Lauren S. Sherman
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View article: Initial responses of songbird communities to forest reclamation on legacy surface mines
Initial responses of songbird communities to forest reclamation on legacy surface mines Open
Surface coal mining and subsequent reclamation efforts in the Appalachian Mountains, USA, transform the ecological characteristics of natural landscapes. The Forestry Reclamation Approach (FRA) is a mine reclamation method that emphasizes …
View article: Bottlebrush Polymer Conjugates for Enhanced Antisense Oligonucleotide Therapy in Myotonic Dystrophy Type 1
Bottlebrush Polymer Conjugates for Enhanced Antisense Oligonucleotide Therapy in Myotonic Dystrophy Type 1 Open
Oligonucleotides are a promising genetic medicine for myotonic dystrophy type 1 (DM1), the most common adult-onset muscular dystrophy. However, poor muscle distribution of nucleic acid drugs after systemic administration has hindered drug …
View article: Advancing Science in Microgravity – Implications for Effective Therapies
Advancing Science in Microgravity – Implications for Effective Therapies Open
The International Space Station (ISS) is a collaborative platform for advanced research in microgravity, significantly contributing to cancer studies, drug development, and tissue engineering. Since its assembly in 1998, the ISS has become…
View article: An Overview of the Biological Processes of Mesenchymal Stem Cells and Their Response to an Inflammatory Milieu
An Overview of the Biological Processes of Mesenchymal Stem Cells and Their Response to an Inflammatory Milieu Open
There is continued interest in applying adult human mesenchymal stem cells (MSCs) in tissue regeneration, as well as mitigating overt inflammation such as graft versus host disease. MSCs are derived from different sources such as bone marr…
View article: Intercellular Interaction Between a Dental Pulp Stem Cell and Leukemia Cells – Support of Acute Myeloid Leukemia
Intercellular Interaction Between a Dental Pulp Stem Cell and Leukemia Cells – Support of Acute Myeloid Leukemia Open
The oral cavity is a site of hematopoietic activity, and metastatic hematological and solid tumors. This study focused on acute myeloid leukemia (AML) due to extensive documentation of its presentation in the gingiva. Despite these reports…
View article: Parallel Stem Cell Niche in Bone Marrow and Oral Cavity – Key to Extramedullary Hematopoiesis and Support of Hematological Malignancies on Oral Tissues
Parallel Stem Cell Niche in Bone Marrow and Oral Cavity – Key to Extramedullary Hematopoiesis and Support of Hematological Malignancies on Oral Tissues Open
This review article addresses an area of the literature with unanswered questions; although relevant to future treatment of leukemias. The literature describes bone marrow stromal microenvironment as support of leukemias. A key stromal sup…
View article: Aerospace Medicine – An Evolving Field to Mitigate and Treat Organ Dysfunction Partly Caused by Premature Aging in Low Microgravity
Aerospace Medicine – An Evolving Field to Mitigate and Treat Organ Dysfunction Partly Caused by Premature Aging in Low Microgravity Open
Space medicine is a branch of aerospace medicine, which is a crucial field, albeit with minimal research. Research at the International Space Station and other endeavors has provided insights into how loss of gravity could affect the physi…
View article: Wetland Creation and Reforestation of Legacy Surface Mines in the Central Appalachian Region (USA): A Potential Climate-Adaptation Approach for Pond-Breeding Amphibians?
Wetland Creation and Reforestation of Legacy Surface Mines in the Central Appalachian Region (USA): A Potential Climate-Adaptation Approach for Pond-Breeding Amphibians? Open
Habitat restoration and creation within human-altered landscapes can buffer the impacts of climate change on wildlife. The Forestry Reclamation Approach (FRA) is a coal surface mine reclamation practice that enhances reforestation through …
View article: Restore Veto Property in Low Dose Aspirin/ASA Treated Preeclampsia Placenta Mesenchymal Stem Cells: Insights Into ASA-mediated Clinical Response*
Restore Veto Property in Low Dose Aspirin/ASA Treated Preeclampsia Placenta Mesenchymal Stem Cells: Insights Into ASA-mediated Clinical Response* Open
Preeclampsia (PE) is a pregnancy complication characterized by elevated blood pressure, proteinuria, and other laboratory abnormalities. PE affects 2–8% of pregnancies globally and can lead to preterm birth and other complications for the …
View article: Early Initiative of Structured Mentoring and Research for Social Disadvantage Trainees to Increase Diversity and Inclusion among Clinician Scientists
Early Initiative of Structured Mentoring and Research for Social Disadvantage Trainees to Increase Diversity and Inclusion among Clinician Scientists Open
Overall, this training program could serve as a `blueprint' for other programs to enhance careers in research, and to narrow the diversity gap among clinician scientists. Diversity among clinician scientists will enhance healthcare and dis…
View article: Cryopreservation of Large Number of Human Hematopoietic Cells – A Model for Research Space with Limited Resources
Cryopreservation of Large Number of Human Hematopoietic Cells – A Model for Research Space with Limited Resources Open
Unlike cell lines, cells from primary human tissues are valuable, requiring storage for long-term use. Large number of primary cells require the most efficient method of shipment, when relevant, and cryopreservation to preserve the viabili…
View article: A Theory of Gravitational Generation to Mitigate Space-Induced Low Gravity – Relevance to Premature Aging in Space
A Theory of Gravitational Generation to Mitigate Space-Induced Low Gravity – Relevance to Premature Aging in Space Open
Artificial gravity is among the key goals for successful long-term space exploration. Over the last century, several possible theoretical models have been proposed. As far as we are aware, use of centrifugal rotation is the only major form…
View article: Serum exosomal microRNA pathway activation in placenta accreta spectrum: pathophysiology and detection
Serum exosomal microRNA pathway activation in placenta accreta spectrum: pathophysiology and detection Open
In this large cohort, plasma exosomal microRNA assessment revealed differentially expressed pathways in placenta accreta spectrum, and these microRNAs are potential biomarkers for the detection of placenta accreta spectrum.
