Lawrence Chukwudi Nwabudike
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View article: Special Issue “Diagnosis and Management of Skin Diseases, Related Disorders and Their Comorbidities”
Special Issue “Diagnosis and Management of Skin Diseases, Related Disorders and Their Comorbidities” Open
Dermatology is a continuously evolving specialty and touches on every part of the field of medicine [...]
View article: A Journey Along the Boulevard of Bioactive Compounds from Natural Sources, with Cosmetic and Pharmaceutical Potential: Bee Venom, Cobra Venom, Ficus carica
A Journey Along the Boulevard of Bioactive Compounds from Natural Sources, with Cosmetic and Pharmaceutical Potential: Bee Venom, Cobra Venom, Ficus carica Open
Animal venom and plant extracts have been used since ancient times in traditional medicine worldwide. Natural components, valued for their safety and effectiveness, have been consistently used in cosmetic and pharmaceutical applications. W…
View article: Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity
Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity Open
In this study, we focused on innovative approaches to improve drug administration in oral pathology, especially by transmucosal and transdermal pathways. These improvements refer to the type of microneedles used (proposing needles in the s…
View article: Natural Sources of Therapeutic Agents Used in Skin Conditions
Natural Sources of Therapeutic Agents Used in Skin Conditions Open
Skin conditions are numerous and often have a major impact on patients’ quality of life, and effective and safe treatment is very important. The conventional drugs used for skin diseases are usually corticosteroids and antimicrobial produc…
View article: Case report: Abrikossoff's tumor of the facial skin
Case report: Abrikossoff's tumor of the facial skin Open
Abrikossoff tumors, also known as granular cell tumors (GCT), originate from Schwann cells. The most common location is in the oral cavity, followed by the skin, but they can also be found in the breast, digestive tract, tracheobronchial t…
View article: Strategies for Improving Transdermal Administration: New Approaches to Controlled Drug Release
Strategies for Improving Transdermal Administration: New Approaches to Controlled Drug Release Open
In this work, we aim to address several strategies to improve transdermal drug delivery, such as iontophoresis, sonophoresis, electroporation and micron. We also propose a review of some transdermal patches and their applications in medici…
View article: Clinical, Dermoscopic and Microscopic Features of a “Collision Tumour” Ultimately Confirmed as a Regressing Melanoma – Lessons Learnt from a Chance Diagnosis
Clinical, Dermoscopic and Microscopic Features of a “Collision Tumour” Ultimately Confirmed as a Regressing Melanoma – Lessons Learnt from a Chance Diagnosis Open
Spontaneous regression of malignant melanoma was first reported over a century ago. Clinically, areas of blue or grey colouration in lesions may be indicative of regression. Dermoscopy is a very useful tool for diagnosing regression. An im…
View article: An integrative therapeutic approach to elephantiasis nostras verrucosa: A case report
An integrative therapeutic approach to elephantiasis nostras verrucosa: A case report Open
Elephantiasis nostras is a chronic disorder that is difficult to treat. It is characterized by marked lymphedema, associated with hyperkeratosis, ulceration, deep skin folds and a cobblestone appearance of the skin. Causes include parasiti…
View article: Orthopaedic manifestations of neurofibromatosis type 1: A case report
Orthopaedic manifestations of neurofibromatosis type 1: A case report Open
Neurofibromatosis type 1 (NF1) or von Recklinghausen disease is one of the most common autosomal dominant genetic diseases. It is characterized by 'café-au-lait' spots and multiple tumors starting from the central and peripheric nervous sy…
View article: Therapy Delayed is Therapy Denied: A Case Report of Melanoma Misdiagnosed as Diabetic Foot Ulcer
Therapy Delayed is Therapy Denied: A Case Report of Melanoma Misdiagnosed as Diabetic Foot Ulcer Open
Malignant melanoma is a deadly form of skin cancer, and prompt diagnosis is a key factor in providing adequate, life-saving therapy. A 75-year-old man, with long-standing type 2 diabetes mellitus, presented with a 2- to 3-year history of r…
View article: Nevi, biologics for psoriasis and the risk for skin cancer: A real concern? (Case presentation and short review)
Nevi, biologics for psoriasis and the risk for skin cancer: A real concern? (Case presentation and short review) Open
Psoriasis is a systemic inflammatory cutaneous disease that affects approximately 2% of the world's population. Systemic treatments and biologic treatment therapies are a powerful option for patients with moderate to severe psoriasis. Some…
View article: Nail changes in diabetes
Nail changes in diabetes Open
