Lauretta El Hayek
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View article: Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells
Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells Open
Perturb-seq is a powerful approach to systematically assess how genes and enhancers impact the molecular and cellular pathways of development and disease. However, technical challenges have limited its application in stem-cell-based system…
View article: Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells
Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells Open
Perturb-seq is a powerful approach to systematically assess how genes and enhancers impact the molecular and cellular pathways of development and disease. However, technical challenges have limited its application in stem cell-based system…
View article: Disruption of the autism gene and chromatin regulator KDM5A alters hippocampal cell identity
Disruption of the autism gene and chromatin regulator KDM5A alters hippocampal cell identity Open
Chromatin regulation plays a pivotal role in establishing and maintaining cellular identity and is one of the top pathways disrupted in autism spectrum disorder (ASD). The hippocampus, composed of distinct cell types, is often affected in …
View article: KDM5A mutations identified in autism spectrum disorder using forward genetics
KDM5A mutations identified in autism spectrum disorder using forward genetics Open
Autism spectrum disorder (ASD) is a constellation of neurodevelopmental disorders with high phenotypic and genetic heterogeneity, complicating the discovery of causative genes. Through a forward genetics approach selecting for defective vo…
View article: Author response: KDM5A mutations identified in autism spectrum disorder using forward genetics
Author response: KDM5A mutations identified in autism spectrum disorder using forward genetics Open
View article: Branched-chain amino acids mediate resilience to chronic social defeat stress by activating BDNF/TRKB signaling
Branched-chain amino acids mediate resilience to chronic social defeat stress by activating BDNF/TRKB signaling Open
View article: Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)
Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF) Open
Exercise promotes learning and memory formation. These effects depend on increases in hippocampal BDNF, a growth factor associated with cognitive improvement and the alleviation of depression symptoms. Identifying molecules that are produc…
View article: Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases
Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases Open
View article: Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate
Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate Open
Exercise induces beneficial responses in the brain, which is accompanied by an increase in BDNF, a trophic factor associated with cognitive improvement and the alleviation of depression and anxiety. However, the exact mechanisms whereby ph…
View article: Author response: Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate
Author response: Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Exercise induces beneficial responses in the br…