypoxia-Activated Small Molecule-Induced Gene Expression
Hypoxia-Activated Small Molecule-Induced Gene Expression Open
Hypoxia, conditions of reduced oxygen, occur in a wide variety of biological contexts, including solid tumours and bacterial biofilms, which are relevant to human health. Consequently, the development of chemical tools to study hypoxia is …
View article: Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology
Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology Open
Oral and intestinal mucositis is a debilitating side effect of radiation treatment. A mouse model of radiation-induced mucositis leads to weight loss and tissue damage, reflecting the human ailment as it responds to keratinocyte growth fac…