Laurie J. Hannigan
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View article: Prevalence, Characteristics, and Genetic Architecture of Avoidant/Restrictive Food Intake Phenotypes
Prevalence, Characteristics, and Genetic Architecture of Avoidant/Restrictive Food Intake Phenotypes Open
Importance A narrow range of food consumption and/or restricted eating is a core feature of avoidant/restrictive food intake (ARFI) disorder. However, there is limited knowledge of developmental characteristics of children with ARFI and it…
View article: Identification and validation of postpartum depression subtypes: a population-based cohort study
Identification and validation of postpartum depression subtypes: a population-based cohort study Open
View article: Polygenic and developmental profiles of autism differ by age at diagnosis
Polygenic and developmental profiles of autism differ by age at diagnosis Open
Although autism has historically been conceptualized as a condition that emerges in early childhood 1,2 , many autistic people are diagnosed later in life 3–5 . It is unknown whether earlier- and later-diagnosed autism have different devel…
View article: Genome-wide association study of adolescent-onset depression
Genome-wide association study of adolescent-onset depression Open
Adolescent depression is a heritable psychiatric condition with rising global prevalence and severe long-term outcomes, yet its biological underpinnings remain poorly understood. We conducted the first genome-wide association study of adol…
View article: Transparency in epidemiological analyses of cohort data: A case study of the Norwegian Mother, Father, and Child cohort study (MoBa)
Transparency in epidemiological analyses of cohort data: A case study of the Norwegian Mother, Father, and Child cohort study (MoBa) Open
Epidemiological research is central to our understanding of health and disease. Secondary analysis of cohort data is an important tool in epidemiological research, but is vulnerable to practices that can reduce the validity and robustness …
View article: Meeting the challenges of reproducibility and transparency in analyses of cohort and registry data with open-source software: examples from the PsychGen Centre for Genetic Epidemiology and Mental Health
Meeting the challenges of reproducibility and transparency in analyses of cohort and registry data with open-source software: examples from the PsychGen Centre for Genetic Epidemiology and Mental Health Open
Modern day research -- particularly among the Scandinavian countries -- increasingly relies on data from a combination of large cohort studies and nationwide registry sources. These data are extremely valuable, with vast potential for anal…
View article: Reflections on adapting and promoting transparent and reproducible science practices for researchers engaged in secondary data analyses
Reflections on adapting and promoting transparent and reproducible science practices for researchers engaged in secondary data analyses Open
Researchers motivated to foster a culture valuing reproducibility and transparency in their working environments have, more than ever, a wealth of resources and examples to draw on. Nonetheless, each research context is unique, requiring t…
View article: Unravelling symptom-specific polygenic effects on maternal mental health during the perinatal period and postpartum
Unravelling symptom-specific polygenic effects on maternal mental health during the perinatal period and postpartum Open
Our findings highlight symptom-level associations between PGSs and maternal mental health, which may be obscured when global measures of mental health (e.g., overall scores) are used. Identifying symptom-specific PGS associations could adv…
View article: Age at autism diagnosis in the Norwegian Mother, Father and Child Cohort Study (MoBa): exploring the association with family wellbeing.
Age at autism diagnosis in the Norwegian Mother, Father and Child Cohort Study (MoBa): exploring the association with family wellbeing. Open
For many autistic individuals, close family members represent a crucial source of support throughout their lifetime. Early diagnosis of autism is thought to benefit to both autistic individuals and their family members by facilitating earl…
View article: Self-Injurious Behaviour during Early Childhood in a General Population Sample – Exploratory Analysis in the Norwegian Mother, Father and Child Cohort Study (MoBa)
Self-Injurious Behaviour during Early Childhood in a General Population Sample – Exploratory Analysis in the Norwegian Mother, Father and Child Cohort Study (MoBa) Open
Objective Self-harm is one of the strongest risk factors for suicide and a major public health concern. Most existing research has focused on adolescents and adults. Knowledge about the prevalence and correlates of self-harm in children is…
View article: Youth psychotic experiences: psychometric evaluation and diagnostic associations of the <scp>CAPE</scp> ‐16 in adolescents from the Norwegian Mother, Father and Child Cohort
Youth psychotic experiences: psychometric evaluation and diagnostic associations of the <span>CAPE</span> ‐16 in adolescents from the Norwegian Mother, Father and Child Cohort Open
Background Adolescent self‐reported psychotic experiences are associated with mental illness and could help guide prevention strategies. Youth report substantially more experiences than adults. However, with large societal changes like the…
View article: Genome-wide insights into generalised anxiety using a dimensional symptom severity approach
Genome-wide insights into generalised anxiety using a dimensional symptom severity approach Open
We performed a genome-wide association meta-analysis of generalised anxiety symptom severity in 696,563 individuals of European ancestry from 14 cohorts. We identified 82 independent genome-wide significant variants within 76 loci, 41 of w…
View article: Genome-wide association studies of infant temperament reveal genetic links with later life outcomes
Genome-wide association studies of infant temperament reveal genetic links with later life outcomes Open
We conducted genome-wide association studies on infant temperament – Emotionality, Activity, Shyness and Sociability (N=43,963-72,663) - and meta-analysed the results. We studied the second and third years after birth and a cross-infancy a…
View article: Transparency in epidemiological analyses of cohort data a case study of the Norwegian mother, father, and child cohort study (MoBa)
Transparency in epidemiological analyses of cohort data a case study of the Norwegian mother, father, and child cohort study (MoBa) Open
View article: Intergenerational Transmission of Parental Mental Health and Wellbeing Traits on Offspring Emotional and Behavioural Difficulties
Intergenerational Transmission of Parental Mental Health and Wellbeing Traits on Offspring Emotional and Behavioural Difficulties Open
