Lauren E. Ethridge
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View article: Aberrant Neural Entrainment to Word-Level Speech Patterns in Fragile X Syndrome: Evidence for a Statistical Learning Deficit
Aberrant Neural Entrainment to Word-Level Speech Patterns in Fragile X Syndrome: Evidence for a Statistical Learning Deficit Open
Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism spectrum disorder, causes significant language and cognitive impairments. Statistical learning refers to the ability to extract patterns from s…
View article: FX ENTRAIN: scientific context, study design, and biomarker driven brain-computer interfaces in neurodevelopmental conditions
FX ENTRAIN: scientific context, study design, and biomarker driven brain-computer interfaces in neurodevelopmental conditions Open
Fragile X Syndrome (FXS), caused by the loss of function of the Fmr1 gene, is characterized by varying degrees of intellectual disability, autistic features, and sensory hypersensitivity. Despite phenotypic rescue in animal deletion models…
View article: ROC Analysis of Biomarker Combinations in Fragile X Syndrome-Specific Clinical Trials: Evaluating Treatment Efficacy via Exploratory Biomarkers
ROC Analysis of Biomarker Combinations in Fragile X Syndrome-Specific Clinical Trials: Evaluating Treatment Efficacy via Exploratory Biomarkers Open
Fragile X Syndrome (FXS) is a rare neurodevelopmental disorder caused by a trinucleotide repeat expansion on the 5' untranslated region of the FMR1 gene. FXS is characterized by intellectual disability, anxiety, sensory hypersensitivity, a…
View article: ROC Analysis of Biomarker Combinations in Fragile X Syndrome-Specific Clinical Trials: Evaluating Treatment Efficacy via Exploratory Biomarkers
ROC Analysis of Biomarker Combinations in Fragile X Syndrome-Specific Clinical Trials: Evaluating Treatment Efficacy via Exploratory Biomarkers Open
Fragile X Syndrome (FXS) is a rare neurodevelopmental disorder caused by a trinucleotide repeat expansion on the 5’ untranslated region of the FMR1 gene. FXS is characterized by intellectual disability, anxiety, sensory hypersensitivity, a…
View article: Event-Related Spatio-Spectral Perturbation (ERSSP): A Scalp-Wide EEG Analysis Framework for Capturing Extralemniscal Thalamocortical Activity, Validated Using a Fragile X Syndrome Model
Event-Related Spatio-Spectral Perturbation (ERSSP): A Scalp-Wide EEG Analysis Framework for Capturing Extralemniscal Thalamocortical Activity, Validated Using a Fragile X Syndrome Model Open
The extralemniscal thalamocortical pathway regulates large-scale modulation of cortical states but remains inaccessible to traditional EEG analysis due to its diffuse, variable, and asynchronous nature. To address this, we introduce the Ev…
View article: Frontal cortex hyperactivation and gamma desynchrony in Fragile X syndrome: Correlates of auditory hypersensitivity
Frontal cortex hyperactivation and gamma desynchrony in Fragile X syndrome: Correlates of auditory hypersensitivity Open
Fragile X syndrome (FXS) is an X-linked disorder that often leads to intellectual disability, anxiety, and sensory hypersensitivity. While sound sensitivity (hyperacusis) is a distressing symptom in FXS, its neural basis is not well unders…
View article: A human electrophysiological biomarker of Fragile X Syndrome is shared in V1 of <i>Fmr1</i> KO mice and caused by loss of FMRP in cortical excitatory neurons
A human electrophysiological biomarker of Fragile X Syndrome is shared in V1 of <i>Fmr1</i> KO mice and caused by loss of FMRP in cortical excitatory neurons Open
Predicting clinical therapeutic outcomes from preclinical animal studies remains an obstacle to developing treatments for neuropsychiatric disorders. Electrophysiological biomarkers analyzed consistently across species could bridge this di…
View article: A Tutorial on Supervised Machine Learning Variable Selection Methods in Classification for the Social and Health Sciences in R
A Tutorial on Supervised Machine Learning Variable Selection Methods in Classification for the Social and Health Sciences in R Open
