Explanipedia

The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway Open

Jeffrey M. Hollomon, Zhongle Liu, Scott Rusin, Nicole P. Jenkins, Allia K. Smith , et al. · 2022

Ssn3, also known as Cdk8, is a member of the four protein Cdk8 submodule within the multi-subunit Mediator complex involved in the co-regulation of transcription. In Candida albicans , the loss of Ssn3 kinase activity affects multiple phen…

The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway Open

Jeffrey M. Hollomon, Zhongle Liu, Scott Rusin, Nicole P. Jenkins, Allia K. Smith , et al. · 2021

Ssn3, also known as Cdk8, is a member of the four protein Cdk8 submodule within the multi-subunit Mediator complex involved in the co-regulation of transcription. In Candida albicans , the loss of Ssn3 kinase activity affects multiple phen…

Candida albicans Zn Cluster Transcription Factors Tac1 and Znc1 Are Activated by Farnesol To Upregulate a Transcriptional Program Including the Multidrug Efflux Pump CDR1 Open

Zhongle Liu, John M. Rossi, Lawrence C. Myers · 2018

Farnesol, a quorum-sensing molecule, inhibits Candida albicans hyphal formation, affects its biofilm formation and dispersal, and impacts its stress response. Several aspects of farnesol's mechanism of action remain incompletely uncharacte…

C. albicans Zn Cluster Transcription Factors Tac1 and Znc1 are Activated by Farnesol to Up Regulate a Transcriptional Program Including the Multi-Drug Efflux Pump CDR1 Open

Zhongle Liu, John M. Rossi, Lawrence C. Myers · 2018

Farnesol, a quorum-sensing molecule, inhibits C. albicans hyphal formation, affects its biofilm formation and dispersal, and impacts its stress response. Several aspects of farnesol’s mechanism of action remain incompletely uncharacterized…

Mediator Tail Module Is Required for Tac1-Activated CDR1 Expression and Azole Resistance in Candida albicans Open

Zhongle Liu, Lawrence C. Myers · 2017

The human fungal pathogen Candida albicans develops drug resistance after long-term exposure to azole drugs in the treatment of chronic candidiasis. Gain-of-function (GOF) mutations in the transcription factor Tac1 and the consequent expre…

Candida albicans Swi/Snf and Mediator Complexes Differentially Regulate Mrr1-Induced MDR1 Expression and Fluconazole Resistance Open

Zhongle Liu, Lawrence C. Myers · 2017

Long-term azole treatment of patients with chronic Candida albicans infections can lead to drug resistance. Gain-of-function (GOF) mutations in the transcription factor Mrr1 and the consequent transcriptional activation of MDR1 , a drug ef…

Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp. Open

Zhongle Liu, Gary P. Moran, Derek J. Sullivan, Donna M. MacCallum, Lawrence C. Myers · 2016

Filamentous growth is a hallmark of C. albicans pathogenicity compared to less-virulent ascomycetes. A multitude of transcription factors regulate filamentous growth in response to specific environmental cues. Our work, however, suggests t…

Analysis of the Candida albicans Phosphoproteome Open

Sven D. Willger, Z. Liu, R. A. Olarte, Mark E. Adamo, Jason Stajich , et al. · 2015

Candida albicans is an important human fungal pathogen in both immunocompetent and immunocompromised individuals. C. albicans regulation has been studied in many contexts, including morphological transitions, mating competence, biofilm for…

Telomeric ORFS in Candida albicans: Does Mediator Tail Wag the Yeast? Open

Derek J. Sullivan, Judith Berman, Lawrence C. Myers, Gary P. Moran · 2015

Recent studies of fungal genomes have shown that subtelomeric regions of chromosomes are areas of rapid evolution that facilitate adaptation to novel niches [1]. Several years ago, analysis of the genome of the human pathogenic yeast Candi…

Fungal Mediator Tail Subunits Contain Classical Transcriptional Activation Domains Open

Zhongle Liu, Lawrence C. Myers · 2015

Classical activation domains within DNA-bound eukaryotic transcription factors make weak interactions with coactivator complexes, such as Mediator, to stimulate transcription. How these interactions stimulate transcription, however, is unk…

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