Laurent Golé
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View article: Smart biosurface® technology for prostate cancer detection and risk stratification through CTC enumeration and biomarker expression profiling
Smart biosurface® technology for prostate cancer detection and risk stratification through CTC enumeration and biomarker expression profiling Open
View article: A comprehensive AI model development framework for consistent Gleason grading
A comprehensive AI model development framework for consistent Gleason grading Open
Background Artificial Intelligence(AI)-based solutions for Gleason grading hold promise for pathologists, while image quality inconsistency, continuous data integration needs, and limited generalizability hinder their adoption and scalabil…
View article: Quantitative image-based collagen structural features predict the reversibility of hepatitis C virus-induced liver fibrosis post antiviral therapies
Quantitative image-based collagen structural features predict the reversibility of hepatitis C virus-induced liver fibrosis post antiviral therapies Open
The novel targeted therapeutics for hepatitis C virus (HCV) in last decade solved most of the clinical needs for this disease. However, despite antiviral therapies resulting in sustained virologic response (SVR), a challenge remains where …
View article: Comprehensive AI Model Development for Gleason Grading:From Scanning, Cloud-based Annotation to Pathologist-AI Interaction
Comprehensive AI Model Development for Gleason Grading:From Scanning, Cloud-based Annotation to Pathologist-AI Interaction Open
AI-based solutions for automated Gleason grading have been developed to assist pathologists to make rapid and quantitative assessments, but the generalization across various scanners and updating AI models continuously using new annotated …
View article: Automatic DNA replication tract measurement to assess replication and repair dynamics at the single-molecule level
Automatic DNA replication tract measurement to assess replication and repair dynamics at the single-molecule level Open
Motivation DNA fibre assay has a potential application in genomic medicine, cancer and stem cell research at the single-molecule level. A major challenge for the clinical and research implementation of DNA fibre assays is the slow speed in…
View article: Comprehensive AI Model Development for Gleason Grading: From Scanning, Cloud-Based Annotation to Pathologist-AI Interaction
Comprehensive AI Model Development for Gleason Grading: From Scanning, Cloud-Based Annotation to Pathologist-AI Interaction Open
View article: Constructing and optimizing 3D atlases from 2D data with application to the developing mouse brain
Constructing and optimizing 3D atlases from 2D data with application to the developing mouse brain Open
3D imaging data necessitate 3D reference atlases for accurate quantitative interpretation. Existing computational methods to generate 3D atlases from 2D-derived atlases result in extensive artifacts, while manual curation approaches are la…
View article: Author response: Constructing and optimizing 3D atlases from 2D data with application to the developing mouse brain
Author response: Constructing and optimizing 3D atlases from 2D data with application to the developing mouse brain Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract 3D imaging data necessitate 3…
View article: Quantitative stain-free imaging and digital profiling of collagen structure reveal diverse survival of triple negative breast cancer patients
Quantitative stain-free imaging and digital profiling of collagen structure reveal diverse survival of triple negative breast cancer patients Open
View article: Constructing and Optimizing 3D Atlases From 2D Data With Application to the Developing Mouse Brain
Constructing and Optimizing 3D Atlases From 2D Data With Application to the Developing Mouse Brain Open
3D imaging data necessitate 3D reference atlases for accurate quantitative interpretation. Existing computational methods to generate 3D atlases from 2D-derived atlases result in extensive artifacts, while manual curation approaches are la…
View article: Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr‐/‐.Leiden Mice
Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr‐/‐.Leiden Mice Open
Concerns have been raised about whether preclinical models sufficiently mimic molecular disease processes observed in nonalcoholic steatohepatitis (NASH) patients, bringing into question their translational value in studies of therapeutic …
View article: Membrane tension controls adhesion positioning at the leading edge of cells
Membrane tension controls adhesion positioning at the leading edge of cells Open
Cell migration is dependent on adhesion dynamics and actin cytoskeleton remodeling at the leading edge. These events may be physically constrained by the plasma membrane. Here, we show that the mechanical signal produced by an increase in …
View article: OpenSegSPIM: a user-friendly segmentation tool for SPIM data
OpenSegSPIM: a user-friendly segmentation tool for SPIM data Open
Summary: OpenSegSPIM is an open access and user friendly 3D automatic quantitative analysis tool for Single Plane Illumination Microscopy data. The software is designed to extract, in a user-friendly way, quantitative relevant information …