Laurence Dubourg
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View article: Descriptive cohort study of transient isolated tubular acidosis in early childhood: experience from a rare kidney disease expert center
Descriptive cohort study of transient isolated tubular acidosis in early childhood: experience from a rare kidney disease expert center Open
Growth faltering and/or failure to thrive in children often prompts metabolic assessment, sometimes revealing metabolic acidosis and leading to referral to pediatric nephrology. Renal tubular acidosis (RTA), causing hyperchloremic metaboli…
View article: Enhancing individual glomerular filtration rate assessment: can we trust the equation? Development and validation of machine learning models to assess the trustworthiness of estimated GFR compared to measured GFR
Enhancing individual glomerular filtration rate assessment: can we trust the equation? Development and validation of machine learning models to assess the trustworthiness of estimated GFR compared to measured GFR Open
View article: Improving the diagnostic of absorptive hypercalciuria: a comparative analysis of calcium load tests at 2-hour and 4-hour intervals
Improving the diagnostic of absorptive hypercalciuria: a comparative analysis of calcium load tests at 2-hour and 4-hour intervals Open
Introduction The calcium load test (CLT) was developed by Pak et al. in 1974 to better discriminate hypercalciuria. Absorptive hypercalciuria (AH) is defined by an increase of the difference between urinary calcium/creatinine ratio (ΔUCa/C…
View article: Extending the Lund-Malmö creatinine-based GFR equation to cystatin C – validation results from the European Kidney Function Consortium (EKFC) cohort of children and adults
Extending the Lund-Malmö creatinine-based GFR equation to cystatin C – validation results from the European Kidney Function Consortium (EKFC) cohort of children and adults Open
The aim of the present study was to extend the creatinine-based Lund-Malmö GFR equation for use with rescaled cystatin C (r-LMRCys) and validate it against measured GFR (mGFR) in the EKFC cystatin C cohort of children (n …
View article: Correction: Stämmler et al. Estimating Glomerular Filtration Rate from Serum Myo-Inositol, Valine, Creatinine and Cystatin C. Diagnostics 2021, 11, 2291
Correction: Stämmler et al. Estimating Glomerular Filtration Rate from Serum Myo-Inositol, Valine, Creatinine and Cystatin C. Diagnostics 2021, 11, 2291 Open
In the original publication [...]
View article: The<scp>EKFC</scp>equation outperforms the<scp>CKD</scp>‐<scp>EPI</scp>and<scp>CKiD</scp>equations for<scp>GFR</scp>estimation in adolescent and young adult kidney transplant patients
The<span>EKFC</span>equation outperforms the<span>CKD</span>‐<span>EPI</span>and<span>CKiD</span>equations for<span>GFR</span>estimation in adolescent and young adult kidney transplant patients Open
Aim This study evaluated the bias and accuracy of the CKD‐EPI/CKiD and EKFC equations compared with the reference exogenous tracer‐based assessment of glomerular filtration rate (GFR) in adult and pediatric patients according to their rena…
View article: Hypomagnesaemia with varying degrees of extrarenal symptoms as a consequence of heterozygous CNNM2 variants
Hypomagnesaemia with varying degrees of extrarenal symptoms as a consequence of heterozygous CNNM2 variants Open
View article: Renal toxicity of ifosfamide in children with cancer: an exploratory study integrating aldehyde dehydrogenase enzymatic activity data and a wide-array urinary metabolomics approach
Renal toxicity of ifosfamide in children with cancer: an exploratory study integrating aldehyde dehydrogenase enzymatic activity data and a wide-array urinary metabolomics approach Open
View article: Cystatin C as a marker of renal function in patients with chronic intestinal failure on long-term parenteral nutrition
Cystatin C as a marker of renal function in patients with chronic intestinal failure on long-term parenteral nutrition Open
View article: #5465 RACE-FREE EGFR EQUATION IN KIDNEY RECIPIENTS: A DEVELOPMENT AND VALIDATION STUDY
#5465 RACE-FREE EGFR EQUATION IN KIDNEY RECIPIENTS: A DEVELOPMENT AND VALIDATION STUDY Open
Background and Aims To assess the performances of the current eGFR equations, including the race-free CKD-EPI-2021, in the kidney transplant population, and compare these performances to a race-free kidney-recipient-specific (KRS) GFR equa…
