Lauren K. Walsh
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View article: Dissemination of a facilitation strategy to de-implement unnecessary post-operative antibiotics at children's hospitals: The Optimizing Perioperative Antibiotic in Children (OPerAtiC) trial 2.0
Dissemination of a facilitation strategy to de-implement unnecessary post-operative antibiotics at children's hospitals: The Optimizing Perioperative Antibiotic in Children (OPerAtiC) trial 2.0 Open
View article: Establishing Priority Pediatric Antimicrobial Stewardship Interventions in the US: Findings from a Delphi Consensus Study
Establishing Priority Pediatric Antimicrobial Stewardship Interventions in the US: Findings from a Delphi Consensus Study Open
Background/Objectives: Antimicrobial resistance (AMR) is a major global health threat, with children at higher risk due to developmental differences in drug metabolism, limited treatment options and inappropriate antibiotic use. Pediatric …
View article: De novo Variants Disrupt an LDB1-Regulated Transcriptional Network in Congenital Ventriculomegaly
De novo Variants Disrupt an LDB1-Regulated Transcriptional Network in Congenital Ventriculomegaly Open
View article: A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus
A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus Open
Hydrocephalus, characterized by cerebral ventriculomegaly, is the most common disorder requiring brain surgery in children. Recent studies have implicated SMARCC1, a component of the BRG1-associated factor (BAF) chromatin remodelling compl…
View article: AB104. The choice of anaesthetic technique for cataract surgery
AB104. The choice of anaesthetic technique for cataract surgery Open
Background: Our study examined the choice of anaesthetic technique employed for cataract surgeries in the University Hospital Limerick. We looked at the number of cataract surgeries performed using the Sub-Tenon’s block technique and compa…
View article: Metabolic Implications of Diet and Energy Intake during Physical Inactivity
Metabolic Implications of Diet and Energy Intake during Physical Inactivity Open
Purpose Physical inactivity is associated with disruptions in glucose metabolism and energy balance, whereas energy restriction may blunt these adverse manifestations. During hypocaloric feeding, higher-protein intake maintains lean mass w…
View article: Increased endothelial shear stress improves insulin‐stimulated vasodilatation in skeletal muscle
Increased endothelial shear stress improves insulin‐stimulated vasodilatation in skeletal muscle Open
Key points It has been postulated that increased blood flow‐associated shear stress on endothelial cells is an underlying mechanism by which physical activity enhances insulin‐stimulated vasodilatation. This report provides evidence suppor…
View article: When gain is greater than loss: effects of physical activity on insulin sensitivity after short‐term inactivity in older subjects
When gain is greater than loss: effects of physical activity on insulin sensitivity after short‐term inactivity in older subjects Open
Lack of physical activity is an instigator of numerous chronic diseases and a leading cause of mortality in the Western world (Booth et al. 2012). Among the chronic diseases most influenced by physical inactivity are metabolic and cardiova…
View article: Prolonged leg bending impairs endothelial function in the popliteal artery
Prolonged leg bending impairs endothelial function in the popliteal artery Open
Uninterrupted sitting blunts vascular endothelial function in the lower extremities; however, the factors contributing to this impairment remain largely unknown. Herein, we tested the hypothesis that prolonged flexion of the hip and knee j…
View article: Prior exercise and standing as strategies to circumvent sitting-induced leg endothelial dysfunction
Prior exercise and standing as strategies to circumvent sitting-induced leg endothelial dysfunction Open
We have previously shown that local heating or leg fidgeting can prevent prolonged sitting-induced leg endothelial dysfunction. However, whether physical activity prevents subsequent sitting-induced leg endothelial dysfunction remains unkn…
View article: Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load
Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load Open
Postprandial hyperglycaemia leads to a transient impairment in endothelial function; however, the mechanisms remain largely unknown. Previous work in cell culture models demonstrate that high glucose results in endoplasmic reticulum (ER) s…
View article: An Article on Early Changes in Lipoproteins Following Elective Cardiac Surgery
An Article on Early Changes in Lipoproteins Following Elective Cardiac Surgery Open
View article: Prolonged sitting-induced leg endothelial dysfunction is prevented by fidgeting
Prolonged sitting-induced leg endothelial dysfunction is prevented by fidgeting Open
Prolonged sitting impairs endothelial function in the leg vasculature, and this impairment is thought to be largely mediated by a sustained reduction in blood flow-induced shear stress. Indeed, preventing the marked reduction of shear stre…