Laurence Dewachter
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View article: Cascading renal injury after brain death: Unveiling glycocalyx alteration and the potential protective role of tacrolimus
Cascading renal injury after brain death: Unveiling glycocalyx alteration and the potential protective role of tacrolimus Open
Brain death (BD) is a complex medical state that triggers systemic disturbances and a cascade of pathophysiological processes. This condition significantly impairs both kidney function and structural integrity, thereby presenting considera…
View article: Inhibition of circulating dipeptidyl-peptidase 3 by procizumab in experimental septic shock reduces catecholamine exposure and myocardial injury
Inhibition of circulating dipeptidyl-peptidase 3 by procizumab in experimental septic shock reduces catecholamine exposure and myocardial injury Open
View article: Early Alteration of Right Ventricle–Pulmonary Artery Coupling in Experimental Heart Failure With Preserved Ejection Fraction
Early Alteration of Right Ventricle–Pulmonary Artery Coupling in Experimental Heart Failure With Preserved Ejection Fraction Open
Background Pulmonary hypertension and right ventricular (RV) dysfunction are major prognostic determinants in patients with heart failure with preserved ejection fraction (HFpEF). The underlying pathomechanisms remain unknown. In this cont…
View article: Neutralization of extracellular histones by sodium-Β-O-methyl cellobioside sulfate in septic shock
Neutralization of extracellular histones by sodium-Β-O-methyl cellobioside sulfate in septic shock Open
View article: Beneficial Effects of Tacrolimus on Brain-Death-Associated Right Ventricular Dysfunction in Pigs
Beneficial Effects of Tacrolimus on Brain-Death-Associated Right Ventricular Dysfunction in Pigs Open
Background: Right ventricular (RV) dysfunction remains a major problem after heart transplantation and may be associated with brain death (BD) in a donor. A calcineurin inhibitor tacrolimus was recently found to have beneficial effects on …
View article: Pediatric pulmonary arterial hypertension due to a novel homozygous <scp><i>GDF2</i></scp> missense variant affecting <scp>BMP9</scp> processing and activity
Pediatric pulmonary arterial hypertension due to a novel homozygous <span><i>GDF2</i></span> missense variant affecting <span>BMP9</span> processing and activity Open
Pulmonary arterial hypertension (PAH) is a rare and severe disorder characterized by progressive pulmonary vasculopathy. Growth differentiation factor ( GDF ) 2 encodes the pro‐protein bone morphogenetic protein (BMP) 9, activated after cl…
View article: Angiotensin 1–7 in an experimental septic shock model
Angiotensin 1–7 in an experimental septic shock model Open
View article: Prostacyclin receptor agonists induce DUSP1 to inhibit pulmonary artery smooth muscle cell proliferation
Prostacyclin receptor agonists induce DUSP1 to inhibit pulmonary artery smooth muscle cell proliferation Open
View article: Altered Left Ventricular Rat Gene Expression Induced by the Myosin Activator Omecamtiv Mecarbil
Altered Left Ventricular Rat Gene Expression Induced by the Myosin Activator Omecamtiv Mecarbil Open
To explore the impact of omecamtiv mecarbil (OM) on the gene expression profile in adult male rats. Fourteen male Wistar rats were randomly assigned to a single OM (1.2 mg/kg/h; n = 6) or placebo (n = 8) 30-min infusion. Echocardiography w…
View article: Detection of soluble suppression of tumorigenicity 2 and N-terminal B-type natriuretic peptide in a rat model of aortic regurgitation: differential responses to omecamtiv mecarbil
Detection of soluble suppression of tumorigenicity 2 and N-terminal B-type natriuretic peptide in a rat model of aortic regurgitation: differential responses to omecamtiv mecarbil Open
Objectives Both N-terminal fragment of B-type natriuretic peptide (NT-proBNP) and soluble isoform of ST2 (sST2) have been identified as biomarkers of heart failure. We evaluated the plasma levels of NT-proBNP and sST2 in a rat model of sev…
View article: Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock
Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock Open
Background Angiotensin II is one of the vasopressors available for use in septic shock. However, its effects on the septic myocardium remain unclear. The aim of the study was to compare the effects of angiotensin II and norepinephrine on c…
View article: Tacrolimus Prevents Mechanical and Humoral Alterations in Brain Death–induced Lung Injury in Pigs
Tacrolimus Prevents Mechanical and Humoral Alterations in Brain Death–induced Lung Injury in Pigs Open
Rationale: Donor brain death-induced lung injury may compromise graft function after transplantation. Establishing strategies to attenuate lung damage remains a challenge because the underlying mechanisms remain uncertain. Object…
View article: Effects of Tacrolimus on Mechanical and Humoral Determinants of Brain Death-Induced Lung Injury
Effects of Tacrolimus on Mechanical and Humoral Determinants of Brain Death-Induced Lung Injury Open
View article: A Preclinical Rat Model of Heart Failure With Preserved Ejection Fraction With Multiple Comorbidities
A Preclinical Rat Model of Heart Failure With Preserved Ejection Fraction With Multiple Comorbidities Open
Heart failure with preserved ejection fraction (HFpEF) is a common complex clinical syndrome for which there are currently few evidence-based therapies. As patients with HFpEF very often present with comorbidities comprising the metabolic …
View article: Prostacyclin Receptor Agonists Induce DUSP1 to Inhibit Pulmonary Artery Smooth Muscle Cell Proliferation
Prostacyclin Receptor Agonists Induce DUSP1 to Inhibit Pulmonary Artery Smooth Muscle Cell Proliferation Open
