Laurent Picot
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View article: Botany, Ethnomedicinal Uses, Biological Activities, Phytochemistry, and Technological Applications of Morinda citrifolia Plants
Botany, Ethnomedicinal Uses, Biological Activities, Phytochemistry, and Technological Applications of Morinda citrifolia Plants Open
Morinda citrifolia L., known as noni, is a tropical plant belonging to the Rubiaceae family and is widely used in traditional medicine for its therapeutic properties. This review compiles botanical, ethnomedicinal, phytochemical, and pharm…
View article: Anticancer Activity of the Marine-Derived Compound Bryostatin 1: Preclinical and Clinical Evaluation
Anticancer Activity of the Marine-Derived Compound Bryostatin 1: Preclinical and Clinical Evaluation Open
Bryostatin 1, a natural macrolide isolated from Bugula neritina, is a potent modulator of protein kinase C (PKC) isoforms with promising anticancer properties. In numerous in vitro studies, bryostatin 1 has been shown to inhibit tumor cell…
View article: New bis-norditerpene by biotransformation of favelines from Cnidoscolus quercifolius using Umbelopsis isabellina as biocatalyst
New bis-norditerpene by biotransformation of favelines from Cnidoscolus quercifolius using Umbelopsis isabellina as biocatalyst Open
Favelines, tricyclic benzylcycloheptene diterpenes predominantly found in Cnidoscolus quercifolius, have demonstrated significant cytotoxic activity against human cancer cell lines, including melanoma. In this study, we employed a combinat…
View article: Single‐Step Isolation of Phyllacanthone From <i>Cnidoscolus quercifolius</i> Using Centrifugal Partition Chromatography
Single‐Step Isolation of Phyllacanthone From <i>Cnidoscolus quercifolius</i> Using Centrifugal Partition Chromatography Open
Favelines, benzocycloheptene diterpenes exclusively found in Cnidoscolus quercifolius , have shown promising anticancer properties, particularly phyllacanthone. Nevertheless, the isolation of these compounds remains challenging due to thei…
View article: Industrial applications of Cannabis sativa (L.): Exploring its biological and nanotechnological potential
Industrial applications of Cannabis sativa (L.): Exploring its biological and nanotechnological potential Open
View article: Polymethoxyflavones from Gardenia oudiepe and semi-synthetic derivatives reduce nociception in mice: Evidence for the involvement of the MAPK pathway
Polymethoxyflavones from Gardenia oudiepe and semi-synthetic derivatives reduce nociception in mice: Evidence for the involvement of the MAPK pathway Open
View article: Exploring the therapeutic potential and chemical properties of trans-chalcone: a comprehensive review
Exploring the therapeutic potential and chemical properties of trans-chalcone: a comprehensive review Open
Aim: Trans-chalcone has emerged as a promising candidate for new therapeutic alternatives, owing to its pharmacological properties and potential in various medical areas. This study aimed to conduct a systematic review of art…
View article: Exploring the Therapeutic Potential of Theobroma cacao L.: Insights from In Vitro, In Vivo, and Nanoparticle Studies on Anti-Inflammatory and Anticancer Effects
Exploring the Therapeutic Potential of Theobroma cacao L.: Insights from In Vitro, In Vivo, and Nanoparticle Studies on Anti-Inflammatory and Anticancer Effects Open
Theobroma cacao L., commonly known as cocoa, has been an integral part of human culture and diet for thousands of years. However, recent scientific research has highlighted its potential therapeutic properties, particularly in the treatmen…
View article: Flavonoids and their derivatives as DNA topoisomerase inhibitors with anti-cancer activity in various cell models: Exploring a novel mode of action
Flavonoids and their derivatives as DNA topoisomerase inhibitors with anti-cancer activity in various cell models: Exploring a novel mode of action Open
View article: Anti-Inflammatory and Anticancer Effects of Anthocyanins in In Vitro and In Vivo Studies
Anti-Inflammatory and Anticancer Effects of Anthocyanins in In Vitro and In Vivo Studies Open
Anthocyanins, a class of flavonoid compounds responsible for the vibrant colors of many fruits and vegetables, have received considerable attention in recent years due to their potential health benefits. This review, focusing on evidence f…
View article: Phototoxicity of the Ethanolic Extract of Skeletonema marinoi for the Dermocosmetic Improvement of Acne
Phototoxicity of the Ethanolic Extract of Skeletonema marinoi for the Dermocosmetic Improvement of Acne Open
Acne is one of the most common dermatological conditions, peaking during adolescence and early adulthood, affecting about 85% of individuals aged 12–24. Although often associated with teenage years, acne can occur at any age, impacting ove…
View article: The Identification of Peptide Inhibitors of the Coronavirus 3CL Protease from a Fucus ceranoides L. Hydroalcoholic Extract Using a Ligand-Fishing Strategy
The Identification of Peptide Inhibitors of the Coronavirus 3CL Protease from a Fucus ceranoides L. Hydroalcoholic Extract Using a Ligand-Fishing Strategy Open
