Lauri Vanharanta
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View article: Nuclear envelope-associated lipid droplets are enriched in cholesteryl esters and increase during inflammatory signaling
Nuclear envelope-associated lipid droplets are enriched in cholesteryl esters and increase during inflammatory signaling Open
Cholesteryl esters (CEs) and triacylglycerols (TAGs) are stored in lipid droplets (LDs), but their compartmentalisation is not well understood. Here, we established a hyperspectral stimulated Raman scattering microscopy system to identify …
View article: Adipogenin Dictates Adipose Tissue Expansion by Facilitating the Assembly of a Dodecameric Seipin Complex
Adipogenin Dictates Adipose Tissue Expansion by Facilitating the Assembly of a Dodecameric Seipin Complex Open
Adipogenin (Adig) is an evolutionarily conserved microprotein and is highly expressed in adipose tissues and testis. Here, we identify Adig as a critical regulator for lipid droplet formation in adipocytes. We determine that Adig interacts…
View article: Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols
Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols Open
Cellular cholesterol can be metabolized to its fatty acid esters, cholesteryl esters (CEs), to be stored in lipid droplets (LDs). With triacylglycerols (TGs), CEs represent the main neutral lipids in LDs. However, while TG melts at ~4 °C, …
View article: High‐content imaging and structure‐based predictions reveal functional differences between Niemann‐Pick C1 variants
High‐content imaging and structure‐based predictions reveal functional differences between Niemann‐Pick C1 variants Open
The human Niemann‐Pick C1 (NPC1) gene encoding a 1278 amino acid protein is very heterogeneous. While some variants represent benign polymorphisms, NPC disease carriers and patients may possess rare variants, whose functional importance re…