Lauri Peil
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View article: AbDesign: database of point mutants of antibodies with associated structures reveals poor generalization of binding predictions from machine learning models
AbDesign: database of point mutants of antibodies with associated structures reveals poor generalization of binding predictions from machine learning models Open
Antibodies are naturally evolved molecular recognition scaffolds that can bind a variety of surfaces. Their designability is crucial to the development of biologics, with computational methods holding promise in accelerating the delivery o…
View article: AbDesign: Database of point mutants of antibodies with associated structures reveals poor generalization of binding predictions from machine learning models
AbDesign: Database of point mutants of antibodies with associated structures reveals poor generalization of binding predictions from machine learning models Open
Antibodies are naturally evolved molecular recognition scaffolds that can bind a variety of surfaces. Their designability is crucial to the development of biologics, with computational methods holding promise in accelerating the delivery o…
View article: A conserved phosphorylation mechanism for regulating the interaction between the CMG replicative helicase and its forked DNA substrate
A conserved phosphorylation mechanism for regulating the interaction between the CMG replicative helicase and its forked DNA substrate Open
The CMG helicase is a crucial enzyme complex that plays a vital role in the replication of genomic DNA in eukaryotes. Besides unwinding the DNA template and coordinating the replisome's structure, it is also a key target for signaling path…
View article: Evolving a mitigation of the stress response pathway to change the basic chemistry of life
Evolving a mitigation of the stress response pathway to change the basic chemistry of life Open
Despite billions of years of evolution, there have been only minor changes in the number and types of proteinogenic amino acids and the standard genetic code with codon assignments across the three domains of life. The rigidity of the gene…
View article: Evolving a mitigation of the stress response pathway to change the basic chemistry of life
Evolving a mitigation of the stress response pathway to change the basic chemistry of life Open
Billions of years of evolution have produced only slight variations in the standard genetic code, and the number and identity of proteinogenic amino acids have remained mostly consistent throughout all three domains of life. These observat…
View article: Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control
Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control Open
Ribosome-associated quality control (RQC) pathways monitor and respond to ribosome stalling. Using in vivo UV-crosslinking and mass spectrometry, we identified a C-terminal region in Hel2/Rqt1 as an RNA binding domain. Complementary crossl…
View article: Identification of RNA-associated peptides, iRAP, defines precise sites of protein-RNA interaction
Identification of RNA-associated peptides, iRAP, defines precise sites of protein-RNA interaction Open
The identification of ever-increasing numbers of RNA species has underlined the importance of robust characterization of bona fide sites of protein-RNA interaction. UV crosslinking can be used to identify precise RNA targets for individual…
View article: Protein-RNA linkage and posttranslational modifications of feline calicivirus and murine norovirus VPg proteins
Protein-RNA linkage and posttranslational modifications of feline calicivirus and murine norovirus VPg proteins Open
Members of the Caliciviridae family of positive sense RNA viruses cause a wide range of diseases in both humans and animals. The detailed characterization of the calicivirus life cycle had been hampered due to the lack of robust cell cultu…
View article: Peer Review #2 of "Protein-RNA linkage and posttranslational modifications of feline calicivirus and murine norovirus VPg proteins (v0.1)"
Peer Review #2 of "Protein-RNA linkage and posttranslational modifications of feline calicivirus and murine norovirus VPg proteins (v0.1)" Open
Members of theCaliciviridae family of positive sense RNA viruses cause a wide range of diseases in both humans and animals.The detailed characterization of the calicivirus life cycle had been hampered due to the lack of robust cell culture…
View article: Peer Review #1 of "Protein-RNA linkage and posttranslational modifications of feline calicivirus and murine norovirus VPg proteins (v0.1)"
Peer Review #1 of "Protein-RNA linkage and posttranslational modifications of feline calicivirus and murine norovirus VPg proteins (v0.1)" Open
Members of theCaliciviridae family of positive sense RNA viruses cause a wide range of diseases in both humans and animals.The detailed characterization of the calicivirus life cycle had been hampered due to the lack of robust cell culture…
View article: Protein-RNA linkage and posttranslational modifications of feline calicivirus and murine norovirus VPg proteins
Protein-RNA linkage and posttranslational modifications of feline calicivirus and murine norovirus VPg proteins Open
Members of the Caliciviridae family of positive sense RNA viruses cause a wide range of diseases in both humans and animals. The detailed characterization of the calicivirus life cycle had been hampered due to the lack of robust cell cultu…
View article: Protein-RNA linkage and posttranslational modifications of feline calicivirus and murine norovirus VPg proteins
Protein-RNA linkage and posttranslational modifications of feline calicivirus and murine norovirus VPg proteins Open
Members of the Caliciviridae family of positive sense RNA viruses cause a wide range of diseases in both humans and animals. The detailed characterization of the calicivirus life cycle had been hampered due to the lack of robust cell cultu…
View article: Deciphering the Translation Initiation Factor 5A Modification Pathway in Halophilic Archaea
Deciphering the Translation Initiation Factor 5A Modification Pathway in Halophilic Archaea Open
Translation initiation factor 5A (IF5A) is essential and highly conserved in Eukarya (eIF5A) and Archaea (aIF5A). The activity of IF5A requires hypusine, a posttranslational modification synthesized in Eukarya from the polyamine precursor …
View article: Inside Cover: Chemical Evolution of a Bacterial Proteome (Angew. Chem. Int. Ed. 34/2015)
Inside Cover: Chemical Evolution of a Bacterial Proteome (Angew. Chem. Int. Ed. 34/2015) Open
A first step towards the creation of synthetic cells is described by N. Budisa et al. in their Communication on page 10030 ff. The chemical composition and the genetic code of an auxotrophic E. coli were changed in the frame of a long-term…
View article: Chemical Evolution of a Bacterial Proteome
Chemical Evolution of a Bacterial Proteome Open
We have changed the amino acid set of the genetic code of Escherichia coli by evolving cultures capable of growing on the synthetic noncanonical amino acid L ‐β‐(thieno[3,2‐ b ]pyrrolyl)alanine ([3,2]Tpa) as a sole surrogate for the canoni…