Laureen D. Hachem
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View article: Pharmacological Therapies for Spinal Cord Injury
Pharmacological Therapies for Spinal Cord Injury Open
View article: Clinical, Molecular and Genetic Features of Spinal Meningiomas
Clinical, Molecular and Genetic Features of Spinal Meningiomas Open
Spinal meningiomas comprise 25-46% of all primary spinal tumors. While the majority are benign and slow growing, when left untreated, they can result in significant neurological decline. Emerging clinical, imaging, and molecular data has b…
View article: An Update of a Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Role and Timing of Decompressive Surgery
An Update of a Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Role and Timing of Decompressive Surgery Open
Study Design Clinical practice guideline development. Objectives Acute spinal cord injury (SCI) can result in devastating motor, sensory, and autonomic impairment; loss of independence; and reduced quality of life. Preclinical evidence sug…
View article: Timing of Decompressive Surgery in Patients With Acute Spinal Cord Injury: Systematic Review Update
Timing of Decompressive Surgery in Patients With Acute Spinal Cord Injury: Systematic Review Update Open
Study design Systematic review and meta-analysis. Objective Surgical decompression is a cornerstone in the management of patients with traumatic spinal cord injury (SCI); however, the influence of the timing of surgery on neurological reco…
Canadian Spine SocietyCPSS-1. Abstract ID 108. Radiographic reporting in adolescent idiopathic scoliosis: Is there a discrepancy between radiologists’ reports and surgeons’ assessments?CPSS-2. Abstract ID 21. Pediatric posterior spinal deformity correction: 30-day postoperative infection rate and risk factorsCPSS-3. Abstract ID 17. “Ultra-low dose” computed tomography without sedation is feasible and should be considered as part of the preoperative optimization pathway in paediatric patients with neuromuscular scoliosisCPSS-4. Abstract ID 20. SeeSpine: a novel surface topography smartphone application for monitoring curve progression in adolescent idiopathic scoliosisCPSS-5. Abstract ID 78. Pilot study: a machine learning algorithm for the detection of adolescent idiopathic scoliosis from images taken with modern smartphone technologyCPSS-6. Abstract ID 101. Preoperative parameters influencing vertebral body tethering outcomes: patient characteristics play an important role in determining the outcomes at 2 years after surgeryCPSS-7. Abstract ID 63. Preoperative bending radiographs are the best predictor of scoliosis correction on the first erect radiograph in vertebral body tethering: a single-centre retrospective studyCPSS-8. Abstract ID 18. Adverse events after zoledronate infusion in medically complex patients with neuromuscular scoliosisCPSS-9. Abstract ID 5. Sequential rod rolling for surgical correction of Lenke type 2 adolescent idiopathic scoliosis: a 3D analysisCPSS-10. Abstract ID 123. A comparative study of protocols for spinal casting as a surgical delay strategy in severe early-onset scoliosisA-11. Abstract ID 50. Does the type of pelvic fixation affect pelvic incidence after adult spinal deformity surgery? A retrospective analysisA-12. Abstract ID 51. How does pelvic fixation affect the compensatory mechanisms after adult spinal deformity surgery? A retrospective analysisA-13. Abstract ID 44. Development of a biomechanical model to identify risk factors in sagittal alignment contributing to proximal junctional kyphosisA-14. Abstract ID 32. Biomechanical characterization of semirigid constructs and the potential effect on proximal junctional kyphosisA-15. Abstract ID 65. Early adjacent disc characteristics are not associated with reoperation in short-segment lumbar fusionsA-16. Abstract ID 39. Concurrent validation of a novel inertial measurement unit–based method to evaluate spinal motion in clinical settingsA-17. Abstract ID 68. Distal lordosis is associated with reoperation for adjacent segment disease in patients with degenerative lumbar fusionA-18. Abstract ID 69. Automatic extraction of spinopelvic parameters using artificial intelligence methods and a review on the effects of spine stiffness, spinal fusion and spinopelvic parameters on lower limb motion and total hip arthroplasty outcomesA-19. Abstract ID 38. Gender differences in fusion rates in the