View article: Early Hyperdynamic Sepsis Alters Coronary Blood Flow Regulation in Porcine Fecal Peritonitis
Early Hyperdynamic Sepsis Alters Coronary Blood Flow Regulation in Porcine Fecal Peritonitis Open
Background: Sepsis is a common condition known to impair blood flow regulation and microcirculation, which can ultimately lead to organ dysfunction but such contribution of the coronary circulation remains to be clarified. We investigated …
View article: Acute effects of hypouricemia on endothelium, oxidative stress, and arterial stiffness: A randomized, double‐blind, crossover study
Acute effects of hypouricemia on endothelium, oxidative stress, and arterial stiffness: A randomized, double‐blind, crossover study Open
We hypothesized acute moderate and drastic reductions in uric acid concentration exert different effects on arterial function in healthy normotensive and hypertensive adults. Thirty-six adults (aged 58 [55;63] years) with or without primar…
View article: Hypoxia-induced Angiogenesis Rescues Survival from Small for Size Syndrome (SFSS)
Hypoxia-induced Angiogenesis Rescues Survival from Small for Size Syndrome (SFSS) Open
View article: Chemerin Added to Endothelin-1 Promotes Rat Pulmonary Artery Smooth Muscle Cell Proliferation and Migration
Chemerin Added to Endothelin-1 Promotes Rat Pulmonary Artery Smooth Muscle Cell Proliferation and Migration Open
Chemerin/CMKRL1 signaling, in conjunction with a key mediator in the pathogenesis of pulmonary hypertensive diseases, endothelin-1, stimulated proliferation and migration, and increased resistance to apoptosis in rat primary cultured pulmo…
View article: Endothelin-1 induces lysyl oxidase expression in pulmonary artery smooth muscle cells
Endothelin-1 induces lysyl oxidase expression in pulmonary artery smooth muscle cells Open
The increase in thickening of the arterial wall of pulmonary arterial hypertension (PAH) includes cellular proliferation as well as matrix deposition and interrupted internal elastic lamina (IEL) consisting of a thick homogeneous sheet of …
View article: An intact animal model for the assessment of coronary blood flow regulation “Coronary blood flow regulation”
An intact animal model for the assessment of coronary blood flow regulation “Coronary blood flow regulation” Open
Coronary blood flow adapts to metabolic demand ("metabolic regulation") and remains relatively constant over a range of pressure changes ("autoregulation"). Coronary metabolic regulation and autoregulation are usually studied separately. W…
View article: High fat diet altered cardiac metabolic gene profile in Psammomys obesus gerbils
High fat diet altered cardiac metabolic gene profile in Psammomys obesus gerbils Open
View article: Effects of Tacrolimus on Mechanical and Humoral Determinants of Brain Death-Induced Lung Injury in Piglets
Effects of Tacrolimus on Mechanical and Humoral Determinants of Brain Death-Induced Lung Injury in Piglets Open
View article: Chemerin influences endothelin- and serotonin-induced pulmonary artery vasoconstriction in rats
Chemerin influences endothelin- and serotonin-induced pulmonary artery vasoconstriction in rats Open
View article: Inflammation in Right Ventricular Failure: Does It Matter?
Inflammation in Right Ventricular Failure: Does It Matter? Open
Right ventricular (RV) failure is a common consequence of acute and chronic RV overload of pressure, such as after pulmonary embolism and pulmonary hypertension. It has been recently realized that symptomatology and survival of patients wi…
View article: Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases
Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases Open
The European Respiratory Society (ERS) Research Seminar entitled “Pulmonary vascular endothelium: orchestra conductor in respiratory diseases - highlights from basic research to therapy” brought together international experts in dysfunctio…
View article: P3523Pressure-flow relationship in the normal pulmonary circulation by exercise echocardiography: are measurements reproducible over time?
P3523Pressure-flow relationship in the normal pulmonary circulation by exercise echocardiography: are measurements reproducible over time? Open
View article: Mechanical versus humoral determinants of brain death-induced lung injury
Mechanical versus humoral determinants of brain death-induced lung injury Open
Brain death-induced lung injury may be best explained by an initial excessive increase in pulmonary capillary pressure with increased pulmonary venous resistance, and was associated with lung activation of inflammatory apoptotic processes …
View article: Influence of Donor Lung Surfactant-A and -B Protein Expression on the Development of Primary Graft Dysfunction After Lung Transplantation: A Pilot Study
Influence of Donor Lung Surfactant-A and -B Protein Expression on the Development of Primary Graft Dysfunction After Lung Transplantation: A Pilot Study Open
BACKGROUND Primary graft dysfunction (PGD) is responsible of high early mortality in lung transplanted patients. We measured the rate of surfactant proteins in the organ donor, and we observed the occurrence of lung PGD in the recipient. T…
View article: Leptin-Induced Endothelium-Independent Vasoconstriction in Thoracic Aorta and Pulmonary Artery of Spontaneously Hypertensive Rats: Role of Calcium Channels and Stores
Leptin-Induced Endothelium-Independent Vasoconstriction in Thoracic Aorta and Pulmonary Artery of Spontaneously Hypertensive Rats: Role of Calcium Channels and Stores Open
Decreased leptin-induced endothelium-dependent vasodilation has been reported in spontaneously hypertensive rats (SHR). Here, we report leptin-induced vasoconstriction in endothelium-denuded pulmonary artery and thoracic aorta from SHR and…