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View article: 1 Machine Learning Identifies Unrecognized IV Fluid Contamination of Complete Blood Counts That Motivates Potentially Unnecessary Red Blood Cell Transfusions
1 Machine Learning Identifies Unrecognized IV Fluid Contamination of Complete Blood Counts That Motivates Potentially Unnecessary Red Blood Cell Transfusions Open
Intravenous (IV) fluid contamination is uncommon, but often difficult to detect. When undetected, misinformed clinical decisions may lead to downstream consequences, such as unnecessary blood transfusion, whose frequencies may vary by inst…
View article: On-Cell Stability of Digoxin, Lithium, Phenytoin, Valproic Acid, and Vancomycin for Therapeutic Drug Monitoring
On-Cell Stability of Digoxin, Lithium, Phenytoin, Valproic Acid, and Vancomycin for Therapeutic Drug Monitoring Open
Background A common problem in clinical laboratories and outpatient clinics is processing specimens rapidly to comply with specimen stability criteria. Currently, for therapeutic drug monitoring, the laboratory must centrifuge specimens an…
View article: Blood Cell Agglutination Interference in Complete Blood Count Analysis
Blood Cell Agglutination Interference in Complete Blood Count Analysis Open
View article: Robert L. Schmidt, MD, PhD, MBA (November 17, 1952-October 25, 2023)
Robert L. Schmidt, MD, PhD, MBA (November 17, 1952-October 25, 2023) Open
View article: Rainbow phlebotomy collection and urine aliquots for emergency department add-on testing in the era of pandemic-driven supply shortages
Rainbow phlebotomy collection and urine aliquots for emergency department add-on testing in the era of pandemic-driven supply shortages Open
Background Rainbow blood draws for add-on testing in the emergency department (ED) are a common practice at our institution. We sought to determine the prevalence of this practice among reference laboratory clients and characterize the imp…
View article: A-163 Abnormal HbA1c Results Lead to an Unexpected Chronic Myeloid Leukemia Diagnosis
A-163 Abnormal HbA1c Results Lead to an Unexpected Chronic Myeloid Leukemia Diagnosis Open
Background Hemoglobin A1c (HbA1c) is used to assess and monitor glycemic control, as it reflects average levels of blood glucose over the previous two to three months. HbA1c can be measured by capillary electrophoresis (CE) which calculate…
View article: Reported Awareness and Adoption of 2021 Estimated Glomerular Filtration Rate Equations Among US Clinical Laboratories, March 2022
Reported Awareness and Adoption of 2021 Estimated Glomerular Filtration Rate Equations Among US Clinical Laboratories, March 2022 Open
This study includes clinical laboratories that participated in the first general chemistry proficiency testing survey in 2022 to assess awareness and adoption of new equations from the Chronic Kidney Disease Epidemiology Collaboration for …
View article: On-Cell Stability for Therapeutic Drug Monitoring
On-Cell Stability for Therapeutic Drug Monitoring Open
Introduction A common problem in many clinical laboratories and outpatient clinics is processing specimens rapidly to comply with specimen stability criteria. Labs receive thousands of samples a day and may face challenges with staffing, e…
View article: Measurement of Urinary Ammonium Using a Commercially Available Plasma Ammonium Assay
Measurement of Urinary Ammonium Using a Commercially Available Plasma Ammonium Assay Open
Key Points Plasma ammonium assay reliably quantifies urine ammonium at physiologic concentrations. The enzymatic method compares well with the formalin titration method and is suitable for routine clinical use. Background Determination of …
View article: The effect of the Covid-19 shutdown on glycemic testing and control
The effect of the Covid-19 shutdown on glycemic testing and control Open
View article: Side-Effects of COVID-19 on Patient Care: An INR Story
Side-Effects of COVID-19 on Patient Care: An INR Story Open
Background Numerous studies have documented reduced access to patient care due to the COVID-19 pandemic, including access to diagnostic or screening tests, prescription medications, and treatment for an ongoing condition. In the context of…
View article: Performance Characteristics of BinaxNOW COVID-19 Antigen Card for Screening Asymptomatic Individuals in a University Setting
Performance Characteristics of BinaxNOW COVID-19 Antigen Card for Screening Asymptomatic Individuals in a University Setting Open
We compared the performance of the Abbott BinaxNOW COVID-19 antigen card to that of a standard reverse transcription-PCR (RT-PCR) assay (Thermo Fisher TaqPath COVID-19 Combo kit) for the detection of severe acute respiratory syndrome coron…
View article: D-Dimer Varies Widely Across Instrument Platforms and is Not a Reliable Indicator of Periprosthetic Joint Infections
D-Dimer Varies Widely Across Instrument Platforms and is Not a Reliable Indicator of Periprosthetic Joint Infections Open
View article: 1783. More than Which Molecular Test: Following the Directions in How and Who to Test in the Diagnosis of Influenza
1783. More than Which Molecular Test: Following the Directions in How and Who to Test in the Diagnosis of Influenza Open