View article: Race-free estimated glomerular filtration rate equation in kidney transplant recipients: development and validation study
Race-free estimated glomerular filtration rate equation in kidney transplant recipients: development and validation study Open
Objective To compare the performance of a newly developed race-free kidney recipient specific glomerular filtration rate (GFR) equation with the three current main equations for measuring GFR in kidney transplant recipients. Design Develop…
View article: Cystatin C–Based Equation to Estimate GFR without the Inclusion of Race and Sex
Cystatin C–Based Equation to Estimate GFR without the Inclusion of Race and Sex Open
The EKFC eGFRcys equation had the same mathematical form as the EKFC eGFRcr equation, but it had a scaling factor for cystatin C that did not differ according to race or sex. In cohorts from Europe, the United States, and Africa, this equa…
View article: Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa
Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa Open
Background A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This equation has neither been validated outside USA nor compared with the new European Kidney Fu…
View article: Standardization of serum creatinine is essential for accurate use of unbiased estimated GFR equations: evidence from three cohorts matched on renal function
Standardization of serum creatinine is essential for accurate use of unbiased estimated GFR equations: evidence from three cohorts matched on renal function Open
Background Differences in the performance of estimated glomerular filtration rate (eGFR) equations have been attributed to the mathematical form of the equations and to differences between patient demographics and measurement methods. We e…
View article: Point of care creatinine derived eGFR measurement in capillary blood for identifying patients at risk
Point of care creatinine derived eGFR measurement in capillary blood for identifying patients at risk Open
The use of a handheld blood creatinine monitoring system with eGFR calculation provides a good estimation of GFR and allow to identify patients at high risk of acute kidney injury.
View article: Fluconazole in hypercalciuric patients with increased 1,25(OH)2D levels: the prospective, randomized, placebo-controlled, double-blind FLUCOLITH trial
Fluconazole in hypercalciuric patients with increased 1,25(OH)2D levels: the prospective, randomized, placebo-controlled, double-blind FLUCOLITH trial Open
Background Hypercalciuria is one of the most frequent metabolic disorders associated with nephrolithiasis and/or nephrocalcinosis possibly leading to chronic kidney disease (CKD) and bone complications in adults. Orphan diseases with diffe…
View article: Prediction Tool to Estimate Potassium Diet in Chronic Kidney Disease Patients Developed Using a Machine Learning Tool: The UniverSel Study
Prediction Tool to Estimate Potassium Diet in Chronic Kidney Disease Patients Developed Using a Machine Learning Tool: The UniverSel Study Open
There is a need for a reliable and validated method to estimate dietary potassium intake in chronic kidney disease (CKD) patients to improve prevention of cardiovascular complications. This study aimed to develop a clinical tool to estimat…
View article: MO385: Performance of Creatinine-Based Equations to Estimate Glomerular Filtration Rate in White and Black Subjects From Europe, Brazil and Africa
MO385: Performance of Creatinine-Based Equations to Estimate Glomerular Filtration Rate in White and Black Subjects From Europe, Brazil and Africa Open
BACKGROUND AND AIMS Current Glomerular filtration rate (GFR) estimating equations based on serum creatinine are facing increased criticism due to the inclusion of a race correction in black Americans with the CKD-EPI equation (CKD-EPIASR, …
View article: The Modified CKiD Study Estimated GFR Equations for Children and Young Adults Under 25 Years of Age: Performance in a European Multicenter Cohort
The Modified CKiD Study Estimated GFR Equations for Children and Young Adults Under 25 Years of Age: Performance in a European Multicenter Cohort Open
View article: Caractérisation fonctionnelle de sept variations faux-sens dans le gène du récepteur sensible au calcium (CASR)
Caractérisation fonctionnelle de sept variations faux-sens dans le gène du récepteur sensible au calcium (CASR) Open
View article: Fluconazole in Hypercalciuric Patients with Increased 1,25(OH)2D Levels: The Prospective, Randomized, Placebo-Controlled, Double Blind FLUCOLITH Trial.
