Laurel A. Thur
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View article: Old Pathogens–New Patient Types: Infections in a CAR T‐Cell Recipient. Could It Get Any More Complicated?
Old Pathogens–New Patient Types: Infections in a CAR T‐Cell Recipient. Could It Get Any More Complicated? Open
The case discussed involves a 41‐year‐old Italian man who was a candidate for chimeric antigen receptor T‐cell therapy (CAR‐T) for mediastinal diffuse large B‐cell lymphoma. His CAR‐T treatment was postponed several times due to prolonged …
View article: Real-world outcomes of infections following tisagenlecleucel in patients with B-cell ALL: a CIBMTR analysis
Real-world outcomes of infections following tisagenlecleucel in patients with B-cell ALL: a CIBMTR analysis Open
Tisagenlecleucel (tisa-cel) is a CD19-directed chimeric antigen receptor T-cell therapy for relapsed/refractory precursor B-cell acute lymphoblastic leukemia (R/R B-ALL). We report infectious complications for 100 days (D100) following tis…
View article: Infection after CD19 chimeric antigen receptor T-cell therapy for large B-cell lymphoma: real-world analysis from CIBMTR
Infection after CD19 chimeric antigen receptor T-cell therapy for large B-cell lymphoma: real-world analysis from CIBMTR Open
Infection is increasingly recognized as a significant cause of morbidity and mortality in patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL) receiving CD19 chimeric antigen receptor (CAR) T-cell therapy. The current study…
View article: Delayed T-cell recovery after hematopoietic cell transplantation is associated with decreased overall survival in adults
Delayed T-cell recovery after hematopoietic cell transplantation is associated with decreased overall survival in adults Open
Allogeneic hematopoietic cell transplantation (allo-HCT) can provide curative treatment for hematologic malignancies but is associated with prolonged lymphopenia that may contribute to an increased risk of infection and relapse, resulting …
View article: The impact of CMV reactivation on mortality after chimeric antigen receptor T-cell therapy
The impact of CMV reactivation on mortality after chimeric antigen receptor T-cell therapy Open
View article: Long-term outcomes and quality of life with treosulfan-based conditioning in hematological malignancies
Long-term outcomes and quality of life with treosulfan-based conditioning in hematological malignancies Open
View article: Development and validation of predictive models of early immune effector cell–associated hematotoxicity
Development and validation of predictive models of early immune effector cell–associated hematotoxicity Open
Immune effector cell–associated hematotoxicity (ICAHT) is associated with morbidity and mortality after chimeric antigen receptor (CAR) T-cell therapy. To date, the factors associated with ICAHT are poorly characterized, and there is no va…
View article: Acute kidney injury and chronic kidney disease in umbilical cord blood transplant recipients
Acute kidney injury and chronic kidney disease in umbilical cord blood transplant recipients Open
Introduction Acute kidney injury (AKI) is a frequent early complication post hematopoietic stem cell transplant (HSCT), associated with high morbidity and mortality. Cord blood transplant (CBT) recipients are potentially exposed to more ne…
View article: Infusion of Non-HLA-Matched Off-the-Shelf Ex Vivo Expanded Cord Blood Progenitors in Patients Undergoing Cord Blood Transplantation: Result of a Phase II Clinical Trial
Infusion of Non-HLA-Matched Off-the-Shelf Ex Vivo Expanded Cord Blood Progenitors in Patients Undergoing Cord Blood Transplantation: Result of a Phase II Clinical Trial Open
Recipients of myeloablative cord blood transplants (CBT) are known to experience delayed hematopoietic recovery and an increased risk of transplant related mortality (TRM). We developed methods for ex vivo expansion and cryopreservation of…
View article: Delayed-onset cytomegalovirus infection is frequent after discontinuing letermovir in cord blood transplant recipients
Delayed-onset cytomegalovirus infection is frequent after discontinuing letermovir in cord blood transplant recipients Open
Cytomegalovirus (CMV)-seropositive umbilical cord blood transplantation (CBT) recipients have a high incidence of CMV-associated complications. There are limited data regarding the efficacy of letermovir for preventing clinically significa…
View article: Shared inflammatory pathways and therapeutic strategies in COVID-19 and cancer immunotherapy
Shared inflammatory pathways and therapeutic strategies in COVID-19 and cancer immunotherapy Open
COVID-19, the syndrome caused by the infection with SARS-CoV-2 coronavirus, is characterized, in its severe form, by interstitial diffuse pneumonitis and acute respiratory distress syndrome (ARDS). ARDS and systemic manifestations of COVID…
View article: Pain Management in Childhood Leukemia: Diagnosis and Available Analgesic Treatments
Pain Management in Childhood Leukemia: Diagnosis and Available Analgesic Treatments Open
Pain is one of the most common symptoms in children suffering from leukemia, who are often misdiagnosed with other childhood painful diseases such as juvenile idiopathic arthritis. Corticosteroid-induced osteonecrosis (ON) and vincristine-…
View article: Cord blood maternal microchimerism following unrelated cord blood transplantation
Cord blood maternal microchimerism following unrelated cord blood transplantation Open
View article: Impact of T Cell Repertoire Diversity on Mortality Following Cord Blood Transplantation
Impact of T Cell Repertoire Diversity on Mortality Following Cord Blood Transplantation Open
Using a fast high-throughput TCR sequencing assay we have demonstrated that high TCR diversity is associated with better patient outcomes following CBT. Importantly, this assay is easily performed on posttransplant PB samples, even as earl…
View article: Treosulfan-based conditioning is feasible and effective for cord blood recipients: a phase 2 multicenter study
Treosulfan-based conditioning is feasible and effective for cord blood recipients: a phase 2 multicenter study Open
Although the use of treosulfan (TREO) in conventional donor hematopoietic cell transplantation (HCT) has been extensively evaluated, its use in cord blood transplantation (CBT) for hematologic malignancies has not been reported. Between Ma…
View article: Tetrahydrobiopterin Restores Microvascular Dysfunction in Young Adult Binge Drinkers
Tetrahydrobiopterin Restores Microvascular Dysfunction in Young Adult Binge Drinkers Open
Background Repeated binge drinking is associated with reduced microvascular function. However, microvascular responses to pathophysiological stimulus such as high pressure as well as potential mechanisms that underlie binge‐induced microva…
View article: The effects of repeated binge drinking on arterial stiffness and urinary norepinephrine levels in young adults
The effects of repeated binge drinking on arterial stiffness and urinary norepinephrine levels in young adults Open
Our findings suggest that repeated exposure to alcohol, regardless of drinking pattern, may increase aortic arterial stiffness in healthy young adults. In addition, sympathetic activation, reflected by increased 24-h urinary norepinephrine…