Explanipedia

The Science of Precision Prevention Open

Thomas A. Pearson, Debbie Vitalis, Charlotte Pratt, Rebecca Campo, Antonis A. Armoundas , et al. · 2023

Precision prevention embraces personalized prevention but includes broader factors such as social determinants of health to improve cardiovascular health. The quality, quantity, precision, and diversity of data relatable to individuals and…

Earlier treatment in adults with high lifetime risk of cardiovascular diseases: What prevention trials are feasible and could change clinical practice? Report of a National Heart, Lung, and Blood Institute (NHLBI) Workshop Open

Ann Marie Návar, Lawrence J. Fine, Walter T. Ambrosius, Arleen F. Brown, Pamela S. Douglas , et al. · 2022

The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Serv…

Implementing the National Heart, Lung, and Blood Institute’s Strategic Vision in the Division of Cardiovascular Sciences—2022 Update Open

Meagan G. Grant, Charlotte Pratt, Renee Wong, Ebyan Addou, Patrice Desvigne‐Nickens , et al. · 2022

Spurred by the 2016 release of the National Heart, Lung, and Blood Institute’s Strategic Vision, the Division of Cardiovascular Sciences developed its Strategic Vision Implementation Plan—a blueprint for reigniting the decline in cardiovas…

Proceedings From a National Heart, Lung, and Blood Institute and the Centers for Disease Control and Prevention Workshop to Control Hypertension Open

Yvonne Commodore‐Mensah, Fleetwood Loustalot, Cheryl Dennison Himmelfarb, Patrice Desvigne‐Nickens, Vandana Sachdev , et al. · 2021

Hypertension treatment and control prevent more cardiovascular events than management of other modifiable risk factors. Although the age-adjusted proportion of US adults with controlled blood pressure (BP) defined as <140/90 mm Hg, impr…

SPRINT Revisited: Updated Results and Implications Open

Jackson T. Wright, Paul K. Whelton, Karen Johnson, Joni K. Snyder, David M. Reboussin , et al. · 2021

The SPRINT (Systolic Blood Pressure Intervention Trial) results have influenced clinical practice but have also generated discussion regarding the validity, generalizability, and importance of the findings. Following the SPRINT primary res…

Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure Open

Manjula Kurella Tamura, Sarah A. Gaussoin, Nicholas M. Pajewski, Greg Zaharchuk, Barry I. Freedman , et al. · 2021

Final Report of a Trial of Intensive versus Standard Blood-Pressure Control Open

Cora E. Lewis, Lawrence J. Fine, Srinivasan Beddhu, Alfred K. Cheung, William C. Cushman , et al. · 2021

Among patients who were at increased cardiovascular risk, targeting a systolic blood pressure of less than 120 mm Hg resulted in lower rates of major adverse cardiovascular events and lower all-cause mortality than targeting a systolic blo…

Association of Intensive vs Standard Blood Pressure Control With Magnetic Resonance Imaging Biomarkers of Alzheimer Disease Open

Ilya M. Nasrallah, Sarah A. Gaussoin, Raymond Pomponio, Sudipto Dolui, Güray Erus , et al. · 2021

ClinicalTrials.gov Identifier: NCT01206062.

Cardiopulmonary Impact of Particulate Air Pollution in High-Risk Populations Open

Jonathan Newman, Deepak L. Bhatt, Sanjay Rajagopalan, John R. Balmes, Michael Bräuer , et al. · 2020

Effects of intensive versus standard blood pressure control on domain-specific cognitive function: a substudy of the SPRINT randomised controlled trial Open

Stephen R. Rapp, Sarah A. Gaussoin, Bonnie C. Sachs, Gordon J. Chelune, Mark A. Supiano , et al. · 2020

Trends in Blood Pressure Control Among US Adults With Hypertension, 1999-2000 to 2017-2018 Open

Paul Muntner, Shakia T. Hardy, Lawrence J. Fine, Byron C. Jaeger, Gregory Wozniak , et al. · 2020

In a series of cross-sectional surveys weighted to be representative of the adult US population, the prevalence of controlled BP increased between 1999-2000 and 2007-2008, did not significantly change from 2007-2008 through 2013-2014, and …

Effect of Intensive Blood Pressure Lowering on the Risk of Atrial Fibrillation Open

Elsayed Z. Soliman, Fazlur Rahman, Zhu-Ming Zhang, Carlos J. Rodríguez, Tara I. Chang , et al. · 2020

It remains uncertain whether intensive control of blood pressure (BP) results in a lower risk of atrial fibrillation (AF) in patients with hypertension. Using data from SPRINT (Systolic Blood Pressure Intervention Trial), which enrolled pa…

Incidence of statin use in older adults with and without cardiovascular disease and diabetes mellitus, January 2008- March 2018 Open

Catherine A. Panozzo, Lesley H. Curtis, James Marshall, Lawrence J. Fine, Barbara L. Wells , et al. · 2019

Incidence of statin use varied by CVD and DM comorbidity, and was lowest among those without CVD. These results highlight the potential clinical equipoise to conduct large pragmatic clinical trials to generate evidence that could be used t…

Implementing the National Heart, Lung, and Blood Institute’s Strategic Vision in the Division of Cardiovascular Sciences Open

David C. Goff, Denis B. Buxton, Gail D. Pearson, Gina S. Wei, Teri E. Gosselin , et al. · 2019

As we commemorate the 70th anniversary of the National Heart, Lung, and Blood Institute and celebrate important milestones that have been achieved by the division of cardiovascular sciences, it is imperative that division of cardiovascular…

Effects of Intensive Systolic Blood Pressure Lowering on Cardiovascular Events and Mortality in Patients With Type 2 Diabetes Mellitus on Standard Glycemic Control and in Those Without Diabetes Mellitus: Reconciling Results From ACCORD BP and SPRINT Open

