Laurie P. Sutton
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View article: Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2025.3
Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2025.3 Open
Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subuni…
View article: Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement
Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement Open
Opioids trigger structural and functional neural adaptations of the reward circuit that lead to dependence. Synaptic cell adhesion molecules (CAMs) play a pivotal role in circuit organization and present prime candidates for orchestrating …
View article: The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets
The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets Open
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 600…
View article: THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets Open
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasi…
View article: Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2
Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2 Open
Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subuni…
View article: Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders
Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders Open
View article: Striatal RGS7 Regulates Depression-Related Behaviors and Stress-Induced Reinstatement of Cocaine Conditioned Place Preference
Striatal RGS7 Regulates Depression-Related Behaviors and Stress-Induced Reinstatement of Cocaine Conditioned Place Preference Open
The striatum plays a key role in both reward-related and affective behaviors and disruptions to this circuit contributes to depression and drug addiction. However, our understanding of the molecular factors that facilitate and modify these…
View article: Regulators of G protein Signaling (RGS) proteins (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database
Regulators of G protein Signaling (RGS) proteins (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database Open
Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subuni…
View article: Regulators of G protein Signaling (RGS) proteins (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database
Regulators of G protein Signaling (RGS) proteins (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database Open
Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subuni…
View article: NF1-cAMP signaling dissociates cell type–specific contributions of striatal medium spiny neurons to reward valuation and motor control
NF1-cAMP signaling dissociates cell type–specific contributions of striatal medium spiny neurons to reward valuation and motor control Open
The striatum plays a fundamental role in motor learning and reward-related behaviors that are synergistically shaped by populations of D1 dopamine receptor (D1R)- and D2 dopamine receptor (D2R)-expressing medium spiny neurons (MSNs). How v…
View article: Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Open
Regulators of G protein signalling (RGS) proteins display a common RGS domain that interacts with the GTP-bound Gα subunits of heterotrimeric G proteins, enhancing GTP hydrolysis by stabilising the transition state [29, 419, 418], leading …
View article: The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex
The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex Open
View article: Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors
Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors Open
View article: Selective Role of RGS9-2 in Regulating Retrograde Synaptic Signaling of Indirect Pathway Medium Spiny Neurons in Dorsal Striatum
Selective Role of RGS9-2 in Regulating Retrograde Synaptic Signaling of Indirect Pathway Medium Spiny Neurons in Dorsal Striatum Open
In the striatum, medium spiny neurons (MSNs) are heavily involved in controlling movement and reward. MSNs form two distinct populations expressing either dopamine receptor 1 (D1-MSN) or dopamine receptor 2 (D2-MSN), which differ in their …
View article: Orphan receptor GPR158 controls stress-induced depression
Orphan receptor GPR158 controls stress-induced depression Open
Stress can be a motivational force for decisive action and adapting to novel environment; whereas, exposure to chronic stress contributes to the development of depression and anxiety. However, the molecular mechanisms underlying stress-res…
View article: Author response: Orphan receptor GPR158 controls stress-induced depression
Author response: Orphan receptor GPR158 controls stress-induced depression Open
View article: NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum
NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum Open
View article: Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine
Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine Open