With the increasing availability of large datasets in the behavioral and health sciences, the need for efficient and effective variable selection techniques has grown. While traditional methods like stepwise regression remain prevalent, nu…
View article: Auditory steady-state response deficits in Fragile X Syndrome implicate deficits in stimulus representation maintenance and GABAergic modulation
Auditory steady-state response deficits in Fragile X Syndrome implicate deficits in stimulus representation maintenance and GABAergic modulation Open
Background Fragile X Syndrome (FXS) is a rare, neurodevelopmental disorder caused by a mutation to the Fragile X messenger ribonucleoprotein 1 ( Fmr1 ) gene and characterized by sensory processing abnormalities and sensitivities, including…
View article: Auditory N1 event-related potential amplitude is predictive of serum concentration of BPN14770 in fragile X syndrome
Auditory N1 event-related potential amplitude is predictive of serum concentration of BPN14770 in fragile X syndrome Open
Fragile X syndrome (FXS) is a rare neurodevelopmental disorder caused by a CGG repeat expansion ≥ 200 repeats in 5’ untranslated region of the FMR1 gene, leading to intellectual disability and cognitive difficulties, including in the domai…
View article: Validating brain activity measures as reliable indicators of individual diagnostic group and genetically mediated sub-group membership in Fragile X Syndrome
Validating brain activity measures as reliable indicators of individual diagnostic group and genetically mediated sub-group membership in Fragile X Syndrome Open
Recent failures translating preclinical behavioral treatment effects to positive clinical trial results in humans with Fragile X Syndrome (FXS) support refocusing attention on biological pathways and associated measures, such as electroenc…
View article: Frontal Cortex Hyperactivation and Gamma Desynchrony in Fragile X Syndrome: Correlates of Auditory Hypersensitivity
Frontal Cortex Hyperactivation and Gamma Desynchrony in Fragile X Syndrome: Correlates of Auditory Hypersensitivity Open
Fragile X syndrome (FXS) is an X-linked disorder that often leads to intellectual disability, anxiety, and sensory hypersensitivity. While sound sensitivity (hyperacusis) is a distressing symptom in FXS, its neural basis is not well unders…
View article: A Tutorial on Supervised Machine Learning Variable Selection Methods for the Social and Health Sciences in R
A Tutorial on Supervised Machine Learning Variable Selection Methods for the Social and Health Sciences in R Open
With recent increases in the size of datasets currently available in the behavioral and health sciences, the need for efficient and effective variable selection techniques has increased. A plethora of techniques exist, yet only a few are u…
View article: A Tutorial on Supervised Machine Learning Variable Selection Methods for the Social and Health Sciences in R
A Tutorial on Supervised Machine Learning Variable Selection Methods for the Social and Health Sciences in R Open
With recent increases in the size of datasets currently available in the psychological sciences, the need for efficient and effective variable selection techniques has increased. A plethora of techniques exist, yet only a few are used with…
View article: A Tutorial on Supervised Machine Learning Variable Selection Methods for the Social and Health Sciences in R
A Tutorial on Supervised Machine Learning Variable Selection Methods for the Social and Health Sciences in R Open
With recent increases in the size of datasets currently available in the psychological sciences, the need for efficient and effective variable selection techniques has increased. A plethora of techniques exist, yet only a few are used with…
View article: Validating brain activity measures as reliable indicators of individual diagnostic group and genetically mediated sub-group membership Fragile X Syndrome
Validating brain activity measures as reliable indicators of individual diagnostic group and genetically mediated sub-group membership Fragile X Syndrome Open
Recent failures translating preclinical behavioral treatment effects to positive clinical trial results in humans with Fragile X Syndrome (FXS) support refocusing attention on biological pathways and associated measures, such as electroenc…