Diabetes is a common condition that is increasing in incidence worldwide. Although the skin manifestations of this condition are well described, there is scant literature on the associated nail changes. In this review, we describe the vari…
View article: A Working Hypothesis on Vesicular Lesions Related to COVID-19 Infection, Koebner Phenomena Type V, and a Short Review of Related Data
A Working Hypothesis on Vesicular Lesions Related to COVID-19 Infection, Koebner Phenomena Type V, and a Short Review of Related Data Open
SARS-CoV-2 has recently been associated with the reactivation of varicella zoster virus in patients. This is potentially an observation of a local susceptibility of the skin in areas of vesicle formation. This article explores the dermatol…
View article: Chitin‐lipid interactions and the potential relationship between Demodex and <scp>SARS‐CoV</scp> ‐2
Chitin‐lipid interactions and the potential relationship between Demodex and <span>SARS‐CoV</span> ‐2 Open
Already from the early days of the COVID-19 pandemic, regulatory agencies have attempted to ascertain the possible routes of SARS-CoV-2 viral transmission. It is hypothesized that the lipid bilayer that surrounds the SARS-CoV-2 improves it…
View article: Multifactorial expression of IL‑6 with update on COVID‑19 and the therapeutic strategies of its blockade (Review)
Multifactorial expression of IL‑6 with update on COVID‑19 and the therapeutic strategies of its blockade (Review) Open
Interleukin 6 (IL-6), a cytokine produced by various cells of the human body (macrophages, lymphocytes, astrocytes, ischemic myocytes, endothelial cells) has both pro-inflammatory and anti-inflammatory properties, being a key component in …
View article: New data about sexually transmitted <scp>COVID‐19</scp>
New data about sexually transmitted <span>COVID‐19</span> Open
Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.
View article: Spectral forecast: A general purpose prediction model as an alternative to classical neural networks
Spectral forecast: A general purpose prediction model as an alternative to classical neural networks Open
Here, we describe a general-purpose prediction model. Our approach requires three matrices of equal size and uses two equations to determine the behavior against two possible outcomes. We use an example based on photon-pixel coupling data …
View article: Undesirable Effects of Some Topical Antiseptics Chemical, pharmacological and dermatological aspects
Undesirable Effects of Some Topical Antiseptics Chemical, pharmacological and dermatological aspects Open
Topical antiseptics are a diverse group of agents that are widely used in medicine for the antimicrobial properties. Despite their long history and broad application, caution must be exercised in their use, especially in the pediatric age …
View article: Case series of an alternative therapy for generalised lichen planus: Four case studies
Case series of an alternative therapy for generalised lichen planus: Four case studies Open
Lichen planus (LP) is an idiopathic, cell-mediated immune disorder, accompanied by itching. Spontaneous remission occurs. Topical and systemic therapies are utilised. Four cases of generalized LP with and without mucosal involvement treate…
View article: Immunologic adverse reactions of β-blockers and the skin (Review)
Immunologic adverse reactions of β-blockers and the skin (Review) Open
β-Blockers are a widely utilised class of medication. They have been in use for a variety of systemic disorders including hypertension, heart failure and intention tremors. Their use in dermatology has garnered growing interest with the di…
View article: Statins. A Review on Structural Perspectives, Adverse Reactions and Relations with Non-melanoma Skin Cancer
Statins. A Review on Structural Perspectives, Adverse Reactions and Relations with Non-melanoma Skin Cancer Open
The present paper aims to review an important class of medicine widely used in the therapy of hypercholesterolemia, namely statins. We have presented the main adverse reactions and the relation between statins and non-melanoma skin cancer,…
View article: Hydrochlorothiazide: Chemical Structure, Therapeutic, Phototoxic and Carcinogenetic Effects in Dermatology
Hydrochlorothiazide: Chemical Structure, Therapeutic, Phototoxic and Carcinogenetic Effects in Dermatology Open
The present paper is a review on hydrochlorothiazide, a diuretic frequently used in therapeutics, also underlining several particularities observed in time and correlated with the results in the literature in what concerns the phototoxic a…
View article: Supplementary Material for: Case Reports of Acne and Homeopathy
Supplementary Material for: Case Reports of Acne and Homeopathy Open
Background: Acne vulgaris is a self-limiting disorder of the pilosebaceous unit. The aesthetic aspect of the disorder may provoke depression and diminish the quality of life. A number of agents are used for acne treatment, e.g., retinoids,…