Lauren M. LaRocque
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View article: Aldosterone Contributes to Vasopressin Escape through Changes in Water and Urea Transport
Aldosterone Contributes to Vasopressin Escape through Changes in Water and Urea Transport Open
Hyponatremia (hypo-osmolality) is a disorder of water homeostasis due to abnormal renal diluting capacity. The body limits the degree to which serum sodium concentration falls through a mechanism called “vasopressin escape”. Vasopressin es…
View article: An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus
An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus Open
Nephrogenic diabetes insipidus (NDI) patients produce large amounts of dilute urine. NDI can be congenital, resulting from mutations in the type-2 vasopressin receptor (V2R), or acquired, resulting from medications such as lithium. There a…
View article: Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration
Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration Open
Summary Alzheimer’s disease (AD) is characterized by the appearance of amyloid-β plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Using mass spectrometry, we have quantified the phosphoproteome of the…
View article: Role of PKC and AMPK in hypertonicity-stimulated water reabsorption in rat inner medullary collecting ducts
Role of PKC and AMPK in hypertonicity-stimulated water reabsorption in rat inner medullary collecting ducts Open
Hypertonicity increases water permeability, independently of vasopressin, in the inner medullary collecting duct (IMCD) by increasing aquaporin-2 (AQP2) membrane accumulation. We investigated whether protein kinase C (PKC) and adenosine mo…
View article: High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation
High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation Open
Natriuretic regulation of extracellular fluid volume homeostasis includes suppression of the renin-angiotensin-aldosterone system, pressure natriuresis, and reduced renal nerve activity, actions that concomitantly increase urinary Na+ excr…
View article: Metformin improves urine concentration in rodents with nephrogenic diabetes insipidus
Metformin improves urine concentration in rodents with nephrogenic diabetes insipidus Open
Urine concentration is regulated by vasopressin. Congenital nephrogenic diabetes insipidus (NDI) is caused by vasopressin type 2 receptor (V2R) mutations. We studied whether metformin could improve urine concentration in rodent models of c…
View article: Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts
Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts Open
Nephrogenic diabetes insipidus (NDI) is characterized by production of very large quantities of dilute urine due to an inability of the kidney to respond to vasopressin. Congenital NDI results from mutations in the type 2 vasopressin recep…