Laurent Pradier
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View article: A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies
A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies Open
Parkinson's disease and multiple system atrophy are members of a class of devastating neurodegenerative diseases called synucleinopathies, which are characterized by the presence of alpha-synuclein (α-Syn) rich aggregates in the brains of …
View article: A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies
A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies Open
Parkinson’s disease and multiple system atrophy are members of a class of devastating neurodegenerative diseases called synucleinopathies, which are characterized by the presence of alpha-synuclein (α-Syn) rich aggregates in the brains of …
View article: Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer’s disease immunotherapeutics
Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer’s disease immunotherapeutics Open
View article: Alzheimer's disease‐associated <scp>R47H TREM2</scp> increases, but wild‐type <scp>TREM2</scp> decreases, microglial phagocytosis of synaptosomes and neuronal loss
Alzheimer's disease‐associated <span>R47H TREM2</span> increases, but wild‐type <span>TREM2</span> decreases, microglial phagocytosis of synaptosomes and neuronal loss Open
Triggering receptor on myeloid cells 2 (TREM2) is an innate immune receptor, upregulated on the surface of microglia associated with amyloid plaques in Alzheimer's disease (AD). Individuals heterozygous for the R47H variant of TREM2 have g…
View article: Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells
Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells Open
The receptor Triggering Receptor Expressed on Myeloid cells 2 (TREM2) is associated with several neurodegenerative diseases including Alzheimer's Disease and TREM2 stimulation represents a novel therapeutic opportunity. TREM2 can be activa…
View article: A calcium-sensitive antibody isolates soluble amyloid-β aggregates and fibrils from Alzheimer’s disease brain
A calcium-sensitive antibody isolates soluble amyloid-β aggregates and fibrils from Alzheimer’s disease brain Open
Aqueously soluble oligomers of amyloid-β peptide may be the principal neurotoxic forms of amyloid-β in Alzheimer’s disease, initiating downstream events that include tau hyperphosphorylation, neuritic/synaptic injury, microgliosis and neur…
View article: Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia
Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia Open
CD33/Sialic acid-binding Ig-like lectin 3 (SIGLEC3) is an innate immune receptor expressed on myeloid cells and mediates inhibitory signaling via tyrosine phosphatases. Variants of CD33 are associated with Alzheimer’s disease (AD) suggesti…
View article: A Novel Selective PKR Inhibitor Restores Cognitive Deficits and Neurodegeneration in Alzheimer Disease Experimental Models
A Novel Selective PKR Inhibitor Restores Cognitive Deficits and Neurodegeneration in Alzheimer Disease Experimental Models Open
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Frontmatter Open
View article: Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model
Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model Open
View article: Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer’s disease
Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer’s disease Open
Antibody therapies for Alzheimer's Disease (AD) hold promise but have been limited by the inability of these proteins to migrate efficiently across the blood brain barrier (BBB). Central nervous system (CNS) gene transfer by vectors like a…
View article: BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation
BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation Open
View article: LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer’s Disease
LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer’s Disease Open
The low-density lipoprotein receptor-related protein-1 (LRP1) has a dual role in the metabolism of the amyloid precursor protein (APP). In cellular models, LRP1 enhances amyloid-β (Aβ) generation via APP internalization and thus its amyloi…
View article: SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA)
SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA) Open
Based on the improved efficacy/safety profile in non-clinical models of SAR228810, a first-in-man single and multiple dose administration clinical study has been initiated in AD patients.
View article: BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr<sup>348</sup> phosphorylation
BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr<sup>348</sup> phosphorylation Open
The bridging integrator 1 gene ( BIN1 ) is a major genetic risk factor for Alzheimer’s disease (AD). In this report, we investigated how BIN1-dependent pathophysiological processes might be associated with Tau. We first generated a cohort …
View article: [P3–038]: ANTI‐AMYLOID ANTIBODIES AS A POTENTIAL THERAPEUTIC FOR ALZHEIMER's DISEASE: NEUROPROTECTIVE ACTIVITY OF SAR228810 AGAINST AMYLOID‐INDUCED NEUROTOXICITY IN VITRO
[P3–038]: ANTI‐AMYLOID ANTIBODIES AS A POTENTIAL THERAPEUTIC FOR ALZHEIMER's DISEASE: NEUROPROTECTIVE ACTIVITY OF SAR228810 AGAINST AMYLOID‐INDUCED NEUROTOXICITY IN VITRO Open
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder which results in impairment of cognitive functions. Neuropathology of AD is characterized by the accumulation of extracellular deposition of beta-amyloid peptide in se…
View article: NF-L in cerebrospinal fluid and serum is a biomarker of neuronal damage in an inducible mouse model of neurodegeneration
NF-L in cerebrospinal fluid and serum is a biomarker of neuronal damage in an inducible mouse model of neurodegeneration Open
View article: SAR110894, a potent histamine H3‐receptor antagonist, displays disease‐modifying activity in a transgenic mouse model of tauopathy
SAR110894, a potent histamine H3‐receptor antagonist, displays disease‐modifying activity in a transgenic mouse model of tauopathy Open
Introduction Tau hyperphosphorylation and neurofibrillary tangles are histopathologic hallmarks of tauopathies. Histamine H3‐receptor antagonists have been proposed to reduce tau hyperphosphorylation in preclinical models. Methods We evalu…
View article: In Vivo Detection of Amyloid Plaques by Gadolinium-Stained MRI Can Be Used to Demonstrate the Efficacy of an Anti-amyloid Immunotherapy
In Vivo Detection of Amyloid Plaques by Gadolinium-Stained MRI Can Be Used to Demonstrate the Efficacy of an Anti-amyloid Immunotherapy Open
Extracellular deposition of β amyloid plaques is an early event associated to Alzheimer's disease. Here, we have used in vivo gadolinium-stained high resolution (29(∗)29(∗)117 μm(3)) magnetic resonance imaging (MRI) to follow-up in a longi…
View article: High-throughput 3D whole-brain quantitative histopathology in rodents
High-throughput 3D whole-brain quantitative histopathology in rodents Open
Histology is the gold standard to unveil microscopic brain structures and pathological alterations in humans and animal models of disease. However, due to tedious manual interventions, quantification of histopathological markers is classic…
View article: Gene Expression Profiling in the APP/PS1KI Mouse Model of Familial Alzheimer’s Disease
Gene Expression Profiling in the APP/PS1KI Mouse Model of Familial Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by early intraneuronal amyloid-β (Aβ) accumulation, extracellular deposition of Aβ peptides, and intracellular hyperphosphorylated tau aggregates. These les…
View article: PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model
PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model Open