Laurie Toullec
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View article: Harnessing <scp>HLA</scp> Divergence for Improved Donor Selection in Haploidentical Haematopoietic Stem Cell Transplantation
Harnessing <span>HLA</span> Divergence for Improved Donor Selection in Haploidentical Haematopoietic Stem Cell Transplantation Open
Haploidentical haematopoietic stem cell transplantation (haplo‐HSCT) with post‐transplant cyclophosphamide (PTCy)‐based graft‐versus‐host disease (GVHD) prophylaxis is commonly used in patients without a fully matched donor. HLA evolutiona…
View article: Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 or 16:02 individuals
Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 or 16:02 individuals Open
BACKGROUNDWeakly virulent environmental mycobacteria (EM) can cause severe disease in HLA-DRB1*15:02 or 16:02 adults harboring neutralizing anti-IFN-γ autoantibodies (nAIGAs). The overall prevalence of nAIGAs in the general population is u…
View article: Macrophage Immune Memory Controls Endometriosis in Mice and Humans
Macrophage Immune Memory Controls Endometriosis in Mice and Humans Open
View article: LINE-1-Mediated AluYa5 Insertion Underlying Complete Autosomal Recessive IFN-γR1 Deficiency
LINE-1-Mediated AluYa5 Insertion Underlying Complete Autosomal Recessive IFN-γR1 Deficiency Open
View article: Role of thyroid dysimmunity and thyroid hormones in endometriosis
Role of thyroid dysimmunity and thyroid hormones in endometriosis Open
Significance Endometriosis is a common gynecological disorder whose physiopathology is still unclear. Thyroid autoimmunity has long been associated with endometriosis, without a mechanistic explanation to link the two pathologies. First, w…
View article: Enterococcus faecium and Ampicillin Susceptibility Determination: Overestimation of Resistance with Disk Diffusion Method Using 2 Micrograms of Ampicillin?
Enterococcus faecium and Ampicillin Susceptibility Determination: Overestimation of Resistance with Disk Diffusion Method Using 2 Micrograms of Ampicillin? Open
We would like to focus your attention on ampicillin susceptibility testing for Enterococcus faecium infections. Ampicillin resistance in E. faecium is due to two distinct mechanisms: low-level resistance based on increased quantity of peni…
View article: Predictive Modeling of Tacrolimus Dose Requirement Based on High-Throughput Genetic Screening
Predictive Modeling of Tacrolimus Dose Requirement Based on High-Throughput Genetic Screening Open
Any biochemical reaction underlying drug metabolism depends on individual gene-drug interactions and on groups of genes interacting together. Based on a high-throughput genetic approach, we sought to identify a set of covariant single-nucl…