Laurent M. Paardekooper
YOU?
Author Swipe
View article: Autoantibody subclass predominance is not driven by aberrant class switching or impaired B cell development
Autoantibody subclass predominance is not driven by aberrant class switching or impaired B cell development Open
View article: Autoantibody subclass predominance is not driven by aberrant class switching or impaired B cell development
Autoantibody subclass predominance is not driven by aberrant class switching or impaired B cell development Open
A subset of autoimmune diseases is characterized by predominant pathogenic IgG4 autoantibodies (IgG4-AIDs). Why IgG4 predominates in these disorders is unknown. We hypothesized that dysregulated B cell maturation or aberrant class switchin…
View article: Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α
Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α Open
Objective SSc is a complex disease characterized by vascular abnormalities and inflammation culminating in hypoxia and excessive fibrosis. Previously, we identified chemokine (C-X-C motif) ligand 4 (CXCL4) as a novel predictive biomarker i…
View article: Radical Stress Is More Cytotoxic in the Nucleus than in Other Organelles
Radical Stress Is More Cytotoxic in the Nucleus than in Other Organelles Open
Cells are exposed to reactive oxygen species (ROS) as a by-product of mitochondrial metabolism, especially under hypoxia. ROS are also enzymatically generated at the plasma membrane during inflammation. Radicals cause cellular damage leadi…
View article: Human Monocyte-Derived Dendritic Cells Produce Millimolar Concentrations of ROS in Phagosomes Per Second
Human Monocyte-Derived Dendritic Cells Produce Millimolar Concentrations of ROS in Phagosomes Per Second Open
Neutrophils kill ingested pathogens by the so-called oxidative burst, where reactive oxygen species (ROS) are produced in the lumen of phagosomes at very high rates (mM/s), although these rates can only be maintained for a short period (mi…
View article: Oxygen in the tumor microenvironment: effects on dendritic cell function
Oxygen in the tumor microenvironment: effects on dendritic cell function Open
Solid tumors grow at a high speed leading to insufficient blood supply to tumor cells. This makes the tumor hypoxic, resulting in the Warburg effect and an increased generation of reactive oxygen species (ROS). Hypoxia and ROS affect immun…
View article: Oxygen shapes the early immune response
Oxygen shapes the early immune response Open
View article: Hypoxia potentiates monocyte-derived dendritic cells for release of tumor necrosis factor α via MAP3K8
Hypoxia potentiates monocyte-derived dendritic cells for release of tumor necrosis factor α via MAP3K8 Open
Dendritic cells (DCs) constantly sample peripheral tissues for antigens, which are subsequently ingested to derive peptides for presentation to T cells in lymph nodes. To do so, DCs have to traverse many different tissues with varying oxyg…
View article: Ethylene, an early marker of systemic inflammation in humans
Ethylene, an early marker of systemic inflammation in humans Open
View article: VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release
VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release Open
View article: Actomyosin-dependent dynamic spatial patterns of cytoskeletal components drive mesoscale podosome organization
Actomyosin-dependent dynamic spatial patterns of cytoskeletal components drive mesoscale podosome organization Open
View article: Lipid peroxidation causes endosomal antigen release for cross-presentation
Lipid peroxidation causes endosomal antigen release for cross-presentation Open