Lauren E. Surface
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View article: Accelerated osteocytic citrate production in chronic kidney disease is associated with protection of the kidney
Accelerated osteocytic citrate production in chronic kidney disease is associated with protection of the kidney Open
Summary Patients with chronic kidney disease (CKD) face elevated fracture incidences, but mechanisms underlying CKD-related bone loss remain unclear. Using the adenine-induced chronic kidney injury (AdKI) murine model, we identified that A…
View article: <i>ATRAID</i> regulates the action of nitrogen-containing bisphosphonates on bone
<i>ATRAID</i> regulates the action of nitrogen-containing bisphosphonates on bone Open
ATRAID is essential for responses to the commonly prescribed osteoporosis drugs nitrogen-containing bisphosphonates.
View article: Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates
Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates Open
Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies have established that N-BPs function by inhibiting the mevalonate pathway i…
View article: Author response: Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates
Author response: Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates Open
Article Figures and data Abstract eLife digest Introduction Results and discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Nitrogen-containing-bisph…
View article: Identification and characterization of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates
Identification and characterization of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates Open
Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies have established that N-BPs function by inhibiting the mevalonate pathway i…
View article: Disruption of H2A.Z acidic patch increases chromatin dynamics in a transcription-dependent manner.
Disruption of H2A.Z acidic patch increases chromatin dynamics in a transcription-dependent manner. Open
(A) qRT-PCR results showing a decrease in the transcript levels of active genes- Oct4, Tubb5, and Actin, upon treatment of 1 µM flavopiridol and restoration of transcript levels upon removal of the agent at the various time points in H2A.Z…