Lauren S. Koepke
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View article: KIF5A downregulation in spinal muscular atrophy links axonal regeneration defects with ALS
KIF5A downregulation in spinal muscular atrophy links axonal regeneration defects with ALS Open
Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder caused by mutations in the Survival Motor Neuron 1 (SMN1) gene, leading to decreased SMN levels and motor neuron dysfunction. SMN-restoring therapies offer clinical bene…
View article: Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites Open
The skeleton is one of the most structurally and compositionally diverse organ systems in the human body, depending on unique cellular dynamisms. Here, we integrate prospective isolation of human skeletal stem cells (hSSCs; CD45-CD235a-TIE…
View article: A Combination of Distinct Vascular Stem/Progenitor Cells for Neovascularization and Ischemic Rescue
A Combination of Distinct Vascular Stem/Progenitor Cells for Neovascularization and Ischemic Rescue Open
Background: Peripheral vascular disease remains a leading cause of vascular morbidity and mortality worldwide despite advances in medical and surgical therapy. Besides traditional approaches, which can only restore blood flow to native art…
View article: Distinct skeletal stem cell types orchestrate long bone skeletogenesis
Distinct skeletal stem cell types orchestrate long bone skeletogenesis Open
Skeletal stem and progenitor cell populations are crucial for bone physiology. Characterization of these cell types remains restricted to heterogenous bulk populations with limited information on whether they are unique or overlap with pre…
View article: Author response: Distinct skeletal stem cell types orchestrate long bone skeletogenesis
Author response: Distinct skeletal stem cell types orchestrate long bone skeletogenesis Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Skeletal stem and progenitor cell populati…
View article: Articular cartilage regeneration by activated skeletal stem cells
Articular cartilage regeneration by activated skeletal stem cells Open
Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of articular cartilage1. The etiology of OA is complex and involves a variety of factors, including genetic predisposition, acute injury and c…
View article: Geriatric fragility fractures are associated with a human skeletal stem cell defect
Geriatric fragility fractures are associated with a human skeletal stem cell defect Open
Fragility fractures have a limited capacity to regenerate, and impaired fracture healing is a leading cause of morbidity in the elderly. The recent identification of a highly purified bona fide human skeletal stem cell (hSSC) and its commi…
View article: Abstract QS34: Prospective Isolation of a Functional Human Cartilage Progenitor Capable of Forming Hyaline Cartilage In Vivo
Abstract QS34: Prospective Isolation of a Functional Human Cartilage Progenitor Capable of Forming Hyaline Cartilage In Vivo Open
PURPOSE: Over the past century, the average life span has increased by nearly 30%, leading to an overall aging population and an increase in degenerative diseases, including osteoarthritis. Due to a lack of vasculature and low cellularity …
View article: Abstract 58: Multimodal manipulation of the Skeletal Stem Cell for Articular Cartilage Regeneration
Abstract 58: Multimodal manipulation of the Skeletal Stem Cell for Articular Cartilage Regeneration Open
PURPOSE: With an aging population, degenerative diseases such as osteoarthritis are expected to increase. Hyaline cartilage has a poor propensity to regenerate. To ameliorate its healing capacity patients are being offered multiple “stem c…