Lauri Soinne
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View article: Burden of Modifiable Risk Factors in Young-Onset Cryptogenic Ischemic Stroke by High-Risk Patent Foramen Ovale
Burden of Modifiable Risk Factors in Young-Onset Cryptogenic Ischemic Stroke by High-Risk Patent Foramen Ovale Open
BACKGROUND: The incidence of young-onset ischemic stroke is rising, driven by cryptogenic ischemic stroke (CIS) and patients without vascular risk factors. This study examines the burden and associations of modifiable traditional, nontradi…
View article: Carotid endarterectomy and the risk of perioperative stroke: The importance of chronic ischaemic lesions and small vessel disease
Carotid endarterectomy and the risk of perioperative stroke: The importance of chronic ischaemic lesions and small vessel disease Open
Background and purpose Perioperative stroke is a well‐recognized complication of carotid endarterectomy (CEA), but well‐performing prediction models do not exist for it. Our aim was to identify novel predictors for perioperative ischaemic …
View article: Long-term cognitive and neurovascular changes after carotid endarterectomy
Long-term cognitive and neurovascular changes after carotid endarterectomy Open
The present findings suggest that CEA may have beneficial long-term effects on cognition. These effects may specifically involve patients with impaired preoperative circulatory adaptive mechanisms.
View article: Retinal vessel diameters and microvascular abnormalities in patients with carotid stenosis before and 6 months after carotid endarterectomy: A prospective study
Retinal vessel diameters and microvascular abnormalities in patients with carotid stenosis before and 6 months after carotid endarterectomy: A prospective study Open
Purpose To assess retinal findings in patients with severe carotid stenosis (CS) before and after carotid endarterectomy (CEA) compared to those in controls. Methods This study is based on 70 patients (male 81%, mean age 69) scheduled for …
View article: Markers of early vascular aging are not associated with cryptogenic ischemic stroke in the young: A case-control study
Markers of early vascular aging are not associated with cryptogenic ischemic stroke in the young: A case-control study Open
Higher CIMT and PWV were associated to higher age, male sex, and several well-documented cardiovascular risk factors. However, in this study we could not prove that either covert atherosclerosis or arterial stiffness contribute to pathogen…
View article: Glutamine synthetase in human carotid plaque macrophages associates with features of plaque vulnerability: An immunohistological study
Glutamine synthetase in human carotid plaque macrophages associates with features of plaque vulnerability: An immunohistological study Open
Our results link connect macrophage GLUL expression with carotid plaque features characterizing plaque vulnerability.
View article: Differential Cognitive Functioning and Benefit From Surgery in Patients Undergoing Coronary Artery Bypass Grafting and Carotid Endarterectomy
Differential Cognitive Functioning and Benefit From Surgery in Patients Undergoing Coronary Artery Bypass Grafting and Carotid Endarterectomy Open
Background Stenosing atherosclerosis in both coronary and carotid arteries can adversely affect cognition. Also their surgical treatments, coronary artery bypass grafting (CABG) and carotid endarterectomy (CEA), are associated with cogniti…
View article: Flicker‐induced retinal vascular dilation in ipsi‐ and contralateral eyes of patients with carotid stenosis before and after carotid endarterectomy: a prospective study
Flicker‐induced retinal vascular dilation in ipsi‐ and contralateral eyes of patients with carotid stenosis before and after carotid endarterectomy: a prospective study Open
Purpose Retinal vascular function was assessed in patients with carotid stenosis (CS) before and six months after carotid endarterectomy (CEA) and in controls at a six‐month interval. Methods We studied 68 patients (81% male, mean age 69) …
View article: Ocular signs of carotid stenosis in ipsi‐ and contralateral eyes before and after carotid endarterectomy: a prospective study
Ocular signs of carotid stenosis in ipsi‐ and contralateral eyes before and after carotid endarterectomy: a prospective study Open
Purpose We describe hypoperfusion‐related and embolic ocular signs of carotid stenosis (CS) before and six months after carotid endarterectomy (CEA) in a CS population. Methods We enrolled prospectively 70 CEA patients (81% male, mean age …
View article: Warfarin Treatment Is Associated to Increased Internal Carotid Artery Calcification
Warfarin Treatment Is Associated to Increased Internal Carotid Artery Calcification Open
Background: Long-term treatment with the vitamin K antagonist warfarin is widely used for the prevention of venous thrombosis and thromboembolism. However, vitamin K antagonists may promote arterial calcification, a phenomenon that has bee…
View article: Endothelial Dysfunction is Associated With Early‐Onset Cryptogenic Ischemic Stroke in Men and With Increasing Age
Endothelial Dysfunction is Associated With Early‐Onset Cryptogenic Ischemic Stroke in Men and With Increasing Age Open
Background The aim of this study was to assess the association between endothelial function and early‐onset cryptogenic ischemic stroke (CIS), with subgroup analyses stratified by sex and age groups. Methods and Results We prospectively en…
View article: Active lifestyle as a reflection of cognitive reserve: The Modified Cognitive Reserve Scale
Active lifestyle as a reflection of cognitive reserve: The Modified Cognitive Reserve Scale Open
