Lauren K. Wareham
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View article: Making tracks: microglia and the extracellular matrix
Making tracks: microglia and the extracellular matrix Open
Microglia are resident immune cells of the central nervous system (CNS) and critical regulators of neural homeostasis, mediating immune surveillance, synaptic remodeling, debris clearance, and inflammatory signaling. Emerging evidence high…
View article: Topical Application of a Collagen Mimetic Peptide Restores Peripapillary Scleral Stiffness Reduced by Ocular Stress
Topical Application of a Collagen Mimetic Peptide Restores Peripapillary Scleral Stiffness Reduced by Ocular Stress Open
Background: The biomechanical properties of ocular tissues are critical to physiological processes that span ocular development, aging, and disease. The structural integrity of these tissues is important in mediating how the eye responds t…
View article: Cover Image, Volume 73, Issue 7
Cover Image, Volume 73, Issue 7 Open
View article: Collagen mimetic peptides as novel therapeutics for vascular disease in the central nervous system
Collagen mimetic peptides as novel therapeutics for vascular disease in the central nervous system Open
Background Loss of vascular integrity is a common comorbidity of neurodegenerative diseases of the central nervous system (CNS). Compromised blood flow to the brain and excessive vascular remodeling is evident in chronic systemic cardiovas…
View article: Potassium‐Dependent Coupling of Retinal Astrocyte Light Response to Müller Glia
Potassium‐Dependent Coupling of Retinal Astrocyte Light Response to Müller Glia Open
Astrocytes throughout the central nervous system mediate a variety of functions to support proper tissue physiology, including the regulation of blood flow and providing metabolic support to neurons. There is also growing appreciation for …
View article: Adverse effects of CXCR2 deficiency in mice reared under non-gnotobiotic conditions
Adverse effects of CXCR2 deficiency in mice reared under non-gnotobiotic conditions Open
The family of pro-inflammatory and pro-angiogenic chemokines including Interleukin-8 (IL-8, aka CXCL8) and its homologues (CXCL1,2,3,5,6, and 7) exhibit promiscuous binding and activation of several G-protein-coupled receptors (i.e., CXCR2…
View article: Chronic hyperglycemia alters retinal astrocyte microstructure and uptake of cholera toxin B in a murine model of diabetes
Chronic hyperglycemia alters retinal astrocyte microstructure and uptake of cholera toxin B in a murine model of diabetes Open
Astrocytes are the principle glial cells of the central nervous system and play an active role in maintaining proper metabolism in surrounding neurons. Because of their involvement in metabolic control, it is likely that their physiology c…
View article: Morphological and electrophysiological characterization of a novel displaced astrocyte in the mouse retina
Morphological and electrophysiological characterization of a novel displaced astrocyte in the mouse retina Open
Astrocytes throughout the central nervous system are heterogeneous in both structure and function. This diversity leads to tissue‐specific specialization where morphology is adapted to the surrounding neuronal circuitry, as seen in Bergman…
View article: Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments
Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments Open
Glaucoma is the leading cause of irreversible blindness globally. The disease causes vision loss due to neurodegeneration of the retinal ganglion cell (RGC) projection to the brain through the optic nerve. Glaucoma is associated with sensi…
View article: Collagen in the central nervous system: contributions to neurodegeneration and promise as a therapeutic target
Collagen in the central nervous system: contributions to neurodegeneration and promise as a therapeutic target Open
The extracellular matrix is a richly bioactive composition of substrates that provides biophysical stability, facilitates intercellular signaling, and both reflects and governs the physiological status of the local microenvironment. The ma…
View article: Collagen Mimetic Peptides Promote Repair of MMP-1-Damaged Collagen in the Rodent Sclera and Optic Nerve Head
Collagen Mimetic Peptides Promote Repair of MMP-1-Damaged Collagen in the Rodent Sclera and Optic Nerve Head Open
The structural and biomechanical properties of collagen-rich ocular tissues, such as the sclera, are integral to ocular function. The degradation of collagen in such tissues is associated with debilitating ophthalmic diseases such as glauc…
View article: Retinal astrocyte morphology predicts integration of vascular and neuronal architecture
Retinal astrocyte morphology predicts integration of vascular and neuronal architecture Open
Astrocytes are important regulators of blood flow and play a key role in the response to injury and disease in the central nervous system (CNS). Despite having an understanding that structural changes to these cells have consequences for l…
View article: Collagen mimetic peptide repair of the corneal nerve bed in a mouse model of dry eye disease
Collagen mimetic peptide repair of the corneal nerve bed in a mouse model of dry eye disease Open
The intraepithelial sub-basal nerve plexus of the cornea is characterized by a central swirl of nerve processes that terminate between the apical cells of the epithelium. This plexus is a critical component of maintaining homeostatic funct…
View article: cGMP Signaling in the Neurovascular Unit—Implications for Retinal Ganglion Cell Survival in Glaucoma
cGMP Signaling in the Neurovascular Unit—Implications for Retinal Ganglion Cell Survival in Glaucoma Open
Glaucoma is a progressive age-related disease of the visual system and the leading cause of irreversible blindness worldwide. Currently, intraocular pressure (IOP) is the only modifiable risk factor for the disease, but even as IOP is lowe…
View article: Ex Vivo Integration of Human Stem Retinal Ganglion Cells into the Mouse Retina