treatment of degenerative lumbar spondylolisthesis: analysis from the CSORN prospective degenerative lumbar spondylolisthesis studyA-20. Abstract ID 29. L3–4 hyperlordosis after a reduction in lower lumbar lordosis with L4–L5 fusion surgery is common in patients requiring L3–4 revision surgery for adjacent segment diseaseB-21. Abstract ID 40. Predictors of dynamic instability in the decision to fuse in degenerative lumbar spondylolisthesis: results from the Canadian Spine Outcomes and Research Network prospective degenerative lumbar spondylolisthesisstudyB-22. Abstract ID 49. Impact of preoperative insomnia on poor postoperative pain control after elective spine surgery and the Modified Calgary Postoperative Pain After Spine Surgery scoreB-23. Abstract ID 115. Influence of high pelvic incidence on operative difficulty in patients treated surgically for degenerative lumbar spondylolisthesisB-24. Abstract ID 45. Reoperation rates for adjacent segment disease in degenerative lumbar fusion surgery: a comparison between minimally invasive versus open surgical approachesB-25. Abstract ID 118. Assessment of changes in opioid utilization 1 year after elective spine surgery: a Canadian Spine Outcomes and Research Network studyB-26. Abstract ID 93. Preoperative neuroleptic and opioid use effects on postoperative pain and disability after spinal surgery for lumbar radiculopathyB-27. Abstract ID 52. The importance of lower extremity compensation mechanisms in lumbar degenerative pathology: a retrospective analysisB-28. Abstract ID 107. Persistent poor sleep is associated with worse pain and quality of life in patients with degenerative thoracolumbar conditions undergoing surgery: a retrospective cohort studyB-29. Abstract ID 126. Opioid use in low back pain is associated with increased utilization of health care services and likelihood of work absenteeismB-30. Abstract ID 53. Wait times for degenerative lumbar spine consultation and surgery: a repeated cross-sectional analysis of the Canadian Spine Outcomes and Research NetworkC-31. Abstract ID 33. Pati Open
View article: A digital bridge to reverse paralysis
A digital bridge to reverse paralysis Open
View article: Neuroplasticity and regeneration after spinal cord injury
Neuroplasticity and regeneration after spinal cord injury Open
Spinal cord injury (SCI) is a debilitating condition with significant personal, societal, and economic burden. The highest proportion of traumatic injuries occur at the cervical level, which results in severe sensorimotor and autonomic def…
View article: Excitotoxic glutamate levels drive spinal cord ependymal stem cell proliferation and fate specification through CP-AMPAR signaling
Excitotoxic glutamate levels drive spinal cord ependymal stem cell proliferation and fate specification through CP-AMPAR signaling Open
The adult spinal cord contains a population of ependymal-derived neural stem/progenitor cells (epNSPCs) that are normally quiescent, but are activated to proliferate, differentiate, and migrate after spinal cord injury. The mechanisms that…
View article: A Practical Classification System for Acute Cervical Spinal Cord Injury Based on a Three-Phased Modified Delphi Process From the AOSpine Spinal Cord Injury Knowledge Forum
A Practical Classification System for Acute Cervical Spinal Cord Injury Based on a Three-Phased Modified Delphi Process From the AOSpine Spinal Cord Injury Knowledge Forum Open
Study Design A modified Delphi study. Objective To assess current practice patterns in the management of cervical spinal cord injury (SCI) and develop a simplified, practical classification system which offers ease of use in the acute sett…
View article: A deep learning model to classify neoplastic state and tissue origin from transcriptomic data
A deep learning model to classify neoplastic state and tissue origin from transcriptomic data Open
Application of deep learning methods to transcriptomic data has the potential to enhance the accuracy and efficiency of tissue classification and cell state identification. Herein, we developed a multitask deep learning model for tissue cl…
View article: Management of Diffuse Low-Grade Glioma: The Renaissance of Robust Evidence
Management of Diffuse Low-Grade Glioma: The Renaissance of Robust Evidence Open
The surgical management of diffuse low-grade gliomas (DLGGs) has undergone a paradigm shift toward striving for maximal safe resection when feasible. While extensive observational data supports this transition, unbiased evidence in the for…
