Laurent Carrez
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View article: Assessment of leachables in hospital pharmacy compounded topotecan conditioned in common off-label syringes for intravitreal use
Assessment of leachables in hospital pharmacy compounded topotecan conditioned in common off-label syringes for intravitreal use Open
Compounding drug products is a vital hospital pharmacy feature that requires safe and compatible primary packaging, particularly for prefilled syringes (PFSs). The off-label use of plastic syringes in batch compounding for intravitreal adm…
View article: Expert opinion on extrusion-based pharmaceutical 3D printing from the European Society of Hospital Pharmaceutical Technology (GERPAC)
Expert opinion on extrusion-based pharmaceutical 3D printing from the European Society of Hospital Pharmaceutical Technology (GERPAC) Open
Three-dimensional (3D) printing technologies have been applied to manufacture a variety of medicinal products. This emerging technology holds significant potential in pharmaceutical applications, offering innovative solutions for both pati…
View article: Excess volume addition method improves human resource efficiency and environmental sustainability of cytotoxic drug preparations
Excess volume addition method improves human resource efficiency and environmental sustainability of cytotoxic drug preparations Open
Introduction The increasing incidence of cancer entails a rising burden of cytotoxic drugs preparation. To improve the preparation process of cytotoxic drugs, specially designed half-filled bags with overfill capacity were manufactured and…
View article: Stability study of topotecan in ophthalmic prefilled syringes for intravitreal delivery
Stability study of topotecan in ophthalmic prefilled syringes for intravitreal delivery Open
This study demonstrated that TPT solutions at 20 µg/mL and 200 µg/mL conditioned in BBraun Omnifix syringes could be stored at 5±3°C for 12 months for safe and secure administration to patients.
View article: A critical opinion-based review of hospital pharmacy compounding with respect to the risk of leachable substances due to the off-label use of plastic primary packaging
A critical opinion-based review of hospital pharmacy compounding with respect to the risk of leachable substances due to the off-label use of plastic primary packaging Open
Hospital pharmacies play a unique role in healthcare by regularly compounding drug products (DPs) in response to hospital demands and practices, for example, drug shortages, to cater to frail and vulnerable patients with infectious, chroni…
View article: Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets
Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets Open
Pharmacy compounding, the art and science of preparing customized medications to meet individual patient needs, is in a verge of transformation. Traditional methods of compounding often involve manual and time-consuming processes, presenti…
View article: Recommendations on training objectives and staff qualification for the manual preparation of capsules in pharmacy
Recommendations on training objectives and staff qualification for the manual preparation of capsules in pharmacy Open
Training and certification of personnel in capsule preparation are essential procedures, overseen by the pharmacist who delegates these tasks. These procedures aim not only to ensure the efficacy and safety of operations but also to establ…
View article: Qualification and Performance Evaluation of an Automated System for Compounding Injectable Cytotoxic Drugs
Qualification and Performance Evaluation of an Automated System for Compounding Injectable Cytotoxic Drugs Open
Background Use of automated systems for the production of chemotherapy will increase in answer to hospitals’ needs to rationalise production. The aim of the study was to evaluate the performance of a PharmaHelp ® automated system for compo…
View article: 1ISG-004 Impact of a lean approach on the organisation of a chemotherapy production unit
1ISG-004 Impact of a lean approach on the organisation of a chemotherapy production unit Open
Background Our chemotherapy production unit decided to rethink its organisational strategy and to revise its production processes through lean methodology to meet growing activity, in the context budget constraints that limit the increase …
View article: INT-001 Impact of work overload on quality of preparations in chemotherapy
INT-001 Impact of work overload on quality of preparations in chemotherapy Open
Background Chemotherapy preparation units have to face an increasing activity with constant staff. Safety is therefore compromised. Purpose The purpose of our experiment was to measure the effect of a work overload on preparations, accura…