Laurence Charles
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View article: Acceleration, simplification and potential parallelization of digital polymers sequencing by coupling tandem mass spectrometry with ion mobility
Acceleration, simplification and potential parallelization of digital polymers sequencing by coupling tandem mass spectrometry with ion mobility Open
Tailoring the structure of digital polymers is an efficient strategy for reliable reading of large amounts of data by tandem mass spectrometry. Notably, full sequence coverage of chains containing up to 33 bytes of information is achieved …
View article: Editorial—In Memory of Jean‐François Muller
Editorial—In Memory of Jean‐François Muller Open
View article: Evaluation of Various Thiourea Derivatives as Reducing Agents in Two-Component Methacrylate-Based Materials
Evaluation of Various Thiourea Derivatives as Reducing Agents in Two-Component Methacrylate-Based Materials Open
Two-component dental materials are commonly used by the dentist for various applications (cementation of indirect restorations, filling of a cavity without layering, etc.). These materials are cured by redox polymerization. The (hydro)pero…
View article: A Special Issue Dedicated to the Outstanding Scientific Career of Prof. Chrys Wesdemiotis
A Special Issue Dedicated to the Outstanding Scientific Career of Prof. Chrys Wesdemiotis Open
View article: Conception and Synthesis of Sequence‐Coded Morpholinos
Conception and Synthesis of Sequence‐Coded Morpholinos Open
Solid‐phase morpholino chemistry was explored as a new route to synthesize abiological sequence‐defined oligomers. Two comonomers, 0 and 1 containing (i) a chlorophosphoramidate reactive function, (ii) a trityl‐protected morpholine, and (i…
View article: Molecular Stiffening by Macrocycle Clustering
Molecular Stiffening by Macrocycle Clustering Open
Allosteric stiffening of a portion of a protein surface is a strategy used in nature to regulate protein oligomerization and provide crucial functions for cells. However, a similar strategy to selectively control part of a compound dynamic…
View article: Molecular Stiffening by Macrocycle Clustering
Molecular Stiffening by Macrocycle Clustering Open
Allosteric stiffening of a portion of a protein surface is a strategy used in nature to regulate protein oligomerization and provide crucial functions for cells. However, a similar strategy to selectively control part of a compound dynamic…
View article: Combining Laser‐Induced Edition to Collision‐Induced Sequencing of Digital Oligomers in a Single Gas‐Phase Experiment
Combining Laser‐Induced Edition to Collision‐Induced Sequencing of Digital Oligomers in a Single Gas‐Phase Experiment Open
Rationale To increase the confidentiality level of molecular tags, binary information can be hidden in sequence‐defined oligomers using isobaric monomers including a photo‐sensitive one, which mass can be modified upon light irradiation. R…
View article: Photo‐Accelerated Synthesis of Oligo(triazole amide)s
Photo‐Accelerated Synthesis of Oligo(triazole amide)s Open
A photo‐assisted process is explored for improving the synthesis of oligo(triazole amide)s, which are prepared by solid phase synthesis using a repeated cycle of two reactions: amine‐carboxylic acid coupling and copper‐catalyzed azide‐alky…
View article: α‐Trifluoromethylated Quinolines as Safe and Storable PET‐Donor for Radical Polymerizations.
α‐Trifluoromethylated Quinolines as Safe and Storable PET‐Donor for Radical Polymerizations. Open
In the quest for powerful, safe, and storable photoinduced‐electron transfer (PET) donors, the attention is turned to the α‐trihalomethylated amine moiety that is not studied in the context of PET‐reductants. The thermal and photophysical …
View article: Complex Sequence‐Defined Heteropolymers Enable Controlled Film Growth in Layer‐By‐Layer Assembly
Complex Sequence‐Defined Heteropolymers Enable Controlled Film Growth in Layer‐By‐Layer Assembly Open
Digitally‐encoded poly(phosphodiesters) ( d ‐PPDE) with highly complex primary structures are evaluated for layer‐by‐layer (LbL) assembly. To be easily decoded by mass spectrometry (MS), these digital polymers contain many different monome…
View article: Degradation strategies for structural characterization of insoluble synthetic polymers by mass spectrometry
Degradation strategies for structural characterization of insoluble synthetic polymers by mass spectrometry Open
With the advent of soft ionization techniques such as electrospray (ESI) and matrix‐assisted laser desorption/ionization (MALDI) to produce intact gas‐phase ions from nonvolatile macromolecules, mass spectrometry has become an essential te…
View article: Using ion mobility spectrometry to understand signal dilution during tandem mass spectrometry sequencing of digital polymers: Experimental evidence of intramolecular cyclization
Using ion mobility spectrometry to understand signal dilution during tandem mass spectrometry sequencing of digital polymers: Experimental evidence of intramolecular cyclization Open
Rationale Optimizing the structure of digital polymers is an efficient strategy to ensure their tandem mass spectrometry (MS/MS) readability. In block‐truncated poly(phosphodiester)s, homolysis of C–ON bonds in long chains permits the rele…
View article: Mass spectrometry of dendrimers
Mass spectrometry of dendrimers Open
Mass spectrometry (MS) has become an essential technique to characterize dendrimers as it proved efficient at tackling analytical challenges raised by their peculiar onion‐like structure. Owing to their chemical diversity, this review cove…
View article: Desorption electrospray ionization mass spectrometry imaging of latent fingerprints revealed by Oil Red O