Fluconazole in Hypercalciuric Patients with Increased 1,25(OH)2D Levels: The Prospective, Randomized, Placebo-Controlled, Double Blind FLUCOLITH Trial. Open
BackgroundHypercalciuria is one of the most frequent metabolic disorders associated with nephrolithiasis and/or nephrocalcinosis possibly leading to chronic kidney disease (CKD) and bone complications in adults. Orphan diseases with differ…
View article: Performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance
Performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance Open
Introduction: The guidelines recommend estimating the glomerular filtration rate using serum creatinine-based equations as a predictor of kidney disease, preferably adjusted for local population groups. Methods: Cross-sectional study that …
View article: Estimating Glomerular Filtration Rate from Serum Myo-Inositol, Valine, Creatinine and Cystatin C
Estimating Glomerular Filtration Rate from Serum Myo-Inositol, Valine, Creatinine and Cystatin C Open
Assessment of renal function relies on the estimation of the glomerular filtration rate (eGFR). Existing eGFR equations, usually based on serum levels of creatinine and/or cystatin C, are not uniformly accurate across patient populations. …
View article: Performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance
Performance of creatinine-based equations for estimating glomerular filtration rate compared to endogenous creatinine clearance Open
Introduction: The guidelines recommend estimating the glomerular filtration rate using serum creatinine-based equations as a predictor of kidney disease, preferably adjusted for local population groups. Methods: Cross-sectional study that …
View article: Performance of creatinine‐based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment
Performance of creatinine‐based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment Open
Aim The Cockcroft‐Gault (CG) creatinine‐based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over‐ or underdosing. Methods In a cross‐sectional analysis…
View article: Age-adapted percentiles of measured glomerular filtration in healthy individuals: extrapolation to living kidney donors over 65 years
Age-adapted percentiles of measured glomerular filtration in healthy individuals: extrapolation to living kidney donors over 65 years Open
Objectives Most data on glomerular filtration rate (GFR) originate from subjects <65 years old, complicating decision-making in elderly living kidney donors. In this retrospective multi-center study, we calculated percentiles of measured G…
View article: Iohexol Plasma Clearance: Impact of Weighing the Syringe
Iohexol Plasma Clearance: Impact of Weighing the Syringe Open
View article: Comparison of Plasma Clearance With Early-Compartment Correction Equations and Urinary Clearance in High GFR Ranges
Comparison of Plasma Clearance With Early-Compartment Correction Equations and Urinary Clearance in High GFR Ranges Open
View article: Combined use of creatinine and cystatin C improves the detection of renal dysfunction in children undergoing home parenteral nutrition
Combined use of creatinine and cystatin C improves the detection of renal dysfunction in children undergoing home parenteral nutrition Open
Background Renal dysfunction can complicate home parenteral nutrition (HPN). The aims were, in the context of pediatric HPN, to assess renal function using the measured glomerular filtration rate (mGFR), determine the most accurate formula…
View article: Composition of Urinary Stones in Children: Clinical and Metabolic Determinants in a French Tertiary Care Center
Composition of Urinary Stones in Children: Clinical and Metabolic Determinants in a French Tertiary Care Center Open
The aim was to describe the composition of stones of pediatric patients, to illustrate current epidemiological trends in pediatric urolithiasis.Clinical and metabolic data from all pediatric patients with at least one stone that was analyz…