Cognitive reserve (CR) refers to individual differences in cognitive processing that can protect from and compensate for functional decline related to ageing or brain pathology. The CR theory postulates that attaining an active and cogniti…
View article: Cognitive Dysfunction and Mortality After Carotid Endarterectomy
Cognitive Dysfunction and Mortality After Carotid Endarterectomy Open
Background: Carotid endarterectomy (CEA) has been associated with both postoperative cognitive dysfunction (POCD) and improvement (POCI). However, the prognostic significance of postoperative cognitive changes related to CEA is largely unk…
View article: Susacin oireyhtymä: silmänpohjan, sisäkorvan ja aivojen pienten valtimoiden tulehdussairaus
Susacin oireyhtymä: silmänpohjan, sisäkorvan ja aivojen pienten valtimoiden tulehdussairaus Open
View article: Subfoveal choroidal thickness in ipsi‐ and contralateral eyes of patients with carotid stenosis before and after carotid endarterectomy: a prospective study
Subfoveal choroidal thickness in ipsi‐ and contralateral eyes of patients with carotid stenosis before and after carotid endarterectomy: a prospective study Open
Purpose To compare subfoveal choroidal thickness (SFCT) and associated clinical variables in patients with carotid stenosis (CS) before and 6 months after carotid endarterectomy (CEA). Methods The prospective non‐randomized Helsinki Caroti…
View article: Postoperative cognitive change after cardiac surgery predicts long‐term cognitive outcome
Postoperative cognitive change after cardiac surgery predicts long‐term cognitive outcome Open
Objectives Postoperative cognitive dysfunction (POCD) is a common consequence of coronary artery bypass grafting. However, domain‐specific associations between postoperative changes and long‐term performance are poorly known. The aim of th…
View article: Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke.
Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke. Open
Background: Results of our recently published phase III randomized clinical trial of ultrasound-enhanced thrombolysis (sonothrombolysis) using an operator-independent, high frequency ultrasound device revealed heterogeneity of patient recr…
View article: The Efficacy of Carotid Surgery by Subgroups: The Concept of Stroke Prevention Potential
The Efficacy of Carotid Surgery by Subgroups: The Concept of Stroke Prevention Potential Open
View article: Magnetic Nanoparticles in Human Cervical Skin
Magnetic Nanoparticles in Human Cervical Skin Open
Magnetic iron oxide nanoparticles, magnetite/maghemite, have been identified in human tissues, including the brain, meninges, heart, liver, and spleen. As these nanoparticles may play a role in the pathogenesis of neurodegenerative disease…
View article: Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial
Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial Open
View article: Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke
Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke Open
Background: Results of our recently published phase III randomized clinical trial of ultrasound-enhanced thrombolysis (sonothrombolysis) using an operator-independent, high frequency ultrasound device revealed heterogeneity of patient recr…
View article: Morphology and histology of silent and symptom-causing atherosclerotic carotid plaques – Rationale and design of the Helsinki Carotid Endarterectomy Study 2 (the HeCES2)
Morphology and histology of silent and symptom-causing atherosclerotic carotid plaques – Rationale and design of the Helsinki Carotid Endarterectomy Study 2 (the HeCES2) Open
Recruitment and carotid endarterectomies of the study patients with carotid atherosclerosis were performed from October 2012 to September 2015. After brain and carotid artery imaging, endarterectomised carotid plaques (CPs) and blood sampl…
View article: Prior Intravenous Stroke Thrombolysis Does Not Increase Complications of Carotid Endarterectomy
Prior Intravenous Stroke Thrombolysis Does Not Increase Complications of Carotid Endarterectomy Open
Background and Purpose— Carotid endarterectomy (CEA) is recommended within 14 days after carotid artery stroke to prevent recurrence. However, the optimal timing of CEA after intravenous thrombolysis (IVT) remains unclear. We studied the s…
View article: Kaulavaltimokirurgian tehokkuuden ja laadun optimointi
Kaulavaltimokirurgian tehokkuuden ja laadun optimointi Open
View article: Response to editorial: Diagnosing carotid near-occlusion with 1-mm side-to-side asymmetry: a tough task made too easy
Response to editorial: Diagnosing carotid near-occlusion with 1-mm side-to-side asymmetry: a tough task made too easy Open
View article: Intracerebral hemorrhage location and outcome among INTERACT2 participants
Intracerebral hemorrhage location and outcome among INTERACT2 participants Open
NCT00716079.
View article: Tunnistatko aivoinfarktin trombektomiakandidaatin
Tunnistatko aivoinfarktin trombektomiakandidaatin Open
View article: Niskakipu (aikuiset). Käypä hoito -suositus. Päivitystiivistelmä
Niskakipu (aikuiset). Käypä hoito -suositus. Päivitystiivistelmä Open
View article: Estimated GFR and the Effect of Intensive Blood Pressure Lowering After Acute Intracerebral Hemorrhage
Estimated GFR and the Effect of Intensive Blood Pressure Lowering After Acute Intracerebral Hemorrhage Open
View article: National Institutes of Health Stroke Scale Item Profiles as Predictor of Patient Outcome
National Institutes of Health Stroke Scale Item Profiles as Predictor of Patient Outcome Open
Background and Purpose— National Institutes of Health Stroke Scale (NIHSS) item profiles that were recently proposed and validated may prove useful for clinical prognostication and research studies. We aimed to validate the NIHSS item prof…