View article: Effects of AFQ056 on language learning in fragile X syndrome
Effects of AFQ056 on language learning in fragile X syndrome Open
BACKGROUNDFXLEARN, the first-ever large multisite trial of effects of disease-targeted pharmacotherapy on learning, was designed to explore a paradigm for measuring effects of mechanism-targeted treatment in fragile X syndrome (FXS). In FX…
View article: Editorial: Neural markers of sensory processing in development
Editorial: Neural markers of sensory processing in development Open
EDITORIAL article Front. Integr. Neurosci., 21 July 2023 Volume 17 - 2023 | https://doi.org/10.3389/fnint.2023.1256437
View article: Empirical Frequency Bound Derivation Reveals Prominent Mid-Frontal Alpha Associated with Neurosensory Dysfunction in Fragile X Syndrome
Empirical Frequency Bound Derivation Reveals Prominent Mid-Frontal Alpha Associated with Neurosensory Dysfunction in Fragile X Syndrome Open
The FMR1 gene is inactive in Fragile X syndrome (FXS), resulting in low levels of FMRP and consequent neurochemical, synaptic, and local circuit neurophysiological alterations in the fmr1 KO mouse. In FXS patients, electrophysiological stu…
View article: Neuropsychiatric feature-based subgrouping reveals neural sensory processing spectrum in female FMR1 premutation carriers: A pilot study
Neuropsychiatric feature-based subgrouping reveals neural sensory processing spectrum in female FMR1 premutation carriers: A pilot study Open
Introduction Fragile X Syndrome (FXS) is rare genetic condition characterized by a repeat expansion (CGG) in the Fragile X messenger ribonucleoprotein 1 (FMR1) gene where individuals with greater than 200 repeats are defined as full mutati…
View article: Hemispheric Utilization of Alpha Oscillatory Dynamics as a Unique Biomarker of Neural Compensation in Females with Fragile X Syndrome
Hemispheric Utilization of Alpha Oscillatory Dynamics as a Unique Biomarker of Neural Compensation in Females with Fragile X Syndrome Open
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a trinucleotide expansion on the FMR1 gene and characterized by intellectual disability, sensory hypersensitivity, executive function difficulties, and social anxiety. Rec…
View article: Baclofen-associated neurophysiologic target engagement across species in fragile X syndrome
Baclofen-associated neurophysiologic target engagement across species in fragile X syndrome Open
Background Fragile X syndrome (FXS) is the most common inherited form of neurodevelopmental disability. It is often characterized, especially in males, by intellectual disability, anxiety, repetitive behavior, social communication deficits…
View article: The multiple indicator multiple cause model for cognitive neuroscience: An analytic tool which emphasizes the behavior in brain–behavior relationships
The multiple indicator multiple cause model for cognitive neuroscience: An analytic tool which emphasizes the behavior in brain–behavior relationships Open
Cognitive neuroscience has inspired a number of methodological advances to extract the highest signal-to-noise ratio from neuroimaging data. Popular techniques used to summarize behavioral data include sum-scores and item response theory (…
View article: Temporal and frontal lobe contributions to neural synchronization dysfunction and auditory attention in Fragile X Syndrome
Temporal and frontal lobe contributions to neural synchronization dysfunction and auditory attention in Fragile X Syndrome Open
Fragile X syndrome (FXS) is a trinucleotide repeat disorder and the most common hereditary form of intellectual disability. Patients with FXS are commonly impaired by sensory hypersensitivity. Compared to cognition, neural correlates of se…
View article: Toward a Multidimensional Understanding of Misophonia Using Cluster-Based Phenotyping
Toward a Multidimensional Understanding of Misophonia Using Cluster-Based Phenotyping Open
Misophonia is a condition characterized by hypersensitivity and strong emotional reactivity to specific auditory stimuli. Misophonia clinical presentations are relatively complex and reflect individualized experiences across clinical popul…