Ex Vivo Integration of Human Stem Retinal Ganglion Cells into the Mouse Retina Open
Cell replacement therapies may be key in achieving functional recovery in neurodegenerative optic neuropathies diseases such as glaucoma. One strategy that holds promise in this regard is the use of human embryonic stem cell and induced pl…
View article: Adamts10 controls transforming growth factor β family signaling that contributes to retinal ganglion cell development
Adamts10 controls transforming growth factor β family signaling that contributes to retinal ganglion cell development Open
Although mutations in ADAMTS10 have long been known to cause autosomal recessive Weill-Marchesani Syndrome which is characterized by short stature and ocular abnormalities, more recent work has shown that certain mutations in ADAMTS10 caus…
View article: Dynamic Observation of Retinal Response to Pressure Elevation in a Microfluidic Chamber
Dynamic Observation of Retinal Response to Pressure Elevation in a Microfluidic Chamber Open
Dynamic observation of cell and tissue responses to elevated pressure could help our understanding of important physiological and pathological processes related to pressure-induced injury. Here, we report on a microfluidic platform capable…
View article: Lysyl oxidase-like 1 deficiency alters ultrastructural and biomechanical properties of the peripapillary sclera in mice
Lysyl oxidase-like 1 deficiency alters ultrastructural and biomechanical properties of the peripapillary sclera in mice Open
View article: Solving neurodegeneration: common mechanisms and strategies for new treatments
Solving neurodegeneration: common mechanisms and strategies for new treatments Open
Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss …
View article: Dysfunctional cGMP Signaling Leads to Age-Related Retinal Vascular Alterations and Astrocyte Remodeling in Mice
Dysfunctional cGMP Signaling Leads to Age-Related Retinal Vascular Alterations and Astrocyte Remodeling in Mice Open
The nitric oxide–guanylyl cyclase-1–cyclic guanylate monophosphate (NO–GC-1–cGMP) pathway is integral to the control of vascular tone and morphology. Mice lacking the alpha catalytic domain of guanylate cyclase (GC1−/−) develop retinal gan…
View article: Interleukin-6 promotes microtubule stability in axons via Stat3 protein–protein interactions
Interleukin-6 promotes microtubule stability in axons via Stat3 protein–protein interactions Open
View article: Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration
Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration Open
Astrocytes are intimately involved in the response to neurodegenerative stress and have become an attractive target for the development of neuroprotective therapies. However, studies often focus on astrocytes as single-cell units. Astrocyt…
View article: Insulin Signaling as a Therapeutic Target in Glaucomatous Neurodegeneration
Insulin Signaling as a Therapeutic Target in Glaucomatous Neurodegeneration Open
Glaucoma is a multifactorial disease that is conventionally managed with treatments to lower intraocular pressure (IOP). Despite these efforts, many patients continue to lose their vision. The degeneration of retinal ganglion cells (RGCs) …
View article: Protect, Repair, and Regenerate: Towards Restoring Vision in Glaucoma
Protect, Repair, and Regenerate: Towards Restoring Vision in Glaucoma Open
Purpose of Review We summarize recent advances in strategies that aim to restore optic nerve function and vision in glaucoma through protective, reparative, and regenerative avenues. Recent Findings Neuroprotection relies on identification…
View article: Role of Carbon Monoxide in Host–Gut Microbiome Communication
Role of Carbon Monoxide in Host–Gut Microbiome Communication Open
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between host and mutualistic bacteria is attracting increasing attention to the degree that the gut microbiome is proposed by some as a new organ system…
View article: The Neurovascular Unit in Glaucomatous Neurodegeneration
The Neurovascular Unit in Glaucomatous Neurodegeneration Open
Glaucoma is a neurodegenerative disease of the visual system and leading cause of blindness worldwide. The disease is associated with sensitivity to intraocular pressure (IOP), which over a large range of magnitudes stresses retinal gangli…
View article: Impairment of Membrane Repolarization Accompanies Axon Transport Deficits in Glaucoma
Impairment of Membrane Repolarization Accompanies Axon Transport Deficits in Glaucoma Open
Glaucoma is a leading cause of blindness worldwide, resulting from degeneration of retinal ganglion cells (RGCs), which form the optic nerve. In glaucoma, axon transport deficits appear to precede structural degeneration of RGC axons. The …
View article: Pressure-dependent modulation of inward-rectifying K<sup>+</sup> channels: implications for cation homeostasis and K<sup>+</sup> dynamics in glaucoma
Pressure-dependent modulation of inward-rectifying K<sup>+</sup> channels: implications for cation homeostasis and K<sup>+</sup> dynamics in glaucoma Open
Glaucoma is the leading cause of blindness worldwide, resulting from degeneration of retinal ganglion cells (RGCs), which form the optic nerve. Prior to structural degeneration, RGCs exhibit physiological deficits. Müller glia provide home…
View article: Increased bioavailability of cyclic guanylate monophosphate prevents retinal ganglion cell degeneration
Increased bioavailability of cyclic guanylate monophosphate prevents retinal ganglion cell degeneration Open
View article: Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as ‘gasotransmitters’ in bacteria?
Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as ‘gasotransmitters’ in bacteria? Open
A gasotransmitter is defined as a small, generally reactive, gaseous molecule that, in solution, is generated endogenously in an organism and exerts important signalling roles. It is noteworthy that these molecules are also toxic and antim…