Laurent Giovangrandi
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View article: A wireless device for continuous measurement of brain parenchymal resistance tracks glymphatic function in humans
A wireless device for continuous measurement of brain parenchymal resistance tracks glymphatic function in humans Open
View article: The glymphatic system clears amyloid beta and tau from brain to plasma in humans
The glymphatic system clears amyloid beta and tau from brain to plasma in humans Open
Poor sleep is implicated in the development of Alzheimer’s disease (AD) pathology and cognitive impairment. Dysfunction of the glymphatic system has been proposed as a mechanistic link between sleep disruption and AD, and in animal models …
View article: Glymphatic flow resistance in humans measured by multifrequency impedance dispersion
Glymphatic flow resistance in humans measured by multifrequency impedance dispersion Open
Glymphatic function in animal models supports the clearance of brain proteins whose mis-aggregation is implicated in neurodegenerative conditions including Alzheimer’s and Parkinson’s disease. The measurement of glymphatic function in the …
View article: Glymphatic function maintains sleep‐sensitive cognitive performance and predicts overnight changes in plasma amyloid β in humans
Glymphatic function maintains sleep‐sensitive cognitive performance and predicts overnight changes in plasma amyloid β in humans Open
Background During sleep, the glymphatic system facilitates rapid exchange of fluid through brain tissues, clearing solutes, including amyloid β (Aβ), tau, and α synuclein that accumulate through the course of waking activity. Glymphatic cl…
View article: Noninvasive and remote measurement of sleep‐active glymphatic function in the human brain by dynamic impedance spectro‐tomography
Noninvasive and remote measurement of sleep‐active glymphatic function in the human brain by dynamic impedance spectro‐tomography Open
Background Perivascular glymphatic exchange contributes to the clearance of amyloid β, tau, and α synuclein primarily during sleep. Glymphatic function has been assessed in human populations solely through neuroimaging, including contrast‐…