Laurent Nguyen
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View article: Selection of isatuximab dosing regimen in pediatric patients with leukemia using population pharmacokinetics
Selection of isatuximab dosing regimen in pediatric patients with leukemia using population pharmacokinetics Open
The modeling and simulation strategies in this study support the previous selection of a 20-mg/kg dose for all age groups and enabled both de-risking of dose selection and the ability to pursue additional pediatric investigation of isatuxi…
View article: 474 Smart-FAT: an innovative and predictive screening model mimicking cross-talk between human sensory neurons and adipocyte progenitors
474 Smart-FAT: an innovative and predictive screening model mimicking cross-talk between human sensory neurons and adipocyte progenitors Open
View article: Upregulation of ELP3 in acinar cells during acute pancreatitis is dispensable for homeostasis, inflammation, regeneration, and cancer initiation
Upregulation of ELP3 in acinar cells during acute pancreatitis is dispensable for homeostasis, inflammation, regeneration, and cancer initiation Open
Pancreatitis, or inflammation of the pancreas, is a common gastrointestinal condition. While often acute and self-resolving, it can become chronic and promote pancreatic ductal adenocarcinoma (PDAC), the third deadliest cancer worldwide. P…
View article: How hunger guides new brain cells to their destination
How hunger guides new brain cells to their destination Open
Blood flow and a hormone called ghrelin help new neurons travel to where they are meant to be in the brain of adult mice.
View article: Phytochemical combinations of lichen Evernia prunastri (L.) Ach. reduce drug resistance to temozolomide but not to paclitaxel in vitro
Phytochemical combinations of lichen Evernia prunastri (L.) Ach. reduce drug resistance to temozolomide but not to paclitaxel in vitro Open
Introduction Temozolomide (TMZ) and Paclitaxel (PXT), crucial anti-cancer drugs for glioblastoma (GBM) and primary breast cancer (BC), respectively, face drug resistance. Therefore, we investigated the adjuvant potential of characterized e…
View article: Species-specific Rates of Fatty Acid Metabolism Set the Scale of Temporal Patterning of Corticogenesis through Protein Acetylation Dynamics
Species-specific Rates of Fatty Acid Metabolism Set the Scale of Temporal Patterning of Corticogenesis through Protein Acetylation Dynamics Open
Developmental processes display temporal differences across species, leading to divergence in organ size and composition. In the cerebral cortex, neurons of diverse identities are generated sequentially through a temporal patterning mechan…
View article: Cytoskeletal control in adult microglia is essential to restore neurodevelopmental synaptic and cognitive deficits
Cytoskeletal control in adult microglia is essential to restore neurodevelopmental synaptic and cognitive deficits Open
Synaptic dysfunction is a hallmark of neurodevelopmental disorders (NDDs), often linked to genes involved in cytoskeletal regulation. While the role of these genes has been extensively studied in neurons, microglial functions such as phago…
View article: An Elongator mouse model of ALS spotlights TDP-43 in the motor neuron nucleolus
An Elongator mouse model of ALS spotlights TDP-43 in the motor neuron nucleolus Open
View article: Cross-Species Extrapolation of Neonatal Fc Receptor (FcRn) Binding Affinity to Predict Monoclonal Antibody Pharmacokinetics in Humans Using Physiologically Based Pharmacokinetic Modeling (PBPK): Are We There Yet?
Cross-Species Extrapolation of Neonatal Fc Receptor (FcRn) Binding Affinity to Predict Monoclonal Antibody Pharmacokinetics in Humans Using Physiologically Based Pharmacokinetic Modeling (PBPK): Are We There Yet? Open
Physiologically based pharmacokinetic (PBPK) modeling is a useful tool during drug development due to its ability to extrapolate pharmacokinetics (PK) between species and populations. For monoclonal antibodies (mAbs), these models can be u…
View article: Ccp1 depletion disrupts network integration of hippocampal parvalbumin interneurons
Ccp1 depletion disrupts network integration of hippocampal parvalbumin interneurons Open
Post-translational modifications (PTMs) of microtubules (MTs) endow them with specific properties that are essential for key cellular functions, such as axonal transport. Polyglutamylation, a PTM that accumulates in long-lived MTs, has bee…
View article: Genetic Animal Models of Idiopathic Generalized Epilepsies: What Can We Learn from Them?