Srinivasan Beddhu, Glenn M. Chertow, Tom Greene, Paul K. Whelton, Walter T. Ambrosius , et al. · 2018

Background Intensive systolic blood pressure ( SBP ) lowering significantly reduced cardiovascular disease ( CVD ) events in SPRINT (Systolic Blood Pressure Intervention Trial) but not in ACCORD BP (Action to Control Cardiovascular Risk in…

A new modeling and inference approach for the Systolic Blood Pressure Intervention Trial outcomes Open

Song Yang, Walter T. Ambrosius, Lawrence J. Fine, Adam P. Bress, William C. Cushman , et al. · 2018

Background/aims In clinical trials with time-to-event outcomes, usually the significance tests and confidence intervals are based on a proportional hazards model. Thus, the temporal pattern of the treatment effect is not directly considere…

Syncope, Hypotension, and Falls in the Treatment of Hypertension: Results from the Randomized Clinical Systolic Blood Pressure Intervention Trial Open

Kaycee M. Sink, Gregory W. Evans, Ronald I. Shorr, Jeffrey T. Bates, Dan R. Berlowitz , et al. · 2018

Objective To determine predictors of serious adverse events ( SAE s) involving syncope, hypotension, and falls, with particular attention to age, in the Systolic Blood Pressure Intervention Trial. Design Randomized clinical trial. Setting …

Blood Pressure Measurement in SPRINT (Systolic Blood Pressure Intervention Trial) Open

Karen Johnson, Paul K. Whelton, William C. Cushman, Jeffrey A. Cutler, Gregory W. Evans , et al. · 2018

Recent publications have stated that the blood pressure (BP) measurement technique used in SPRINT (Systolic Blood Pressure Intervention Trial) was unattended. However, the SPRINT protocol does not address the issue of attendance. A survey …

Effect of Intensive Blood Pressure Lowering on Left Ventricular Hypertrophy in Patients With Hypertension Open

Elsayed Z. Soliman, Walter T. Ambrosius, William C. Cushman, Zhu-Ming Zhang, Jeffrey T. Bates , et al. · 2017

Background: It is currently unknown whether intensive blood pressure (BP) lowering beyond that recommended would lead to more lowering of the risk of left ventricular hypertrophy (LVH) in patients with hypertension and whether reducing the…

Effect of Intensive Blood Pressure Treatment on Heart Failure Events in the Systolic Blood Pressure Reduction Intervention Trial Open

Bharathi Upadhya, Michael V. Rocco, Cora E. Lewis, Suzanne Oparil, Laura Lovato , et al. · 2017

Background— Acute decompensated heart failure (ADHF) was a frequent common outcome in SPRINT (Systolic Blood Pressure Intervention Trial). We examined whether there was differential reduction in ADHF events from intensive blood pressure [B…

Decline in Cardiovascular Mortality Open

George A. Mensah, Gina S. Wei, Paul D. Sorlie, Lawrence J. Fine, Yves Rosenberg , et al. · 2017

If the control of infectious diseases was the public health success story of the first half of the 20th century, then the decline in mortality from coronary heart disease and stroke has been the success story of the century’s past 4 decade…

Building on a Legacy of Hypertension Research Open

George A. Mensah, Zorina S. Galis, Lawrence J. Fine, Melissa E. Garcia, Daniel Levy , et al. · 2016

Effect of Intensive Versus Standard Clinic-Based Hypertension Management on Ambulatory Blood Pressure Open

Paul E. Drawz, Nicholas M. Pajewski, Jeffrey T. Bates, Natalie A. Bello, William C. Cushman , et al. · 2016

The effect of clinic-based intensive hypertension treatment on ambulatory blood pressure (BP) is unknown. The goal of the SPRINT (Systolic Blood Pressure Intervention Trial) ambulatory BP ancillary study was to evaluate the effect of inten…

SPRINT and Implications for Target Organ Protection in African Americans Open

Jackson T. Wright, Lawrence J. Fine · 2016

Ethn Dis. 2016;26(3):271-274; doi:10.18865/ed.26.3.271

The Productivity of NHLBI‐Funded Obesity Research, 1983‐2013 Open

Holly L. Nicastro, Chris Belter, Michael S. Lauer, Sean A. Coady, Lawrence J. Fine , et al. · 2016

Objective To describe and elucidate the time trends of the academic productivity of NHLBI's obesity‐related research funding via bibliometric analysis of 30 years of NHLBI‐supported obesity‐related publications. Methods In total, 3,545 NHL…

Chronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults Open

Manjula Kurella Tamura, Nicholas M. Pajewski, R. Nick Bryan, Daniel E. Weiner, Matthew Diamond , et al. · 2016

Among nondiabetic hypertensive adults, reduced eGFR was associated with higher CBF and higher UACR was associated with larger abnormal WMV.

Rebbe Nachman of Bratslav's Teachings on Melancholy and Joy Open

Lawrence J. Fine · 2016

The several texts presented here are from the teachings of Rebbe Nachman of Bratslav (1772-1810), great-grandson of the Ba’al Shem Tov, and one of the very most significant figures in the history of early Hasidism. They are from part two (…

SPRINT Trial Results Open

William C. Cushman, Paul K. Whelton, Lawrence J. Fine, Jackson T. Wright, David M. Reboussin , et al. · 2015

News from NIH: a center for translation research and implementation science Open

George A. Mensah, Michael M. Engelgau, Catherine M. Stoney, Helena Mishoe, Peter Kaufmann , et al. · 2015

Journal Article News from NIH: a center for translation research and implementation science Get access For the Trans-NHLBI T4 Translation Research Work Groups For the Trans-NHLBI T4 Translation Research Work Groups Search for other works b…

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