Desorption electrospray ionization mass spectrometry imaging of latent fingerprints revealed by Oil Red O Open
Mass spectrometry imaging (MSI) is increasingly used to produce chemical images of latent fingerprints. Yet, the actual benefits of MSI for real case studies have to be assessed for fingerprints previously processed by forensic techniques.…
View article: Using Nitroxides To Model the Ion Mobility Behavior of Nitroxide-Ended Oligomers: A Bottom-up Approach To Predict Mobility Separation
Using Nitroxides To Model the Ion Mobility Behavior of Nitroxide-Ended Oligomers: A Bottom-up Approach To Predict Mobility Separation Open
Block-truncated poly(phosphodiester)s are digital macromolecules storing binary information that can be decoded by MS/MS sequencing of individual blocks released as primary fragments of the entire polymer. As such, they are ideal species f…
View article: CCDC 2182217: Experimental Crystal Structure Determination
CCDC 2182217: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Internal Dynamics and Modular Peripheral Binding in Stimuli‐Responsive 3 : 2 Host:Guest Complexes
Internal Dynamics and Modular Peripheral Binding in Stimuli‐Responsive 3 : 2 Host:Guest Complexes Open
Now that the chemistry of 1 : 1 host:guest complexes is well‐established, it is surprising to note that higher stoichiometry (oligomeric) complexes, especially those with excess host, remain largely unexplored. Yet, proteins tend to oligom…
View article: Internal Dynamics and Modular Peripheral Binding in Stimuli‐Responsive 3 : 2 Host:Guest Complexes
Internal Dynamics and Modular Peripheral Binding in Stimuli‐Responsive 3 : 2 Host:Guest Complexes Open
Now that the chemistry of 1 : 1 host:guest complexes is well‐established, it is surprising to note that higher stoichiometry (oligomeric) complexes, especially those with excess host, remain largely unexplored. Yet, proteins tend to oligom…
View article: Informational Polymers with Precise Carbamate Sequences
Informational Polymers with Precise Carbamate Sequences Open
Sequence-defined oligocarbamates were synthesized by orthogonal iterative chemistry on a modified Wang solid support. In this approach, amino alcohol building blocks, containing either primary or secondary amines, were used in order to obt…
View article: Conception and Evaluation of a Library of Cleavable Mass Tags for Digital Polymers Sequencing
Conception and Evaluation of a Library of Cleavable Mass Tags for Digital Polymers Sequencing Open
A library of phosphoramidite monomers containing a main‐chain cleavable alkoxyamine and a side‐chain substituent of variable molar mass (i.e. mass tag) was prepared in this work. These monomers can be used in automated solid‐phase phosphor…
View article: Conception and Evaluation of a Library of Cleavable Mass Tags for Digital Polymers Sequencing
Conception and Evaluation of a Library of Cleavable Mass Tags for Digital Polymers Sequencing Open
A library of phosphoramidite monomers containing a main‐chain cleavable alkoxyamine and a side‐chain substituent of variable molar mass (i.e. mass tag) was prepared in this work. These monomers can be used in automated solid‐phase phosphor…
View article: The IMSCal approach to determine collision cross section of multiply charged anions in traveling wave ion mobility spectrometry
The IMSCal approach to determine collision cross section of multiply charged anions in traveling wave ion mobility spectrometry Open
View article: Preparation and <i>In Vitro</i> Validation of a Cucurbit[7]uril-Peptide Conjugate Targeting the LDL Receptor
Preparation and <i>In Vitro</i> Validation of a Cucurbit[7]uril-Peptide Conjugate Targeting the LDL Receptor Open
Here we report the coupling of a cyclic peptide (VH4127) targeting the low density lipoprotein (LDL) receptor (LDLR) noncompetitively to cucurbit[7]uril (CB[7]) to develop a new kind of drug delivery system (DDS), namely, CB[7]-VH41…
View article: Sequential Formation of Heteroternary Cucurbit[10]uril (CB[10]) Complexes
Sequential Formation of Heteroternary Cucurbit[10]uril (CB[10]) Complexes Open
The globular and monocationic guest molecule trimethyl‐azaphosphatrane ( AZAP , a protonated Verkade superbase) was shown to form a host:guest 1 : 1 complex with the cucurbit[10]uril (CB[10]) macrocycle in water. Molecular dynamics calcula…
View article: Covalent Attachment and Detachment by Reactive DESI of Sequence‐Coded Polymer Taggants
Covalent Attachment and Detachment by Reactive DESI of Sequence‐Coded Polymer Taggants Open
The use of sequence‐defined polymers is an interesting emerging solution for materials identification and traceability. Indeed, a very large amount of identification sequences can be created using a limited alphabet of coded monomers. Howe…
View article: Multi‐catalytic Enantioselective Synthesis of 1,3‐Diols Containing a Tetrasubstituted Fluorinated Stereocenter
Multi‐catalytic Enantioselective Synthesis of 1,3‐Diols Containing a Tetrasubstituted Fluorinated Stereocenter Open
View article: CCDC 2084853: Experimental Crystal Structure Determination
CCDC 2084853: Experimental Crystal Structure Determination Open
View article: Enantiocontrol over Acyclic Quaternary Stereocenters by Acylative Organocatalyzed Kinetic Resolution
Enantiocontrol over Acyclic Quaternary Stereocenters by Acylative Organocatalyzed Kinetic Resolution Open
View article: Enantiocontrol over Acyclic Quaternary Stereocenters by Acylative Organocatalyzed Kinetic Resolution
Enantiocontrol over Acyclic Quaternary Stereocenters by Acylative Organocatalyzed Kinetic Resolution Open
In the present paper, we described the efficient enantioselective kinetic resolution (KR) of racemic diastereocontrolled secondary alcohols bearing a quaternary stereocenter using a commercially available chiral isothiourea organocatalyst.…