Lauren Sheehan
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View article: Upper limb motor recovery in chronic stroke—longitudinal aggregate analysis from control group outcomes
Upper limb motor recovery in chronic stroke—longitudinal aggregate analysis from control group outcomes Open
Introduction This study examines the effects of regular physical activity on upper extremity motor recovery during the late subacute and chronic phases of stroke. Methods Data were aggregated from 20 studies comprising 368 participants in …
View article: IpsiHand Brain–Computer Interface Therapy Induces Broad Upper Extremity Motor Rehabilitation in Chronic Stroke
IpsiHand Brain–Computer Interface Therapy Induces Broad Upper Extremity Motor Rehabilitation in Chronic Stroke Open
Background Chronic hemiparetic stroke patients have very limited benefits from current therapies. Brain–computer interface (BCI) engaging the unaffected hemisphere has emerged as a promising novel therapeutic approach for chronic stroke re…
View article: Feasibility of a Telemedicine-Based Principal Illness Navigation (PIN) Service for Complex Populations Following Hospital Discharge After Acute Stroke
Feasibility of a Telemedicine-Based Principal Illness Navigation (PIN) Service for Complex Populations Following Hospital Discharge After Acute Stroke Open
Background Principal Illness Navigation (PIN) services may play an important role in helping patients through important transitions in care following acute hospitalization. We evaluated a novel PIN telemedicine approach to understand the f…
View article: IpsiHand Brain-Computer Interface Therapy Induces Broad Upper Extremity Motor Recovery in Chronic Stroke
IpsiHand Brain-Computer Interface Therapy Induces Broad Upper Extremity Motor Recovery in Chronic Stroke Open
Background and Purpose Chronic hemiparetic stroke patients have very limited benefits from current therapies. Brain-computer interface (BCI) engaging the unaffected hemisphere has emerged as a promising novel therapeutic approach for chron…
View article: A Reverse Genetic Approach for Studying sRNAs in Chlamydia trachomatis
A Reverse Genetic Approach for Studying sRNAs in Chlamydia trachomatis Open
Small RNAs (sRNAs) are a class of regulatory RNAs that play important roles in bacterial physiology and pathogenesis. In the intracellular bacterium Chlamydia , however, sRNAs are poorly understood, and functional studies have been limited…
View article: The Small Molecule H89 Inhibits <i>Chlamydia</i> Inclusion Growth and Production of Infectious Progeny
The Small Molecule H89 Inhibits <i>Chlamydia</i> Inclusion Growth and Production of Infectious Progeny Open
Chlamydia is an obligate intracellular bacterium and the most common reportable cause of human infection in the United States. This pathogen proliferates inside a eukaryotic host cell, where it resides within a membrane-bound compartment c…
View article: A central role for the transcriptional regulator VtlR in small RNA-mediated gene regulation in Agrobacterium tumefaciens
A central role for the transcriptional regulator VtlR in small RNA-mediated gene regulation in Agrobacterium tumefaciens Open
View article: Characterizing the transport and utilization of the neurotransmitter GABA in the bacterial pathogen Brucella abortus
Characterizing the transport and utilization of the neurotransmitter GABA in the bacterial pathogen Brucella abortus Open
The neurotransmitter gamma-aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the human brain; however, it is becoming more evident that this non-proteinogenic amino acid plays multiple physiological roles in biol…
View article: The Endoribonuclease RNase E Coordinates Expression of mRNAs and Small Regulatory RNAs and Is Critical for the Virulence of Brucella abortus
The Endoribonuclease RNase E Coordinates Expression of mRNAs and Small Regulatory RNAs and Is Critical for the Virulence of Brucella abortus Open
Brucellosis is a debilitating disease of humans and animals globally, and there is currently no vaccine to combat human infection by Brucella spp. Moreover, effective antibiotic treatment in humans is extremely difficult and can lead to di…
View article: The Repressor Function of the <i>Chlamydia</i> Late Regulator EUO Is Enhanced by the Plasmid-Encoded Protein Pgp4
The Repressor Function of the <i>Chlamydia</i> Late Regulator EUO Is Enhanced by the Plasmid-Encoded Protein Pgp4 Open
Chlamydia trachomatis is an important human pathogen that causes more than 150 million active cases of genital and eye infection in the world. This obligate intracellular bacterium produces infectious progeny within an infected human cell …
View article: Characterization of Three Small Proteins in Brucella abortus Linked to Fucose Utilization
Characterization of Three Small Proteins in Brucella abortus Linked to Fucose Utilization Open
Despite being one of the most common zoonoses worldwide, there is currently no human vaccine to combat brucellosis. Therefore, a better understanding of the pathogenesis and biology of Brucella spp., the causative agent of brucellosis, is …
View article: Endoribonuclease YbeY Is Linked to Proper Cellular Morphology and Virulence in Brucella abortus
Endoribonuclease YbeY Is Linked to Proper Cellular Morphology and Virulence in Brucella abortus Open
The YbeY endoribonuclease is one of the best-conserved proteins across the kingdoms of life. In the present study, we demonstrated that YbeY in Brucella abortus is linked to a variety of important activities, including proper cellular morp…
View article: An account of evolutionary specialization: the AbcR small RNAs in the <i>Rhizobiales</i>
An account of evolutionary specialization: the AbcR small RNAs in the <i>Rhizobiales</i> Open
Summary The AbcR small RNAs (sRNAs) are a fascinating example of two highly conserved sRNAs that differ tremendously at the functional level among organisms. From their transcriptional activation to their regulatory capabilities, the AbcR …
View article: A 6-Nucleotide Regulatory Motif within the AbcR Small RNAs of <i>Brucella abortus</i> Mediates Host-Pathogen Interactions
A 6-Nucleotide Regulatory Motif within the AbcR Small RNAs of <i>Brucella abortus</i> Mediates Host-Pathogen Interactions Open
In Brucella abortus , two small RNAs (sRNAs), AbcR1 and AbcR2, are responsible for regulating transcripts encoding ABC-type transport systems. AbcR1 and AbcR2 are required for Brucella virulence, as a double chromosomal deletion of both sR…
View article: A <scp>LysR</scp>‐family transcriptional regulator required for virulence in <scp><i>B</i></scp><i>rucella abortus</i> is highly conserved among the α‐proteobacteria
A <span>LysR</span>‐family transcriptional regulator required for virulence in <span><i>B</i></span><i>rucella abortus</i> is highly conserved among the α‐proteobacteria Open
Summary Small RNAs are principal elements of bacterial gene regulation and physiology. Two small RNAs in B rucella abortus , Abc R 1 and Abc R 2, are required for wild‐type virulence. Examination of the abc R loci revealed the presence of …
View article: Coordinated Zinc Homeostasis Is Essential for the Wild-Type Virulence of Brucella abortus
Coordinated Zinc Homeostasis Is Essential for the Wild-Type Virulence of Brucella abortus Open
Metal homeostasis in bacterial cells is a highly regulated process requiring intricately coordinated import and export, as well as precise sensing of intracellular metal concentrations. The uptake of zinc (Zn) has been linked to the virule…