Laurence Bianchini
YOU?
Author Swipe
View article: A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging
A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging Open
View article: Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
The supplemental figure 12 describes EGR1 expression during cell dedifferentiation. The supplemental figure 13 descries miR-199a-3p conserved sites in EGR1 3'UTR. The supplemental figure 14 describes the effects of shEGR1 and synthetic miR…
View article: figure legends and tables from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
figure legends and tables from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
this text corresponds to the legends of supplemental tables 1 to 3 and supplemental figures 1 to 14
View article: Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
There is great interest in understanding how the cancer stem cell population may be maintained in solid tumors. Here, we show that tumor cells exhibiting stem-like properties and expression of pluripotency markers NANOG and OCT4 can arise …
View article: Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
This figure describes EGR1, OLIG2, KI67 and GFAP expression in mitotic and not-mitotic GBM territories.
View article: Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
This figure describes EGR1, OLIG2, KI67 and GFAP expression in mitotic and not-mitotic GBM territories.
View article: Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
These figures describe that : dedifferentiation restores stem-like and tumorigenic properties (sup fig 5); EGFR and ERK inhibitions on the dedifferentiation process (sup fig 6 and 7).
View article: Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
The supplemental figure 10 describes the acquisition of pluripotency markers by tumor cells freshly dissociated from tumors at a single cell level. The supplemental figure 11 shows the ability of EGF, PDGF, bFGF to induce or not the dediff…
View article: figure legends and tables from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
figure legends and tables from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
this text corresponds to the legends of supplemental tables 1 to 3 and supplemental figures 1 to 14
View article: Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
These figures describe that : dedifferentiation restores stem-like and tumorigenic properties (sup fig 5); EGFR and ERK inhibitions on the dedifferentiation process (sup fig 6 and 7).
View article: Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
These figures describe the identification of three clusters of genes that are regulated by ERK upon EGF-mediated dedifferentiation (sup fig 8) and the probability of survival of patients expressing these clusters at a level above or below …
View article: Supplementary tables S1-S3 from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Supplementary tables S1-S3 from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
tables describing OCT4 and NANOG positive cells (sup table S1); tables describing gene clustering and GEO (sup tables S2 and S3)
View article: Supplementary tables S1-S3 from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Supplementary tables S1-S3 from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
tables describing OCT4 and NANOG positive cells (sup table S1); tables describing gene clustering and GEO (sup tables S2 and S3)
View article: Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
The supplemental figure 12 describes EGR1 expression during cell dedifferentiation. The supplemental figure 13 descries miR-199a-3p conserved sites in EGR1 3'UTR. The supplemental figure 14 describes the effects of shEGR1 and synthetic miR…
View article: Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
These figures describe egfr expression and amplification in the original tumors and patient-derived GSC (sup fig 1); spheroid formation (sup fig 2); magnification of figure 1b (sup fig 3), stem-like and tumorigenic properties of the result…
View article: Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
There is great interest in understanding how the cancer stem cell population may be maintained in solid tumors. Here, we show that tumor cells exhibiting stem-like properties and expression of pluripotency markers NANOG and OCT4 can arise …
View article: Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
These figures describe egfr expression and amplification in the original tumors and patient-derived GSC (sup fig 1); spheroid formation (sup fig 2); magnification of figure 1b (sup fig 3), stem-like and tumorigenic properties of the result…
View article: Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
The supplemental figure 10 describes the acquisition of pluripotency markers by tumor cells freshly dissociated from tumors at a single cell level. The supplemental figure 11 shows the ability of EGF, PDGF, bFGF to induce or not the dediff…
View article: Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells
Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells Open
These figures describe the identification of three clusters of genes that are regulated by ERK upon EGF-mediated dedifferentiation (sup fig 8) and the probability of survival of patients expressing these clusters at a level above or below …
View article: High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies
High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies Open
This work was partly founded by a grant from La Ligue.
View article: Novel Therapeutic Insights in Dedifferentiated Liposarcoma: A Role for FGFR and MDM2 Dual Targeting
Novel Therapeutic Insights in Dedifferentiated Liposarcoma: A Role for FGFR and MDM2 Dual Targeting Open
We aimed to evaluate the therapeutic potential of the pan-FGFR inhibitor erdafitinib to treat dedifferentiated liposarcoma (DDLPS). FGFR expression and their prognostic value were assessed in a series of 694 samples of well-differentiated/…
View article: Double minute chromosomes harboring MDM2 amplification in a pediatric atypical lipomatous tumor
Double minute chromosomes harboring MDM2 amplification in a pediatric atypical lipomatous tumor Open
International audience
View article: The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer
The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer Open
Neocentromeres contribute to cancer progression by mitotically stabilizing acentric chromosomes containing amplified oncogenes. Macchia et al. show that... Genome amplification in the form of rings or giant rod-shaped marker chromosomes (R…
View article: Soft Tissues: Ordinary lipoma with t(1;12)(p32;q14) HMGA2/PPAP2B
Soft Tissues: Ordinary lipoma with t(1;12)(p32;q14) HMGA2/PPAP2B Open
View article: SREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte Differentiation
SREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte Differentiation Open
White adipose tissue (WAT) is essential for maintaining metabolic function, especially during obesity. The intronic microRNAs miR-33a and miR-33b, located within the genes encoding sterol regulatory element-binding protein 2 (SREBP-2) and …
View article: Prognostic value of HMGA2, CDK4, and JUN amplification in well-differentiated and dedifferentiated liposarcomas
Prognostic value of HMGA2, CDK4, and JUN amplification in well-differentiated and dedifferentiated liposarcomas Open