Genetic Animal Models of Idiopathic Generalized Epilepsies: What Can We Learn from Them? Open
The use of animal models of idiopathic generalized epilepsy (IGE) is of great importance in the field of epilepsy research, with IGE affecting more than 20 million people worldwide. IGEs are characterized by a high degree of genetic hetero…
View article: SARS-CoV2 infection triggers inflammatory conditions and astrogliosis-related gene expression in long-term human cortical organoids
SARS-CoV2 infection triggers inflammatory conditions and astrogliosis-related gene expression in long-term human cortical organoids Open
SARS-CoV2, severe acute respiratory syndrome coronavirus 2, is frequently associated with neurological manifestations. Despite the presence of mild to severe CNS-related symptoms in a cohort of patients, there is no consensus whether the v…
View article: E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development
E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development Open
View article: Ccp1 depletion disrupts network integration of hippocampal parvalbumin interneurons
Ccp1 depletion disrupts network integration of hippocampal parvalbumin interneurons Open
Post-translational modifications (PTMs) of microtubules (MTs) endow them with specific properties that are essential for key cellular functions, such as axonal transport. Polyglutamylation, a PTM that accumulates in long-lived MTs, has bee…
View article: 139 Single-cell proliferation assay enables rapid and quantitative donor screening
139 Single-cell proliferation assay enables rapid and quantitative donor screening Open
View article: Early neuronal inhibition sculpts adult cortical interhemispheric connectivity
Early neuronal inhibition sculpts adult cortical interhemispheric connectivity Open
View article: Loss of Elp3 blocks intestinal tuft cell differentiation via an mTORC1-Atf4 axis
Loss of Elp3 blocks intestinal tuft cell differentiation via an mTORC1-Atf4 axis Open
View article: Significant impact of consumable material and buffer composition for low-cell number proteomic sample preparation
Significant impact of consumable material and buffer composition for low-cell number proteomic sample preparation Open
Proteomics, essential for understanding gene and cell functions, faces challenges with peptide loss due to adsorption onto vial surfaces, especially in samples with low peptide quantities. Using HeLa tryptic digested standard solutions, we…
View article: Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma
Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma Open
View article: SARS-CoV2 infection triggers reactive astrocyte states and inflammatory conditions in long-term Human Cortical Organoids
SARS-CoV2 infection triggers reactive astrocyte states and inflammatory conditions in long-term Human Cortical Organoids Open
SARS-CoV2, severe acute respiratory syndrome coronavirus 2, is frequently associated with neurological manifestations. Despite the presence of mild to severe CNS-related symptoms in a cohort of patients, there is no consensus whether the v…
View article: Significant impact of consumable material and buffer composition for low-cell number proteomic sample preparation
Significant impact of consumable material and buffer composition for low-cell number proteomic sample preparation Open
Proteomics, essential for understanding gene and cell functions, faces challenges with peptide loss due to adsorption onto vial surfaces, especially in samples with low peptide quantities. Using HeLa tryptic digested standard solutions, we…
View article: Author Correction: CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder
Author Correction: CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder Open
View article: Sox9 Inhibits Cochlear Hair Cell Fate by Upregulating Hey1 and HeyL Antagonists of Atoh1
Sox9 Inhibits Cochlear Hair Cell Fate by Upregulating Hey1 and HeyL Antagonists of Atoh1 Open
It is widely accepted that cell fate determination in the cochlea is tightly controlled by different transcription factors (TFs) that remain to be fully defined. Here, we show that Sox9, initially expressed in the entire sensory epithelium…
View article: The dangers of rubella virus
The dangers of rubella virus Open
The rubella virus can interfere with fetal brain development by infecting immune cells called microglia during pregnancy.
View article: Unveiling the Consequences of Adolescent Alcohol Exposure on Prefrontal Cortex Maturation
Unveiling the Consequences of Adolescent Alcohol Exposure on Prefrontal Cortex Maturation Open
View article: Supplementary figures 1-3 from Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma
Supplementary figures 1-3 from Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma Open
Supplementary figures 1-3. Supplementary Figure 1: F14512 structure (A) and effects on Namalwa lymphoma cell line (B-E). Supplementary Figure 2: DNA damage induced by F14512 in Namalwa cells. Supplementary Figure 3: Illustration of decreas…
View article: Data from Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma
Data from Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma Open
Purpose: F14512 is a new topoisomerase II inhibitor containing a spermine moiety that facilitates selective uptake by tumor cells and increases topoisomerase II poisoning. F14512 is currently in a phase I/II clinical trial in patien…
View article: Data from Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma
Data from Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma Open
Purpose: F14512 is a new topoisomerase II inhibitor containing a spermine moiety that facilitates selective uptake by tumor cells and increases topoisomerase II poisoning. F14512 is currently in a phase I/II clinical trial in patien…
View article: Supplementary figures 1-3 from Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma
Supplementary figures 1-3 from Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma Open
Supplementary figures 1-3. Supplementary Figure 1: F14512 structure (A) and effects on Namalwa lymphoma cell line (B-E). Supplementary Figure 2: DNA damage induced by F14512 in Namalwa cells. Supplementary Figure 3: Illustration of decreas…
View article: SMPD4 regulates mitotic nuclear envelope dynamics and its loss causes microcephaly and diabetes
SMPD4 regulates mitotic nuclear envelope dynamics and its loss causes microcephaly and diabetes Open
Biallelic loss-of-function variants in SMPD4 cause a rare and severe neurodevelopmental disorder with progressive congenital microcephaly and early death. SMPD4 encodes a sphingomyelinase that hydrolyses sphingomyelin into ceramide at neut…