Background The CDC and IDSA recommend testing hospitalized patients with suspected influenza using molecular assays, in part to implement precautions to prevent transmission. Both PCR and a rapid isothermal nucleic acid amplification test …
View article: Detection and Quantification of FLT3 Internal Tandem Duplication Mutations Do Not Vary Significantly Between Whole Blood and Blast-Enriched Samples
Detection and Quantification of FLT3 Internal Tandem Duplication Mutations Do Not Vary Significantly Between Whole Blood and Blast-Enriched Samples Open
Objectives Many commonly used FLT3 mutational assay protocols require a tedious blast enrichment step. We investigated whether elimination of this step would still give equivalent results and compared the accuracy of variant allele fractio…
View article: An Analysis of Multirules for Monitoring Assay Quality Control
An Analysis of Multirules for Monitoring Assay Quality Control Open
Background Multirules are often employed to monitor quality control (QC). The performance of multirules is usually determined by simulation and is difficult to predict. Previous studies have not provided computer code that would enable one…
View article: Method Verification Shows a Negative Bias between 2 Procalcitonin Methods at Medical Decision Concentrations
Method Verification Shows a Negative Bias between 2 Procalcitonin Methods at Medical Decision Concentrations Open
Background Procalcitonin (PCT) concentration increases as a result of systemic inflammation owing to bacterial infection. Many PCT algorithms and medical decision concentrations (MDCs) have been clinically validated using the B·R·A·H·M·S P…
View article: Combined Pathology-Driven Algorithmic Testing and Integrated Reporting for Bone Marrow Examination
Combined Pathology-Driven Algorithmic Testing and Integrated Reporting for Bone Marrow Examination Open
Context.— The College of American Pathologists published guideline recommending bone marrow synoptic reporting for hematologic neoplasms. Objective.— To evaluate the impact of pathology-driven algorithmic testing (PDAT) with integrated rep…
View article: Cost‐effectiveness of rapid on‐site evaluation of the adequacy of FNA cytology samples performed by nonpathologists
Cost‐effectiveness of rapid on‐site evaluation of the adequacy of FNA cytology samples performed by nonpathologists Open
Background Rapid on‐site evaluation (ROSE) can increase adequacy and reduce needle passes in fine‐needle aspiration cytology (FNAC) procedures. However, ROSE increases the cost of FNAC. Costs may be reduced if ROSE is performed by an alter…
View article: Issue Information
Issue Information Open
This news section is written by a medical journalist and offers Cancer Cytopathology readers timely information on events, issues, and personalities of interest to the subspecialty.This edition explores the hidden costs of surviving childh…
View article: Verification of BRAHMS Procalcitonin (PCT) Assay Performance on Two ARCHITECT i2000SR Analyzers
Verification of BRAHMS Procalcitonin (PCT) Assay Performance on Two ARCHITECT i2000SR Analyzers Open
Healthy individuals present with PCT levels below 0.1 ng/mL. A rapid rise in PCT occurs during systemic inflammation, particularly secondary to bacterial infection. PCT concentration is a specific and valuable indicator of sepsis risk prog…
View article: A Reflex Protocol for Creatinine Testing Reduces Costs and Maintains Patient Safety
A Reflex Protocol for Creatinine Testing Reduces Costs and Maintains Patient Safety Open
The reflex protocol for creatinine measurement can reduce costs with acceptable risk.
View article: Peritoneal and Pleural Fluid Chemistry Measurements Performed on Three Chemistry Platforms
Peritoneal and Pleural Fluid Chemistry Measurements Performed on Three Chemistry Platforms Open
These data suggest that analyses of pleural and peritoneal fluids using these platforms are diagnostically interchangeable.
View article: Supplementary Material for: Rapid On-Site Evaluation of Fine-Needle Aspiration by Non-Cytopathologists: A Systematic Review and Meta-Analysis of Diagnostic Accuracy Studies for Adequacy Assessment
Supplementary Material for: Rapid On-Site Evaluation of Fine-Needle Aspiration by Non-Cytopathologists: A Systematic Review and Meta-Analysis of Diagnostic Accuracy Studies for Adequacy Assessment Open
Objective: Rapid on-site evaluation (ROSE) has been shown to improve adequacy rates and reduce needle passes. ROSE is often performed by cytopathologists who have limited availability and may be costlier than alternatives. Se…
View article: Supplementary Material for: Diagnostic Accuracy of Fine-Needle Aspiration Cytology for Discrimination of Squamous Cell Carcinoma from Adenocarcinoma in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
Supplementary Material for: Diagnostic Accuracy of Fine-Needle Aspiration Cytology for Discrimination of Squamous Cell Carcinoma from Adenocarcinoma in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis Open
Objective: To determine the accuracy with which morphology alone can distinguish adenocarcinoma and squamous cell carcinoma in non-small cell lung cancer. Methods: We performed a systematic review and meta-analy…