View article: Impaired receptivity of thin endometrium: therapeutic potential of mesenchymal stem cells
Impaired receptivity of thin endometrium: therapeutic potential of mesenchymal stem cells Open
The endometrium is a resilient and highly dynamic tissue, undergoing cyclic renewal in preparation for embryo implantation. Cyclic endometrial regeneration depends on the intact function of several cell types, including parenchymal, endoth…
View article: Mesenchymal stem cell secretome alters gene expression and upregulates motility of human endometrial stromal cells
Mesenchymal stem cell secretome alters gene expression and upregulates motility of human endometrial stromal cells Open
In brief Endometrial stromal cell motility is fundamental to regeneration and repair of this tissue and crucial for successful reproduction. This paper shows a role for the mesenchymal stem cell (MSC) secretome in enhancing endometrial str…
View article: Supplementary Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region
Supplementary Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region Open
Methods, Supplemental Figs 1-7
View article: EV real time image from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region
EV real time image from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region Open
Shows EVs moving inside the cell
View article: Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region
Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region Open
In the bone marrow (BM), breast cancer cells (BCC) can survive in dormancy for decades as cancer stem cells (CSC), resurging as tertiary metastasis. The endosteal region where BCCs exist as CSCs poses a challenge to target them, mostly due…
View article: Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region
Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region Open
In the bone marrow (BM), breast cancer cells (BCC) can survive in dormancy for decades as cancer stem cells (CSC), resurging as tertiary metastasis. The endosteal region where BCCs exist as CSCs poses a challenge to target them, mostly due…
View article: Supplementary Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region
Supplementary Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region Open
Methods, Supplemental Figs 1-7
View article: EV real time image from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region
EV real time image from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region Open
Shows EVs moving inside the cell
View article: Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow
Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow Open
Breast cancer (BC) stem cells (CSCs) resist treatment and can exist as dormant cells in tissues such as the bone marrow (BM). Years before clinical diagnosis, BC cells (BCCs) could migrate from the primary site where the BM niche cells fac…
View article: Scaffolds containing <scp>GAG</scp>‐mimetic cellulose sulfate promote <scp>TGF</scp>‐β interaction and <scp>MSC</scp> Chondrogenesis over native <scp>GAGs</scp>
Scaffolds containing <span>GAG</span>‐mimetic cellulose sulfate promote <span>TGF</span>‐β interaction and <span>MSC</span> Chondrogenesis over native <span>GAGs</span> Open
Cartilage tissue engineering strategies seek to repair damaged tissue using approaches that include scaffolds containing components of the native extracellular matrix (ECM). Articular cartilage consists of glycosaminoglycans (GAGs) which a…
View article: Bone Marrow- and Umbilical Cord-Derived Mesenchymal Stem Cell Secretome Alters Gene Expression and Upregulates Motility of Human Endometrial Stromal Cells
Bone Marrow- and Umbilical Cord-Derived Mesenchymal Stem Cell Secretome Alters Gene Expression and Upregulates Motility of Human Endometrial Stromal Cells Open
Introduction Cyclic regeneration of the endometrium, and its repair after parturition or injury, are crucial for successful reproduction. Mesenchymal stem cells (MSCs) derived from bone marrow (BM-MSC) and umbilical cord (UC-MSC) facilitat…
View article: Mesenchymal Stem Cells and Pathotropism: Regenerative Potential and Safety Concerns
Mesenchymal Stem Cells and Pathotropism: Regenerative Potential and Safety Concerns Open
Mesenchymal Stem cells (MSCs) are ubiquitously expressed in several organs, but the major sites in adults are bone marrow and adipose tissue. MSCs can form several cells belonging to all germ layers, such as neurons and cardiomyocytes. MSC…
View article: Restoration of aged hematopoietic cells by their young counterparts through instructive microvesicles release
Restoration of aged hematopoietic cells by their young counterparts through instructive microvesicles release Open
This study addresses the potential to reverse age-associated morbidity by establishing methods to restore the aged hematopoietic system. Parabiotic animal models indicated that young secretome could restore aged tissues, leading us to esta…
View article: NFĸB Targeting in Bone Marrow Mesenchymal Stem Cell-Mediated Support of Age-Linked Hematological Malignancies.
NFĸB Targeting in Bone Marrow Mesenchymal Stem Cell-Mediated Support of Age-Linked Hematological Malignancies. Open
Mesenchymal stem cells (MSCs) can become dysfunctional in patients with hematological disorders. An unanswered question is whether age-linked disruption of the bone marrow (BM) microenvironment is secondary to hematological dysfunction or …
View article: A 3D Bioprinted Material That Recapitulates the Perivascular Bone Marrow Structure for Sustained Hematopoietic and Cancer Models
A 3D Bioprinted Material That Recapitulates the Perivascular Bone Marrow Structure for Sustained Hematopoietic and Cancer Models Open
Translational medicine requires facile experimental systems to replicate the dynamic biological systems of diseases. Drug approval continues to lag, partly due to incongruencies in the research pipeline that traditionally involve 2D models…
View article: Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region
Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region Open
In the bone marrow (BM), breast cancer cells (BCC) can survive in dormancy for decades as cancer stem cells (CSC), resurging as tertiary metastasis. The endosteal region where BCCs exist as CSCs poses a challenge to target them, mostly due…
View article: Restoration of Aged Hematopoietic Cells by Their Young Counterparts Through Instructive Microvesicle Release
Restoration of Aged Hematopoietic Cells by Their Young Counterparts Through Instructive Microvesicle Release Open