View article: Ethical issues in geriatric cranial neurosurgery
Ethical issues in geriatric cranial neurosurgery Open
The global demographic shift to an older population has led to the emergence of the new field of geriatric neurosurgery. Beyond the complexities of disease states and multimorbidity, advanced age brings with it intricate ethical issues per…
Canadian Spine SocietyPresentation CPSS1: Spinal insufficiency fracture in the geriatric pediatric spinePresentation CPSS2: The clinical significance of tether breakages in anterior vertebral body growth modulation: a 2-year postoperative analysisPresentation CPSS3: Anterior vertebral body growth modulation for idiopathic scoliosis: early, mid-term and late complicationsPresentation CPSS4: Ovine model of congenital chest wall and spine deformity with alterations of respiratory mechanics: follow-up from birth to 3 monthsPresentation CPSS5: Test–retest reliability and minimum detectable change of the English translation of the Italian Spine Youth Quality of Life questionnaire in adolescents with idiopathic scoliosisPresentation B1. Abstract 31: Incidence of delayed spinal cord injury in pediatric spine deformity surgery seems to be higher than previously assumedPresentation B2. Abstract 155: What is the optimal surgical method for achieving successful symptom relief in pediatric high-grade spondylolisthesis?Presentation B3. Abstract 47: Vertebral body tethering: Truly motion preserving or rather limiting?Presentation B4. Abstract 180: Fusion rates in pediatric patients after posterior cervical spine instrumentationPresentation B5. Abstract 102: Effects of 8 years of growth hormone treatment on the onset and progression of scoliosis in children with Prader–Willi syndromePresentation B6. Abstract 144: Klippel–Feil syndrome: clinical phenotypes associated with surgical treatmentPresentation B7. Abstract 123: Anterior release for idiopathic scoliosis: Is it necessary for curve correction?Presentation B8. Abstract 62: Severe scoliosis: Do we know a better way? A retrospective comparative studyPresentation B9. Abstract 21: Intraoperative skull femoral traction in adolescent idiopathic scoliosis: the correlation of traction with side-bending radiographsPresentation B10. Abstract 147: What is the effect of intraoperative halo-femoral traction on correction of adolescent idiopathic scoliosis?Presentation B11. Abstract 174: Extreme long-term outcome of surgically versus non-surgically treated patients with adolescent idiopathic scoliosisPresentation B12. Abstract 172: The influence of multilevel spinal deformity surgery on the clinical outcome in the elderly: a prospective, observational, multicentre studyPresentation B13. Abstract 49: Demographics of a prospective evaluation of elderly deformity surgery: a prospective international observational multicentre studyPresentation B14. Abstract 119: Timing of conversion to cervical malalignment and proximal junctional kyphosis following surgical correction of adult spinal deformityPresentation B15. Abstract 44: Prioritization of realignment associated with superior clinical outcomes for surgical cervical deformity patientsPresentation B16. Abstract 50: Outcome of multilevel spinal deformity surgery in patients over 60 years of age: a multicentre international prospective studyPresentation B17. Abstract 122: A simpler, modified frailty index weighted by complication occurrence correlates to pain and disability for adult spinal deformity patientsPresentation B18. Abstract 75: Change in Oswestry Disability Index at 24 months following multilevel spinal deformity surgery in patients over 60 years of age: a multicentre international prospective studyPresentation C19. Abstract 19: A prospective cohort study evaluating trends in the surgical treatment of degenerative spondylolisthesis in Canada and the utility of a novel surgical decision aidPresentation C20. Abstract 154: Decompression compared with decompression and fusion for degenerative lumbar spondylolisthesis: a Canadian Spine Outcomes and Research Network (CSORN) studyPresentation C21. Abstract ID 77: Lumbar degenerative spondylolisthesis: factors impacting decision to fusePresentation C22. Abstract 27: Patient-reported outcomes following surgery for lumbar disc herniation: comparison of a universal and multitier health