Brown seaweeds of the Fucus genus represent a rich source of natural antiviral products. In this study, a Fucus ceranoides hydroalcoholic extract (FCHE) was found to inhibit 74.2 ± 1.3% of the proteolytic activity of the free SARS-CoV-2 3C…
View article: Deprotonative Metallation of Benzofuran and Benzothiophene Derivatives for the Formation of Tetracyclic and Pentacyclic Heteroaromatic Compounds
Deprotonative Metallation of Benzofuran and Benzothiophene Derivatives for the Formation of Tetracyclic and Pentacyclic Heteroaromatic Compounds Open
N , N ‐dialkylbenzofuran‐ and N , N ‐dialkylbenzothiophene‐2‐carboxamides were readily prepared from bare benzofuran and benzothiophene by deprotocupration followed by trapping with N , N ‐dialkylcarbamoyl chlorides. They were reacted with…
View article: The Precious Potential of the Sacred Tree Chamaecyparis obtusa (Siebold & Zucc.) Endl. as a Source of Secondary Metabolites with Broad Biological Applications
The Precious Potential of the Sacred Tree Chamaecyparis obtusa (Siebold & Zucc.) Endl. as a Source of Secondary Metabolites with Broad Biological Applications Open
Chamaecyparis obtusa (Siebold & Zucc.) Endl., which belongs to the Cupressaceae family, occurs naturally in North America and Asia, especially in Korea, Taiwan and Japan, where it is an evergreen, coniferous, sacred, ethnic tree. It has ma…
View article: In vitro antiherpetic activity of compounds extracted from Sargassum fluitans (Børgesen) Børgesen. Identification and in silico evaluation of potential antiviral molecules in a hydroalcoholic extract
In vitro antiherpetic activity of compounds extracted from Sargassum fluitans (Børgesen) Børgesen. Identification and in silico evaluation of potential antiviral molecules in a hydroalcoholic extract Open
View article: Polymethoxy-/Polyacetyl-Flavones Cytotoxicity Towards Colorectal and Prostate Cancer Cell Lines: Sar, Mechanisms of Action and Evaluation as Potential Adjuvants in Chemotherapy
Polymethoxy-/Polyacetyl-Flavones Cytotoxicity Towards Colorectal and Prostate Cancer Cell Lines: Sar, Mechanisms of Action and Evaluation as Potential Adjuvants in Chemotherapy Open
View article: The antiproliferative activity of Varronia dardani (Taroda) J.S. Mill. roots against human melanoma cells and the isolation of a new hydroanthraquinone
The antiproliferative activity of Varronia dardani (Taroda) J.S. Mill. roots against human melanoma cells and the isolation of a new hydroanthraquinone Open
View article: A Review of Phototoxic Plants, Their Phototoxic Metabolites, and Possible Developments as Photosensitizers
A Review of Phototoxic Plants, Their Phototoxic Metabolites, and Possible Developments as Photosensitizers Open
This study provides a comprehensive overview of the current knowledge regarding phototoxic terrestrial plants and their phototoxic and photosensitizing metabolites. Within the 435,000 land plant species, only around 250 vascular plants hav…
View article: Anti-melanoma potential of inclusion complexes containing phyllacanthone in β-cyclodextrin and sulfobutyl-ether-β-cyclodextrin
Anti-melanoma potential of inclusion complexes containing phyllacanthone in β-cyclodextrin and sulfobutyl-ether-β-cyclodextrin Open
View article: CCDC 2190833: Experimental Crystal Structure Determination
CCDC 2190833: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2190835: Experimental Crystal Structure Determination
CCDC 2190835: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2190837: Experimental Crystal Structure Determination
CCDC 2190837: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2190838: Experimental Crystal Structure Determination
CCDC 2190838: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2190834: Experimental Crystal Structure Determination
CCDC 2190834: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2190836: Experimental Crystal Structure Determination
CCDC 2190836: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2190839: Experimental Crystal Structure Determination
CCDC 2190839: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Biological effect of natural chitosan nanoparticles with transformed roots extract of Leonotis nepetifolia (L.) R.Br. in an in vitro model
Biological effect of natural chitosan nanoparticles with transformed roots extract of Leonotis nepetifolia (L.) R.Br. in an in vitro model Open
View article: Ligand fishing as a tool to screen natural products with anticancer potential
Ligand fishing as a tool to screen natural products with anticancer potential Open
Cancer is the second leading cause of death in the world and its incidence is expected to increase with the aging of the world's population and globalization of risk factors. Natural products and their derivatives have provided a significa…
View article: Anti-Melanoma Potential of Inclusion Complexes Containing Phyllacanthone in β-Cyclodextrin and Sulfobutyl-Ether-β-Cyclodextrin
Anti-Melanoma Potential of Inclusion Complexes Containing Phyllacanthone in β-Cyclodextrin and Sulfobutyl-Ether-β-Cyclodextrin Open
View article: CCDC 2204835: Experimental Crystal Structure Determination
CCDC 2204835: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …