Laurel Marsh
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View article: Safety and utility of magnetic resonance imaging of patients with external fixators: a systematic review
Safety and utility of magnetic resonance imaging of patients with external fixators: a systematic review Open
Objectives: To systematically review the literature on all reports of magnetic resonance imaging (MRI) use in patients with external fixators and evaluate for adverse events. Data Sources: MEDLINE, Embase, and Cochrane were searched for En…
View article: Modeling Hemodynamic Effects of the Closure Procedure of Carotid Artery Endarterectomy
Modeling Hemodynamic Effects of the Closure Procedure of Carotid Artery Endarterectomy Open
Currently, it is unclear why some patients experience restenosis after carotid endarterectomy (CEA) and whether the closing procedure is linked to greater rates of restenosis. Here, the morphology and hemodynamics are compared for the caro…
View article: To patch or not to patch: is that the real question? The role of hemodynamics in carotid endarterectomy. Illustrative cases
To patch or not to patch: is that the real question? The role of hemodynamics in carotid endarterectomy. Illustrative cases Open
BACKGROUND The utilizationof patches in carotid endarterectomy (CEA) for carotid artery stenosis remains controversial, with conflicting evidence regarding postoperative outcomes. This report accentuates this discourse with two selected re…
View article: Anterior Knee Pain and Knee Functional Scores Following Common Approaches to Tibial Shaft Fractures
Anterior Knee Pain and Knee Functional Scores Following Common Approaches to Tibial Shaft Fractures Open
Background: Tibial shaft fractures are common, causing substantial morbidity. Intramedullary nailing offers advantages but often leads to anterior knee pain and functional issues. Methods: Following Preferred Reporting Items for Systematic…
View article: Influence of Vessel Geometry, Flow Conditions, and Thrombin Concentration on Fibrin Accumulation and Cerebral Aneurysm Occlusion After Flow Diversion
Influence of Vessel Geometry, Flow Conditions, and Thrombin Concentration on Fibrin Accumulation and Cerebral Aneurysm Occlusion After Flow Diversion Open
As the number of cerebral aneurysms treated with flow diverters continues to increase, it is important to understand what factors influence not only thrombus formation within the aneurysm cavity but also fibrin accumulation across the devi…
View article: Modeling Fibrin Accumulation on Flow‐Diverting Devices for Intracranial Aneurysms
Modeling Fibrin Accumulation on Flow‐Diverting Devices for Intracranial Aneurysms Open
The mechanisms leading to aneurysm occlusion after treatment with flow‐diverting devices are not fully understood. Flow modification induces thrombus formation within the aneurysm cavity, but fibrin can simultaneously accumulate and cover …
View article: Computational Flow Diverter Implantation—A Comparative Study on Pre-Interventional Simulation and Post-Interventional Device Positioning for a Novel Blood Flow Modulator
Computational Flow Diverter Implantation—A Comparative Study on Pre-Interventional Simulation and Post-Interventional Device Positioning for a Novel Blood Flow Modulator Open
Due to their effect on aneurysm hemodynamics, flow diverters (FD) have become a routine endovascular therapy for intracranial aneurysms. Since over- and undersizing affect the device’s hemodynamic abilities, selecting the correct device di…
View article: Fusiform versus Saccular Intracranial Aneurysms—Hemodynamic Evaluation of the Pre-Aneurysmal, Pathological, and Post-Interventional State
Fusiform versus Saccular Intracranial Aneurysms—Hemodynamic Evaluation of the Pre-Aneurysmal, Pathological, and Post-Interventional State Open
Minimally-invasive therapies are well-established treatment methods for saccular intracranial aneurysms (SIAs). Knowledge concerning fusiform IAs (FIAs) is low, due to their wide and alternating lumen and their infrequent occurrence. Howev…
View article: Standardized viscosity as a source of error in computational fluid dynamic simulations of cerebral aneurysms
Standardized viscosity as a source of error in computational fluid dynamic simulations of cerebral aneurysms Open
Background Computational fluid dynamics (CFD) simulations are a powerful tool for studying cerebral aneurysms, capable of evaluating hemodynamics in a way that is infeasible with imaging alone. However, the difficulty of incorporating pati…
View article: P-016 Lagrangian trajectory simulations with synchrotron microtomography improves hemodynamic analysis of intracranial aneurysms treated with flow diverting stents
P-016 Lagrangian trajectory simulations with synchrotron microtomography improves hemodynamic analysis of intracranial aneurysms treated with flow diverting stents Open
Background Successful treatment of cerebral aneurysms with flow diverting stents (FDS) depends upon altering biomechanical forces to precipitate stable thrombus formation. Computational fluid dynamics (CFD) simulations can model such force…
View article: O-071 Estimation of optimal coil packing density using lagrangian particle tracking
O-071 Estimation of optimal coil packing density using lagrangian particle tracking Open
Background Aneurysm coil packing density has been studied as a surrogate for treatment outcome, but clinical results are conflicting. Previous work applying computational fluid dynamics simulations to coil embolization of cerebral aneurysm…
View article: Improving Computational Fluid Dynamics Simulations of Coiled Aneurysms Using Finite Element Modeling
Improving Computational Fluid Dynamics Simulations of Coiled Aneurysms Using Finite Element Modeling Open
Cerebral aneurysms are a serious clinical challenge, with ∼half resulting in death or disability. Treatment via endovascular coiling significantly reduces the chances of rupture, but the technique has failure rates between 25-40%. This pre…
View article: Modeling the Mechanical Microenvironment of Coiled Cerebral Aneurysms
Modeling the Mechanical Microenvironment of Coiled Cerebral Aneurysms Open
Successful occlusion of cerebral aneurysms using coil embolization is contingent upon stable thrombus formation, and the quality of the thrombus depends upon the biomechanical environment. The goal of this study was to investigate how coil…
View article: Endothelial Responses to Curvature-Induced Flow Patterns in Engineered Cerebral Aneurysms
Endothelial Responses to Curvature-Induced Flow Patterns in Engineered Cerebral Aneurysms Open
Hemodynamic factors have long been associated with clinical outcomes in the treatment of cerebral aneurysms. Computational studies of cerebral aneurysm hemodynamics have provided valuable estimates of the mechanical environment experienced…
View article: Can Endovascular Treatment of Fusiform Intracranial Aneurysms Restore the Healthy Hemodynamic Environment?–A Virtual Pilot Study
Can Endovascular Treatment of Fusiform Intracranial Aneurysms Restore the Healthy Hemodynamic Environment?–A Virtual Pilot Study Open
Numerous studies assess intracranial aneurysm rupture risk based on morphological and hemodynamic parameter analysis in addition to clinical information such as aneurysm localization, age, and sex. However, intracranial aneurysms mostly oc…
View article: Correlation of Black Blood MRI with Image- Based Blood Flow Simulations in Intracranial Aneurysms
Correlation of Black Blood MRI with Image- Based Blood Flow Simulations in Intracranial Aneurysms Open
Intracranial aneurysms (IA) is not-uncommon pathology of cerebral vessels. Vessel wall magnetic resonance imaging can visualize the vascular walls of IAs. In some aneurysms, the wall-adjacent and a luminal hyperintense signal was detected.…
View article: P-056 Improved fluid dynamics simulations of coiled cerebral aneurysms using microtomography and homogenization techniques
P-056 Improved fluid dynamics simulations of coiled cerebral aneurysms using microtomography and homogenization techniques Open
Hemodynamic changes after aneurysm coiling can be simulated using computational fluid dynamics (CFD) to better predict treatment outcomes. Since the geometry of the coil mass is not visible using conventional imaging, most CFD simulations…
View article: Lagrangian Trajectory Simulation of Platelets and Synchrotron Microtomography Augment Hemodynamic Analysis of Intracranial Aneurysms Treated With Embolic Coils
Lagrangian Trajectory Simulation of Platelets and Synchrotron Microtomography Augment Hemodynamic Analysis of Intracranial Aneurysms Treated With Embolic Coils Open
As frequency of endovascular treatments for intracranial aneurysms increases, there is a growing need to understand the mechanisms for coil embolization failure. Computational fluid dynamics (CFD) modeling often simplifies modeling the end…
View article: E-194 Patient-specific hemodynamics predict endovascular coiling outcomes for intracranial aneurysms
E-194 Patient-specific hemodynamics predict endovascular coiling outcomes for intracranial aneurysms Open
Introduction Embolic coils are a preferred endovascular treatment technique for intracranial aneurysms, but approximately 34% of these treatments are unsuccessful, requiring re-treatment. To better understand why endovascular treatment fai…