care systemPresentation C23. Abstract 151: Do patients with recurrent lumbar disc herniations fair worse with discectomy than primary operations? A retrospective analysis from the Canadian Spine Outcomes and Research NetworkPresentation C24. Abstract 136: A province-wide assessment of the appropriateness of lumbar spine MRIPresentation D25. Abstract 32: Surgical site infection reduction — a 10-year quality improvement journeyPresentation D26. Abstract 34: The impact of frailty on patient-reported outcome measures following elective thoraco-lumbar spine surgeryPresentation D27. Abstract 8: Moving toward better health: exercise practice is associated with improved outcomes after spine surgeryPresentation D28. Abstract 33: Preoperative decolonization does not adversely affect the microbiologic spectrum of spine surgical site infectionPresentation D29. Abstract 61: Feedback: reducing after-hours spine cases using an encrypted messaging systemPresentation D30. Abstract 177: Complex spine surgery is safe and effe Open
View article: The Cost-Effectiveness of 5-ALA in High-Grade Glioma Surgery: A Quality-Based Systematic Review
The Cost-Effectiveness of 5-ALA in High-Grade Glioma Surgery: A Quality-Based Systematic Review Open
Background: High-grade gliomas (HGGs) are aggressive tumors that inevitably recur due to their diffusely infiltrative nature. Intraoperative adjuncts such as 5-aminolevulinic acid (5-ALA) have shown promise in increasing extent of resectio…
View article: Assessment and treatment of childhood epilepsy in Haiti
Assessment and treatment of childhood epilepsy in Haiti Open
Objective The global burden of pediatric epilepsy is disproportionately concentrated in low‐ and middle‐income countries (LMICs). However, little is known about the effectiveness of current treatment programs in this setting. We present th…
View article: Unlocking the paradoxical endogenous stem cell response after spinal cord injury
Unlocking the paradoxical endogenous stem cell response after spinal cord injury Open
Nearly a century ago, the concept of the secondary injury in spinal cord trauma was first proposed to explain the complex cascade of molecular and cellular events leading to widespread neuronal and glial cell death after trauma. In recent …
View article: Predicting Outcomes After Surgical Decompression for Mild Degenerative Cervical Myelopathy: Moving Beyond the mJOA to Identify Surgical Candidates
Predicting Outcomes After Surgical Decompression for Mild Degenerative Cervical Myelopathy: Moving Beyond the mJOA to Identify Surgical Candidates Open
BACKGROUND Patients with mild degenerative cervical myelopathy (DCM) represent a heterogeneous population, and indications for surgical decompression remain controversial. OBJECTIVE To dissociate patient phenotypes within the broader popul…
View article: Invasive Neuromodulation for the Treatment of Pediatric Epilepsy
Invasive Neuromodulation for the Treatment of Pediatric Epilepsy Open
View article: The vagus afferent network: emerging role in translational connectomics
The vagus afferent network: emerging role in translational connectomics Open
Vagus nerve stimulation (VNS) is increasingly considered for the treatment of intractable epilepsy and holds potential for the management of a variety of neuropsychiatric conditions. The emergence of the field of connectomics and the intro…
View article: MGMT promoter methylation status testing to guide therapy for glioblastoma: refining the approach based on emerging evidence and current challenges
MGMT promoter methylation status testing to guide therapy for glioblastoma: refining the approach based on emerging evidence and current challenges Open
Glioblastoma (GBM) is the most common primary malignant brain tumor, with a universally poor prognosis. The emergence of molecular biomarkers has had a significant impact on histological typing and diagnosis, as well as predicting patient …
View article: 2018 Canadian Spine Society Abstracts
2018 Canadian Spine Society Abstracts Open
# Experiences in implementing the EOS radiographic system and SterEOS three-dimensional module {#article-title-2} The American Academy of Orthopaedic Surgeons, Scoliosis Research Society, Pediatric Orthopaedic Society of North America and …
View article: CMET-05. HEALTH-ECONOMIC ANALYSES OF RADIOTHERAPY FOR PATIENTS WITH BRAIN METASTASES: CAN ECONOMICS GUIDE THE ESTABLISHMENT OF PATIENT CARE PATHWAYS?