Importance Parental mental health and wellbeing are strongly associated with offspring emotional, behavioural and temperament difficulties in the preschool years, which in turn are linked to later mental illness. Understanding how intergen…
View article: Co-development of ADHD symptoms and emotional problems from childhood to adulthood: predictors and developmental outcomes
Co-development of ADHD symptoms and emotional problems from childhood to adulthood: predictors and developmental outcomes Open
Objective: Attention-deficit/hyperactivity disorder (ADHD) symptoms and emotional problems frequently co-occur and the magnitude of co-occurrence is known to increase across development. Longitudinal cohort data provides opportunities to u…
View article: Genetic and Epigenetic Foundations of Childhood Internalizing and Externalizing Problems and their Co-occurrence
Genetic and Epigenetic Foundations of Childhood Internalizing and Externalizing Problems and their Co-occurrence Open
Childhood behavioural problems pose long-term mental health risks, yet the biological basis of co-occurring internalizing and externalizing symptoms remains unclear. In a cohort of 40,212 children, we integrated genome-wide association stu…
View article: Avoidant Restrictive Food Intake Phenotypes: Prevalence, Developmental Characteristics, and Genetic Architecture
Avoidant Restrictive Food Intake Phenotypes: Prevalence, Developmental Characteristics, and Genetic Architecture Open
Importance: A narrow range of food consumption and/or restricted eating is a core feature of avoidant restrictive food intake disorder. However, there is limited knowledge of developmental characteristics of children with avoidant/restrict…
View article: Quantifying and adjusting for selection biases in the Norwegian Mother, Father and Child Cohort Study using population-wide individual-level registry information
Quantifying and adjusting for selection biases in the Norwegian Mother, Father and Child Cohort Study using population-wide individual-level registry information Open
Background: Selective participation in research studies hampers researchers’ ability to draw valid and generalizable inferences from analyses. Quantifying and adjusting for selective participation is desirable, but can be challenging given…
View article: Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry Open
Age at onset of walking is an important early childhood milestone which is used clinically and in public health screening. In this genome-wide association study meta-analysis of age at onset of walking ( N = 70,560 European-ancestry infant…
View article: Navigating early risks: Differential outcomes in middle childhood and the compensatory role of kindergarten experiences
Navigating early risks: Differential outcomes in middle childhood and the compensatory role of kindergarten experiences Open
Background It has been proposed that early risk constellations link differentially to later developmental outcomes. However, existing studies often use a limited set of risk indicators, excluding genetic and child‐based risks. It is also u…
View article: Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood
Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood Open
Childhood emotional and behavioural difficulties tend to co-occur and often precede diagnosed neuropsychiatric conditions. Identifying shared and specific risk factors for early-life mental health difficulties is therefore essential for pr…
View article: Investigating relationships between genetic risk, childhood maltreatment and eating disorders
Investigating relationships between genetic risk, childhood maltreatment and eating disorders Open
Importance: The associations between eating disorder polygenic scores and eating disorders areunclear. Furthermore, while both genetic and environmental factors contribute to thedevelopment of eating disorders, their interplay is poorly un…
View article: Direct and indirect genetic effects on early neurodevelopmental traits
Direct and indirect genetic effects on early neurodevelopmental traits Open
Background Neurodevelopmental conditions are highly heritable. Recent studies have shown that genomic heritability estimates can be confounded by genetic effects mediated via the environment (indirect genetic effects). However, the relativ…
View article: Prenatal maternal stress: triangulating evidence for intrauterine exposure effects on birth and early childhood outcomes across multiple approaches
Prenatal maternal stress: triangulating evidence for intrauterine exposure effects on birth and early childhood outcomes across multiple approaches Open
Background Maternal stress during pregnancy may impact offspring development via changes in the intrauterine environment. However, genetic and environmental factors shared between mothers and children might skew our understanding of this p…
View article: The Genetic Architecture of Differentiating Behavioral and Emotional Problems in Early Life
The Genetic Architecture of Differentiating Behavioral and Emotional Problems in Early Life Open
We uncovered genomic signal in the differentiation process, mostly related to common variants associated with neurodevelopmental conditions. Investigating the differentiation of early-life behavioral and emotional problems may enhance our …
View article: Long-term physical health conditions and youth anxiety and depression: Is there a causal link?
Long-term physical health conditions and youth anxiety and depression: Is there a causal link? Open
Background The prevalence of youth anxiety and depression has increased globally, with limited causal explanations. Long-term physical health conditions (LTCs) affect 20–40% of youth, with rates also rising. LTCs are associated with higher…
View article: Intra-familial dynamics of mental distress during the Covid-19 lockdown
Intra-familial dynamics of mental distress during the Covid-19 lockdown Open
Importance Lockdowns and social restrictions imposed in response to the Covid-19 pandemic intensified the proximity and reciprocal exposure among members of nuclear families. It is unclear how variation in mental distress during this perio…
View article: Unravelling symptom-specific polygenic effects on maternal mental health during the perinatal period and postpartum
Unravelling symptom-specific polygenic effects on maternal mental health during the perinatal period and postpartum Open
ImportancePoor maternal mental health can negatively impact affected individuals and families. While genetic factors are important influences on mental health, few studies have used symptom-level analyses to examine how genetic liability i…
View article: Eating Problems Among Adolescent Boys and Girls Before and During the Covid-19 Pandemic
Eating Problems Among Adolescent Boys and Girls Before and During the Covid-19 Pandemic Open
Objective Studies suggest that adolescents reported more eating problems during the pandemic. Using a population-based sample, we compared eating problems—and how they associate with a range of personal characteristics and genetic factors—…