CMET-05. HEALTH-ECONOMIC ANALYSES OF RADIOTHERAPY FOR PATIENTS WITH BRAIN METASTASES: CAN ECONOMICS GUIDE THE ESTABLISHMENT OF PATIENT CARE PATHWAYS? Open
INTRODUCTION: Treatment options for brain metastases include whole-brain radiation therapy (WBRT), stereotaxic radiosurgery (SRS), and surgical resection followed by adjuvant therapy. Although SRS provides similar survival benefits and pos…
View article: SURG-22. QUALITY BASED ASSESSMENT OF THE COST-EFFECTIVENESS OF 5-ALA IN HIGH GRADE GLIOMA SURGERY: A SYSTEMATIC REVIEW
SURG-22. QUALITY BASED ASSESSMENT OF THE COST-EFFECTIVENESS OF 5-ALA IN HIGH GRADE GLIOMA SURGERY: A SYSTEMATIC REVIEW Open
BACKGROUND: High grade gliomas (HGG) are the most common primary malignant brain tumors in adults. While the infiltrative nature of HGG makes safe maximal resections challenging, studies on the use of adjuncts such as 5-ALA have shown much…
View article: Assessment and management of acute spinal cord injury: From point of injury to rehabilitation
Assessment and management of acute spinal cord injury: From point of injury to rehabilitation Open
Pharmacologic treatments, cell-based therapies, and other technology-driven interventions will likely play a combinatorial role in the evolving management of SCI as the field continues to evolve.
View article: Citation classics in neuro-oncology: assessment of historical trends and scientific progress
Citation classics in neuro-oncology: assessment of historical trends and scientific progress Open
The majority of citation classics in neuro-oncology are related to gliomas and pertain to tumor pathogenesis and treatment. The rise in citation classics in recent years investigating tumor biology, new treatment agents, and chemotherapeut…
View article: Postoperative surgical-site hemorrhage after kidney transplantation: incidence, risk factors, and outcomes
Postoperative surgical-site hemorrhage after kidney transplantation: incidence, risk factors, and outcomes Open
Studies investigating the incidence, risk factors, and outcomes of surgical-site hemorrhage after kidney transplantation are limited. Patients who underwent a kidney transplant from 1 January 2000 to 30 September 2012 (followed until 31 De…
View article: The role of 5‐aminolevulinic acid in enhancing surgery for high‐grade glioma, its current boundaries, and future perspectives: A systematic review
The role of 5‐aminolevulinic acid in enhancing surgery for high‐grade glioma, its current boundaries, and future perspectives: A systematic review Open
5‐Aminolevulinic acid (5‐ALA) has been approved as an intraoperative adjunct in glioma surgery in Europe, but not North America. A systematic review was conducted to assess the evidence regarding 5‐ALA as a surgical adjunct. The MEDLINE, E…
View article: Experience with Canada’s First Policy on Concussion Education and Management in Schools
Experience with Canada’s First Policy on Concussion Education and Management in Schools Open
Background: In response to the rising incidence of concussions among children and adolescents, the province of Ontario recently introduced the Ontario Policy/Program Memorandum on Concussions (PPM No. 158) requiring school boards to develo…
View article: Effect of BDNF and Other Potential Survival Factors in Models of <i>In Vitro</i> Oxidative Stress on Adult Spinal Cord–Derived Neural Stem/Progenitor Cells
Effect of BDNF and Other Potential Survival Factors in Models of <i>In Vitro</i> Oxidative Stress on Adult Spinal Cord–Derived Neural Stem/Progenitor Cells Open
Transplantation of neural stem/progenitor cells (NSPCs) is a promising strategy in spinal cord injury (SCI). However, poor survival of transplanted stem cells remains a major limitation of this therapy due to the hostile environment of the…